Antioxidant, antilipidemic and antidiabetic effects of ficusin with their effects on GLUT4 translocation and PPARγ expression in type 2 diabetic rats

Irudayaraj, Santiagu Stephen; Stalin, Antony; Sunil, Christudas; Duraipandiyan, Veeramuthu; Al-Dhabi, Naïf Abdullah; Ignacimuthu, S.

doi:10.1016/j.cbi.2016.06.023

Cited by 49 publications

(37 citation statements)

References 37 publications

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“…In addition, chronic dyslipidemia causes lipid deposition and induces pancreatic lipotoxicity, thus impairing insulin secretion and promoting the progression of type 2 diabetes (Litwak et al 2015). In this study, both of plasma TC and TG levels were significantly increased in type 2 diabetic rats (Figure 2), which were agreed with the previous report (Irudayaraj et al 2016). And ZDQ treatment remarkably lowered TG, and to a certain extent decreased TC.…”

Section: Zdq Reduced Plasma Tc and Tg In Type 2 Diabetic Ratssupporting

confidence: 93%

Anti-Diabetic Effects of Zhuoduqing Formula, a Chinese Herbal Decoction, on a Rat Model of Type 2 Diabetes

Feng¹,

Tang²,

Jiang³

et al. 2017

Afr J Tradit Complement Altern Med

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Section: Zdq Reduced Plasma Tc and Tg In Type 2 Diabetic Ratssupporting

confidence: 93%

Anti-Diabetic Effects of Zhuoduqing Formula, a Chinese Herbal Decoction, on a Rat Model of Type 2 Diabetes

Feng¹,

Tang²,

Jiang³

et al. 2017

Afr J Tradit Complement Altern Med

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“…Zhang et al [36] conclude that the antihyperglycemic activity of FC may be due to the antioxidant effect of its phytochemicals. Certain antioxidants in FC that may contribute to its antihyperglycemic effect are quercetin [2,37,38], kaempferol [37,39], ficusin [40], ferulic acid [2], and caffeoylmalic acid [39]. It is found that quercetin delays oxidant injury and cell death due to the oxidation by free radicals [37], improves insulin signaling and sensitivity [41], as well as increases glucose uptake by cell [42].…”

Section: Antihyperglycemic Activity Of Fc Extractmentioning

confidence: 99%

“…Kaempferol inhibits the breakdown of polysaccharides to glucose by α-glucosidase, as it is a carbohydrate digesting enzyme [43], and activates AMPK to mediate an antidiabetic effect by inhibiting hepatic glucose production [30]. Ficusin restores insulin level in diabetic rats due to regularized β-cell, and improves glucose utilization by increasing the expression level of glucose transporter protein (GLUT) [40]. Next, ferulic acid inhibits gluconeogenesis via the decrease of enzyme of gluconeogenesis, which are phosphoenolpyruvate carboxinase (PEPCK) and glucose-6-phosphatase [44].…”

Section: Antihyperglycemic Activity Of Fc Extractmentioning

confidence: 99%

Sperm Proteomics Analysis of Diabetic Induced Male Rats as Influenced by Ficus carica Leaf Extract

et al. 2020

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Diabetes mellitus is shown to bring negative effects on male reproductive health due to long-term effects of insulin deficiency or resistance and increased oxidative stress. Ficus carica (FC), an herbal plant, known to have high antioxidant activity and antidiabetic properties, has been used traditionally to treat diabetes. The objective of this study is to determine the potential of the FC leaf extract in improving sperm quality of streptozotocin (STZ) induced diabetic male rats from proteomics perspective. A total of 20 male rats were divided into four groups; normal (nondiabetic rats), negative control (diabetic rats without treatment), positive control (diabetic rats treated with 300 mg/kg metformin), and FC group (diabetic rats treated with 400 mg/kg FC extract). The treatments were given via oral gavage for 21 consecutive days. The fasting blood glucose (FBG) level of FC treated group demonstrated a significant (p < 0.05) decrease compared to negative group after 21 days of treatment, as well as a significant (p < 0.05) increase in the sperm quality parameters compared to negative group. Sperm proteomics analysis on FC treated group also exhibited the increase of total protein expression especially the proteins related to fertility compared to negative group. In conclusion, this study clearly justified that FC extract has good potential as antihyperglycemic and profertility agent that may be beneficial for male diabetic patients who have fertility problems.

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“…Previous studies have demonstrated that PPAR-γ and GLUT4 protein expression levels were downregulated at the time of diabetes (19). Additionally, upregulated PPAR-γ and GLUT4 protein expression levels are associated with protective effects against DN (20).…”

Section: Discussionmentioning

confidence: 92%

“…Additionally, upregulated PPAR-γ and GLUT4 protein expression levels are associated with protective effects against DN (20). GLUT4 is a transmembrane transport protein that promotes glucose transport to insulin-sensitive tissues for intracellular utilization (19). In this way, it can maintain normal physiological function of cells.…”

Section: Discussionmentioning

confidence: 99%

Trigonelline reduced diabetic nephropathy and insulin resistance in type�2 diabetic rats through peroxisome proliferator‑activated receptor‑γ

Wang

et al. 2019

Exp Ther Med

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Trigonelline has been reported to serve an important role in cell cycle control, oxidative and ultraviolet stress and DNA methylation. In the present study, the effects of trigonelline were examined on type-2 diabetes mellitus (T2DM)-induced renal dysfunction, and its possible mechanism was investigated. Sprague-Dawley rats were fed with high-fat diet (HFD) for 4 weeks and intraperitoneally injected with 35 mg/kg of streptozotocin for 4 weeks. As a result, trigonelline increased body weight, inhibited the kidney weight/body weight ratio and blood glucose levels, and reduced the levels of blood urea nitrogen, creatinine and albumin in type 2 diabetic rats. In addition, trigonelline also reduced inflammation, oxidative stress and kidney cell apoptosis in T2DM rats. In terms of the molecular mechanisms involved, trigonelline induced the protein expression of peroxisome proliferator-activated receptor (PPAR)-γ and suppressed glucose transporter 4 but suppressed the protein expression of tumor necrosis factor-α and leptin in T2DM rats. The present results demonstrated that trigonelline reduced diabetic nephropathy and insulin resistance in T2DM rats through PPAR-γ.

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Antioxidant, antilipidemic and antidiabetic effects of ficusin with their effects on GLUT4 translocation and PPARγ expression in type 2 diabetic rats

Cited by 49 publications

References 37 publications

Anti-Diabetic Effects of Zhuoduqing Formula, a Chinese Herbal Decoction, on a Rat Model of Type 2 Diabetes

Anti-Diabetic Effects of Zhuoduqing Formula, a Chinese Herbal Decoction, on a Rat Model of Type 2 Diabetes

Sperm Proteomics Analysis of Diabetic Induced Male Rats as Influenced by Ficus carica Leaf Extract

Trigonelline reduced diabetic nephropathy and insulin resistance in type�2 diabetic rats through peroxisome proliferator‑activated receptor‑γ

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