Antioxidant consumption during exercise in intermittent claudication

Khaira, H.S.; Maxwell, Scott; Shearman, CP

doi:10.1002/bjs.1800821225

Cited by 43 publications

(22 citation statements)

References 18 publications

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“…Oxygen-derived free radicals are involved in various diseases affecting the extremities [1][2][3][4][5]. In free radicalrelated processes, lipid peroxidation occurs followed by cellular damage.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Soft Tissue Repair Capacity after Oxygen-Derived Free Radical-Induced Damage in One Hindlimb of the Rat

Laan¹,

Oyen²,

Verhofstad³

et al. 1997

Journal of Surgical Research

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Section: Discussionmentioning

confidence: 99%

“…thritis [1], diabetic neuropathy [2], compartment syn drome [3], interm ittent claudication [4], and athero sclerosis [5]. However, next to free radicals, other in flammatory mediators [6,7] and alterations in cellular energy metabolism [8] contribute to the tissue damage in these processes.…”

mentioning

confidence: 99%

Soft Tissue Repair Capacity after Oxygen-Derived Free Radical-Induced Damage in One Hindlimb of the Rat

Laan¹,

Oyen²,

Verhofstad³

et al. 1997

Journal of Surgical Research

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“…The beneficial effect of antioxidant intervention in claudicants has been suggested previously (22) and was explored further in this work by combining traditional measurements in IR research with 1 H-NMR spectroscopy-based metabonomics. The study design involved 14 claudicants and three healthy volunteers, who were subjected to a walking test before and after the intake of vitamins and after a washout period.…”

Section: Introductionmentioning

confidence: 94%

Measurement of ischaemia–reperfusion in patients with intermittent claudication using NMR‐based metabonomics

et al. 2008

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Intermittent claudication has proved to be a good in vivo model for ischaemia-reperfusion. For assessment of ischaemia-reperfusion damage, the known biochemical markers all have disadvantages with respect to sensitivity and interference with other physiological events. In this work, we studied the metabolic effects of ischaemia-reperfusion in patients with intermittent claudication, and the effects of vitamin C and E intervention, using both traditional biochemical measurements and 1H-NMR-based metabonomics on urine and plasma. The 1H-NMR spectra were subjected to multivariate modelling using principal components discriminant analysis, and the observed clusters were validated using joint deployment of univariate analysis of variance and Tukey-Kramer honestly significant difference (HSD) testing. The study involved 14 patients with intermittent claudication and three healthy volunteers, who were monitored during a walking test, before and after a vitamin C/E intervention, and after a washout period. The effect of exercise was only observable for a limited number of biochemical markers, whereas 1H NMR revealed an effect in line with anaerobic ATP production via glycolysis in exercising (ischaemic) muscle of the claudicants. Thus, the beneficial effect of vitamins C and E in claudicants was more pronounced when observed by metabonomics than by traditional biochemical markers. The main effect was more rapid recovery from exercise to resting state metabolism. Furthermore, after intervention, claudicants tended to have lower concentrations of lactate and glucose and several other citric acid cycle metabolites, whereas acetoacetate was increased. The observed metabolic changes in the plasma suggest that intake of vitamin C/E leads to increased muscle oxidative metabolism.

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“…In CAD, the evidence points towards an increased oxidative stress associated with acute exercise; however, this effect may be dependent on induced ischaemia as detected hy a positive exercise treadmill test [42], The results from studies of exercised claudicants are variable. Khaira et al [43] showed a decrease in antioxidant concentration, although aspirin use was not apparent. Contrary to this, Lewis et al [44] identified elevated total antioxidant capacity in aspirin-treated claudicants after exercise.…”

Section: Discussionmentioning

confidence: 97%

Treadmill exercise in claudicants on aspirin results in improved antioxidant status but only minimal platelet activation

et al. 2005

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The consequence of exercise on platelets remains controversial and adverse effects may result from repeated ischaemia reperfusion injury. We investigated platelet activation (platelet P-selectin (PS), and activated glycoprotein (Gp) IIb/IIIa), platelet-monocyte aggregates (PMA) and total plasma antioxidant status (TPAS) in claudicants after exercise. Twenty claudicants, taking 75 mg of aspirin daily, were subjected to repeated treadmill testing (3 km/h, 10% inclination). Blood was sampled before and after exercise. Activated GpIIb/IIIa, PS and PMA were quantified with flow cytometry. TPAS was quantified using a decolourisation assay. Percent positive cells for PS (pre-exercise 3.76% vs. 40 min post-exercise 4.10%; P < 0.05) and platelet-monocyte aggregates (pre-exercise: 25.31% vs. 40 min post-exercise 26.99%; P < 0.05) were significantly higher after exercise. Relative median fluorescence (RMF) for activated GpIIb/IIIa was significantly higher 40 min after exercise (pre-exercise: 3.04 vs. 40 min post-exercise: 4.01; P < 0.05). TPAS was significantly higher post-exercise (pre-exercise: 1.31 mmol/l vs. 1 min post-exercise: 1.40 mmol/l and 40 min post-exercise: 1.38 mmol/l; P < 0.01). Following moderate exercise, 'aspirin treated claudicants' show marginal platelet activation, PMA formation and a favourable improvement in antioxidant status. Further studies are required to assess the effect of additional antiplatelet agents and the significance of platelet-monocyte interactions. The possibility that aspirin contributes to the TPAS changes following exercise needs to be investigated.

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Antioxidant consumption during exercise in intermittent claudication

Cited by 43 publications

References 18 publications

Soft Tissue Repair Capacity after Oxygen-Derived Free Radical-Induced Damage in One Hindlimb of the Rat

Soft Tissue Repair Capacity after Oxygen-Derived Free Radical-Induced Damage in One Hindlimb of the Rat

Measurement of ischaemia–reperfusion in patients with intermittent claudication using NMR‐based metabonomics

Treadmill exercise in claudicants on aspirin results in improved antioxidant status but only minimal platelet activation

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