Antioxidant Capacity of 2-(3,5-diaryl-4,5-dihydro-1H-pyrazol-1-yl)-4-phenylthiazoles

Silva, F. A.N.; Pizzuti, Lucas; Quina, Frank H.; Souza, Stefânia P. de; Rosales, Pauline F.; Siqueira, Geonir M.; Pereira, Cláudio Martin Pereira de; Barros, S. B. M.; Rivelli, Diogo Pineda

doi:10.2174/157018010792929513

Cited by 4 publications

(2 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There were recent reports of the regiospecific synthesis of many pyrazole derivatives under mild conditions via (3+2) cyclocondensations between 1,3-dielectrophiles and hydrazines [16,17,18]. In addition, there have been reports of the synthesis of a series of 5-aryl-1-carboxamidino-3-styryl-4,5-dihydro-1 H -pyrazole derivatives from the cyclocondensation of 1,5-diaryl-1,4-pentadien-3-ones and aminoguanidine hydrochloride and their application in the synthesis of new 2-(5-aryl-3-styryl-4,5-dihydro-1 H- pyrazol-1-yl)-4-(trifluoromethyl)pyrimidines [19].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Anti-Candida, Anti-Enzyme Activity and Cytotoxicity of 3,5-Diaryl-4,5-dihydro-1H-pyrazole-1-carboximidamides

et al. 2014

View full text Add to dashboard Cite

Because of the need for more effective and less harmful antifungal therapies, and interest in the synthesis of new carboximidamides, the goal of this study was to determine the antifungal and anti-enzyme activities of some new pyrazole carboximidamides and their cytotoxicity. For this purpose, tests were performed to evaluate: minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC); production of proteinases and phospholipase, and cytotoxicity of the extracts. Data were analyzed by ANOVA and Tukey Tests (α = 5%). The results were: MIC and MFC ≥ 62.5 μg/mL (C. albicans, C. parapsilosis, C. famata, C. glabrata, and Rhodotorula mucillaginosa) and OPEN ACCESSMolecules 2014, 19 5807 MIC and MFC ≥ 15.6 μg/mL (C. lipolytica). The values of proteinase and phospholipase (Pz) of C. albicans before and after exposure to the compounds were: 0.6 (±0.024) and 0.2 (±0.022) and 0.9 (±0.074) and 0.3 (±0.04), respectively. These proteinase results were not significant (p = 0.69), but those of phospholipase were (p = 0.01), and 15.6 μg/mL was the most effective concentration. The cytotoxicity means were similar among the tests (p = 0.32). These compounds could be useful as templates for further development through modification or derivatization to design more potent antifungal agents. Data from this study provide evidence that these new pyrazole formulations could be an alternative source for the treatment of fungal infections caused by Candida. However, a specific study on the safety and efficacy of these in vivo and clinical trials is still needed, in order to evaluate the practical relevance of the in vitro results.

show abstract

Section: Introductionmentioning

confidence: 99%

“…Furthermore, the synthesis under mild conditions of novel 3,5-diaryl-4,5-dihydro-1 H -pyrazole-1-carboximidamides by the reaction of chalcones with aminoguanidine hydrochloride in KOH has been described [20]. In addition to the antioxidant capacity of pyrazoles [16,17] several potential applications should be investigated.…”

Section: Introductionmentioning

confidence: 99%

Anti-Candida, Anti-Enzyme Activity and Cytotoxicity of 3,5-Diaryl-4,5-dihydro-1H-pyrazole-1-carboximidamides

et al. 2014

View full text Add to dashboard Cite

show abstract

Antioxidant Properties and UV Absorbance Pattern of Mycosporine‐Like Amino Acids Analogs Synthesized in an Environmentally Friendly Manner

Andreguetti

Stein

Pereira

et al. 2013

J Biochem & Molecular Tox

View full text Add to dashboard Cite

In current study, we report efficient and clean procedure for preparing mycosporine-like amino acids (MMAs) analogs and evaluate their ultraviolet absorbance properties and antioxidant activities. The ultraviolet radiation absorbance patterns of the compounds were recorded and then used to define their molar absorptivities. The antioxidant activities were assessed using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging and superoxide radical scavenging assays. Eight of nine compounds showed good activity against superoxide radicals, as only one of the analogs exhibited a measurable IC50 in the DPPH assay.

show abstract

Antifungal Susceptibility, Exoenzyme Production and Cytotoxicity of Novel Oximes against Candida

et al. 2013

View full text Add to dashboard Cite

Novel oximes were synthesized, their in vitro antifungal activity against Candida was evaluated and their cytotoxicity was determined. The procedure used for the synthesis of the oximes is aligned with the current green chemistry trend; water is employed as the solvent in this reaction. The minimum inhibitory and minimum fungicidal concentrations of the oximes were evaluated using the CLSI M27-A3 method. The influence of these compounds on the inhibition of the production of hydrolytic enzymes, phospholipase and proteinase by Candida was also investigated. The compounds showed a good ability to inhibit phospholipase, with a 50 % reduction in most cases. However, the tested compounds did not affect proteinase. The current results showed a substantial reduction in the phospholipase production, which suggests that compounds of this class may interfere with host infection and disease progression. The oximes examined showed lower fungicidal activities than fluconazole but interfered significantly with the expression of phospholipase. Some of the oximes included in this study could be a suitable matrix for the development of novel antifungal compounds.

show abstract

Antioxidant Capacity of 2-(3,5-diaryl-4,5-dihydro-1H-pyrazol-1-yl)-4-phenylthiazoles

Cited by 4 publications

References 15 publications

Anti-Candida, Anti-Enzyme Activity and Cytotoxicity of 3,5-Diaryl-4,5-dihydro-1H-pyrazole-1-carboximidamides

Anti-Candida, Anti-Enzyme Activity and Cytotoxicity of 3,5-Diaryl-4,5-dihydro-1H-pyrazole-1-carboximidamides

Antioxidant Properties and UV Absorbance Pattern of Mycosporine‐Like Amino Acids Analogs Synthesized in an Environmentally Friendly Manner

Antifungal Susceptibility, Exoenzyme Production and Cytotoxicity of Novel Oximes against Candida

Contact Info

Product

Resources

About