Antioxidant capacity of sesamol in Caenorhabditis elegans model system

Abstract

Senescence is a general and irreversible process which depends on both inherent (free radical and age) and external (Ultraviolet irradiation) factors. Antioxidants and other natural compounds like plant and plant products are widespread use for their medicinal and therapeutic values. The present study focuses on the role of sesamol which has been used to delay the effects of photoaging using model nematode Caenorhabditis elegans (C. elegan) by measuring the longest life, average life, reproductive capacity, and the variation of reactive oxygen of C. elegans under different stress conditions. The result showed that 200 µg·mL−1 sesamol significantly extended the life of C. elegans, that is, the mean lifespan of the treatment groups were 43.3% longer than control group. Meanwhile, sesamol significantly prolonged the lifespan of C. elegans under heat stress, ultraviolet irradiation stress, and oxidative stress. Above all, sesamol could be used as potential antioxidant compounds which will be of greater significance for health-based research. Graphical Abstract