Antioxidant constituents of Nymphaea caerulea flowers

Agnihotri, Vijai K.; ElSohly, Hala N.; Khan, Shabana I.; Smillie, Troy J.; Khan, Ikhlas A.; Walker, Larry

doi:10.1016/j.phytochem.2008.04.009

Cited by 48 publications

(32 citation statements)

References 20 publications

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“…Agnihotri et al evaluated antioxidant activity of isosalipurposide (12), isolated from the Nymphaea caerulea flowers, by determining the inhibition of reactive oxygen species (ROS) generation in myelomonocytic HL-60 cells. This compound was considered more active (IC 50 = 1.7 µg/ml) than vitamin C (IC 50 = 1.95 µg/ml) [22].…”

Section: Antioxidant Activitymentioning

confidence: 99%

Trends in Utilization of the Pharmacological Potential of Chalcones

Batovska

Todorova²

2010

CCP

299

206

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Chalcones (1,3-diaryl-2-propen-1-ones) are open chain flavonoids that are widely biosynthesized in plants. They are important for the pigmentation of flowers and, hence, act as attractants to the pollinators. As flavonoids, chalcones also play an important role in defense against pathogens and insects. A longstanding scientific research has shown that chalcones also display other interesting biological properties such as antioxidant, cytotoxic, anticancer, antimicrobial, antiprotozoal, antiulcer, antihistaminic and anti-inflammatory activities. Some lead compounds with various pharmacological properties have been developed based on the chalcone skeleton. Clinical trials have shown that these compounds reached reasonable plasma concentrations and did not cause toxicity. For these reasons, chalcones became an object of continued interest in both academia and industry. Nowadays, several chalcones are used for treatment of viral disorders, cardiovascular diseases, parasitic infections, pain, gastritis, and stomach cancer, as well as like food additives and cosmetic formulation ingredients. However, much of the pharmacological potential of chalcones is still not utilized. The purpose of this review is to describe the recent efforts of scientists in pharmacological screening of natural and synthetic chalcones, studying the mechanisms of chalcone action and relevant structure-activity relationships. Put together, these activities aimed at synthesis of pharmacologically active chalcones and their analogs.

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Section: Antioxidant Activitymentioning

confidence: 99%

Trends in Utilization of the Pharmacological Potential of Chalcones

Batovska

Todorova²

2010

CCP

299

206

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“…Hazelnuts also have phytochemicals of different classes including tannins, carotenoids, and polyphenols. These metabolites have excellent antioxidative properties and ability to reduce risk of certain type of cancers, coronary heart disease (CHD), cardiovascular disease (CVD), stroke, atherosclerosis, osteoporosis, inflammation and other oxidative stress associated ailments (Watson 2003;Hertog et al 1993;Ness and Powles 1997;Shahidi and Naczk 2004;Agnihotri et al 2008). The prevalent phenolics accumulates in Corylus avellana kernels and its byproducts are catechin, gallic acid, sinapic acid, caffeic acid, p-coumaric acid, ferulic acid, their esters and flavonoids (Shahidi et al 2007;Del Rio et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant properties and UPLC–MS/MS profiling of phenolics in jacquemont’s hazelnut kernels (Corylus jacquemontii) and its byproducts from western Himalaya

Kumar

Koundal

et al. 2016

J Food Sci Technol

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A rapid and selective analytical method was developed to simultaneously quantify seven polyphenolic compounds (gallic acid, catechin, epicatechin, quercetin, kaempferol, syringic acid and p-coumaric acid). 15 phenolics of diverse groups in 80 % ethanolic extracts of jacquemont's hazelnut (Corylus jacquemontii) kernels and its byproducts from western Himalaya using ultra-performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS/MS) were identified. The developed analytical method showed excellent linearity, repeatability and accuracy. Total phenols concentrations were found to be 4446, 1199 and 105 mg gallic acid equivalent (GAE)/Kg of dried extract for jacquemont's hazelnut skin, hard shell and kernels respectively. Antioxidant potential of defatted, raw jacquemont's hazelnut skin, hard shell and kernel extracts assessed by 2,2 0 -azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS), 2,2 0 -diphenyl-1-picrylhydrazyl (DPPH) methods were increased in a dose-dependent manner. The IC 50 values were observed as 23.12, 51.32, 136.46 and 45.73, 63.65, 169.30 lg/ml for jacquemont's hazelnut skin, hard shell, kernels by DPPH and ABTS assays, respectively. The high phenolic contents in jacquemont's hazelnut skin contributed towards their free radical scavenging capacities.

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“…The Nymphaeaceae also called water lilies have a broad range of flower colors and are living on the banks of lakes and rivers, distributed in tropical areas around the world [14–16]. A number of species of Nymphaea in Nepal, India, and China are thought to act as functional drug plants [17].…”

Section: Introductionmentioning

confidence: 99%

Synergistic Effect and Antiquorum Sensing Activity ofNymphaea tetragona(Water Lily) Extract

Hossain

Park

Kim

et al. 2014

BioMed Research International

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Salmonellosis is a common and widely distributed food borne disease where Salmonella typhimurium is one of the most important etiologic agents. The purpose of this study was to investigate the antimicrobial activity of Nymphaea tetragona alone and in combination with antibiotics against S. typhimurium. It also aimed to assess the plant for quorum sensing inhibition (QSI) activity and to identify the bioactive compounds. The antibacterial activities of the extract were assessed using broth microdilution method. Disk agar diffusion method was employed to determine the QSI and bioactive compounds were identified by GC-MS analysis. Ethyl acetate fraction of N. tetragona extract (EFNTE) demonstrated good antimicrobial activity (MIC 781 μg/mL) against 4 strains out of 5. FIC index ranged from 0.375 to 1.031 between EFNTE/tylosin and 0.515 to 1.250 between EFNTE/streptomycin against S. typhimurium. Among all extracts, EFNTE and butanol fraction more significantly inhibited pigment production of C. violaceum. Polyphenols were identified as major compound of EFNTE and butanol fraction. These results indicate that combination among N. tetragona extract and antibiotics could be useful to combat drug-resistance Salmonella infections and polyphenols are promising new components from N. tetragona that warrant further investigation as a candidate anti-Salmonella agent and quorum sensing inhibitor.

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Antioxidant constituents of Nymphaea caerulea flowers

Cited by 48 publications

References 20 publications

Trends in Utilization of the Pharmacological Potential of Chalcones

Trends in Utilization of the Pharmacological Potential of Chalcones

Antioxidant properties and UPLC–MS/MS profiling of phenolics in jacquemont’s hazelnut kernels (Corylus jacquemontii) and its byproducts from western Himalaya

Synergistic Effect and Antiquorum Sensing Activity ofNymphaea tetragona(Water Lily) Extract

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