Antioxidant cuttlefish collagen hydrolysate against ethyl carbamate-induced oxidative damage

Du, Bowei; Deng, Guiya; Zaman, Fakhar; Ma, Hongan; Li, Xuejuan; Chen, Jialiang; Li, Tianyu; Huang, Yaqin

doi:10.1039/d0ra08487e

Cited by 7 publications

(6 citation statements)

References 47 publications

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“…Alpha lipoic acid also ameliorated cobalt-induced liver injury via inhibiting ferroptosis [ 130 ]. In addition, ammonia [ 131 ], lead [ 132 ], mercuric chloride [ 133 ], ethyl carbamate [ 134 , 135 ], di (2-ethylhexyl) phthalate [ 136 ], aflatoxin B1 [ 137 ], and acrylamide [ 138 ] could cause liver injury by inducing ferroptosis. And there are corresponding NAC to prevent or treat pollutants-induced liver injury ( Table 1 ).…”

Section: Nac Treat Liver Disease By Targeting Ferroptosismentioning

confidence: 99%

Ferroptosis in Liver Disease: Natural Active Compounds and Therapeutic Implications

Wu,

Zhu,

Liu

et al. 2024

Antioxidants

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Ferroptosis is an emerging type of regulated cell death usually accompanied by the accumulation of ferrous ions (Fe2+) and lipid peroxides. As the metabolic hub of the body, the liver is crucial for iron storage and lipid metabolism. The liver seems to be closely related to ferroptosis through iron and lipid metabolism. Liver disease greatly threatens host health, and exploring effective interventions is essential. Mounting studies have demonstrated that ferroptosis is one of the possible pathogenic mechanisms involved in liver disease. Targeting ferroptosis may provide a promising opportunity for treating liver disease. However, drugs targeting ferroptosis are extremely limited. Therefore, it is an urgent need to develop new and safe ferroptosis regulators. Natural active compounds (NAC), especially those derived from traditional Chinese medicine, have recently shown great therapeutic potential in liver disease via modulating ferroptosis-related genes or pathways. Here, we outline the molecular mechanism of ferroptosis and systematically summarize the regulatory function of NAC on ferroptosis in liver disease. Finally, we discuss the application prospects and potential problems concerning NAC as ferroptosis regulators for managing liver disease.

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Section: Nac Treat Liver Disease By Targeting Ferroptosismentioning

confidence: 99%

Ferroptosis in Liver Disease: Natural Active Compounds and Therapeutic Implications

Wu,

Zhu,

Liu

et al. 2024

Antioxidants

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“…In addition, collagen gel application reduced infection and accelerated epithelialization. Furthermore, it has been demonstrated that the abundant methionine residues within the peptide chain of marine collagen hydrolysate serve as active sites for antioxidant activity [ 193 ]. Besides, it could scavenge ROS by inhibiting the ferroptosis signal pathway and depleting antioxidant GSH molecules, thereby enhancing cell viability when applied to tissue injury and aiding in the resistance to oxidation-induced cell death.…”

Section: Marine Structural Protein-based Nanocarriersmentioning

confidence: 99%

Marine biomaterials in biomedical nano/micro-systems

Wang,

Chen,

Wang

et al. 2023

J Nanobiotechnol

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Marine resources in unique marine environments provide abundant, cost-effective natural biomaterials with distinct structures, compositions, and biological activities compared to terrestrial species. These marine-derived raw materials, including polysaccharides, natural protein components, fatty acids, and marine minerals, etc., have shown great potential in preparing, stabilizing, or modifying multifunctional nano-/micro-systems and are widely applied in drug delivery, theragnostic, tissue engineering, etc. This review provides a comprehensive summary of the most current marine biomaterial-based nano-/micro-systems developed over the past three years, primarily focusing on therapeutic delivery studies and highlighting their potential to cure a variety of diseases. Specifically, we first provided a detailed introduction to the physicochemical characteristics and biological activities of natural marine biocomponents in their raw state. Furthermore, the assembly processes, potential functionalities of each building block, and a thorough evaluation of the pharmacokinetics and pharmacodynamics of advanced marine biomaterial-based systems and their effects on molecular pathophysiological processes were fully elucidated. Finally, a list of unresolved issues and pivotal challenges of marine-derived biomaterials applications, such as standardized distinction of raw materials, long-term biosafety in vivo, the feasibility of scale-up, etc., was presented. This review is expected to serve as a roadmap for fundamental research and facilitate the rational design of marine biomaterials for diverse emerging applications. Graphical Abstract

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“…Another category of marine collagen falls under invertebrate animals. Antioxidant collagen hydrolysates isolated from invertebrate animals including squid [48], rhopilema hispidum, sea cucumber and cuttlefish, have been found with a variety of biomedical activities [34,49,50]. They can also serve as marine source of antioxidant collagen hydrolysates for medicinal use.…”

Section: Species As Collagen Sourcesmentioning

confidence: 99%

“…For example, the optimal extraction conditions for a high antioxidant collagen hydrolysate from cuttlefish skin using alcalase were based on the single-factor analysis. A common process condition optimization method, Box-Behnken design, was used to optimize the operating variables such as temperature, pH, and enzyme quantity [34]. Moreover, a combination ABTS radical scavenging of enzymes leverages the advantages of multiple enzymes, resulting in higher antioxidant activities of collagen hydrolysates.…”

Section: The Design Of the Hydrolysis Reaction To Obtain Antioxidant ...mentioning

confidence: 99%

Developments for collagen hydrolysates as a multifunctional antioxidant in biomedical domains

Deng,

Huang,

Jiang

et al. 2023

Collagen & Leather

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Antioxidant collagen hydrolysates refers to the peptides mixture with antioxidant properties identified from hydrolyzed collagen. Due to its specific structural, biological and physicochemical properties, collagen hydrolysates have been explored as a multifunctional antioxidant in the biomedical field. In this review, we summarize recent advances in antioxidant collagen hydrolysates development. Initially, the preparation process of antioxidant collagen hydrolysates is introduced, including the production and separation methods. Then the effects and the mechanisms of amino acid composition and collagen peptide structure on the antioxidant activity of collagen hydrolysates are reviewed. Finally, the applications of antioxidant collagen hydrolysates in biomedical domains are summarized, with critical discussions about the advantages, current limitations and challenges to be resolved in the future. Graphical abstract

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Antioxidant cuttlefish collagen hydrolysate against ethyl carbamate-induced oxidative damage

Abstract: Collagen hydrolysate against EC-induced oxidative damage.

Cited by 7 publications

References 47 publications

Ferroptosis in Liver Disease: Natural Active Compounds and Therapeutic Implications

Ferroptosis in Liver Disease: Natural Active Compounds and Therapeutic Implications

Marine biomaterials in biomedical nano/micro-systems

Developments for collagen hydrolysates as a multifunctional antioxidant in biomedical domains

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