Antioxidant capacity in obstructive sleep apnea patients

Impact of Obstructive Sleep Apnea on Myocardial Tissue Perfusion in Patients With ST-Segment Elevation Myocardial Infarction

“…Christou et al showed that antioxidant capacity in patients with severe OSA (AHI >20 events/h) was negatively correlated with AHI. 36 Total antioxidant capacity and antioxidant vitamin (vitamins A and E) plasma levels were significantly reduced in patients with OSA compared to control subjects. 37 Faure et al demonstrated a decrease in albumin antioxidant properties in non-obese OSA patients when compared with control subjects.…”

Oxidative stress and oxidant signaling in obstructive sleep apnea and associated cardiovascular diseases

“…Levels of small molecule antioxidants such as ascorbic acid, tocopherols, carotenoids, and flavonoids are often lower in diseases associated with oxidative stress. While comprehensive examinations of antioxidant levels in OSA have not been rigorously performed, one study by Christou et al [29] assessed the antioxidant capacity in the blood of 14 patients with severe OSA (apnea/hypopnea index of N20) compared with controls using the Trolox Equivalent Antioxidant Capacity assay. This colorimetric assay is based on the scavenging of the 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) radical converting it into a colorless product.…”

Contribution of Autonomic Nervous System to the Hypertension Induced by Obstructive Sleep Apnea

“…Reactive oxygen species (ROS) and reactive nitrogen species (RNS), and pro-inflammatory agents have been proposed as mediators of cardiovascular and cognitive alterations in OSA patients [7,13,33,45,52,65,102] and animal models [10, 15-18, 44, 48, 82, 84, 106]. Studies performed in OSA patients and animals exposed to intermittent hypoxia showed that the hypoxia-reoxygenation episodes produce systemic oxidative stress due to the accumulation of ROS and RNS, which are potential sources of cellular damage.…”