Antioxidant, cyclooxygenase and topoisomerase inhibitory compounds from Apium graveolens Linn. seeds

Ligusticum chuanxiong as a potential neuroprotectant for preventing serum deprivation-induced apoptosis in rat pheochromocytoma cells: Functional roles of mitogen-activated protein kinases

“…Among these compounds, ferulic acid is ubiquitous in plants and is known for its free radical scavenging (Zhang et al, 2003) and anti-inflammatory activities (Sakai et al, 1997). Senkyunolide is known to have anticyclooxygenase activity (Momin and Nair, 2002), while ligustilide has an antiproliferative effect (Kobayashi et al, 1992). Tetramethylpyrazine is perhaps the most intensively studied compound whose biological functions involve vasodilatation and antiplatelet activity (Sheu et al, 2000;Hintz and Ren, 2003).…”

Reduction in hypercholesterolemia and risk of cardiovascular diseases by mixtures of plant food extract: a study on plasma lipid profile, oxidative stress and testosterone in rats

“…Phenolic compounds have been reported to have antioxidant, anti-inflammatory and hypocholesterolemic activity (Löliger, 1991). Celery seeds showed antioxidant and cyclooxygenase inhibitory activity reflecting anti-inflammatory effects due to the presence of the phenolic compounds sedanolide and senkyunolide-N (Momin and Nair, 2002). Also the methanol extract of celery seeds showed significant anti-gout activity in vivo, which usually involves high oxidative stress and inflammation (Mohamed and Al-okbi, 2008).…”

“…Examples of plants foods that may possess antioxidant and hypolipidemic effects are tomato and carrots which are rich in carotenoids (Fuhrman et al, 1997), wheat germ and rice bran oil which are rich in tocopherols, phytosterols, unsaturated fatty acids and other oil soluble active constituents (Ardiansyah et al, 2006;khatoon and Gopalakrishna, 2004;Wang and Johnson, 2001;Rustan et al, 1993). Thyme and celery seed contain high levels of phenolic compounds (Naemura et al, 2008;Momin and Nair, 2002). If bioactive extracts from the abovementioned plant foods were mixed together, they may act synergistically as powerful anti atherogenic and hypocholesterolemic nutraceuticals.…”

Antinociceptive and anti-inflammatory effects of isolated fractions fromApium graveolensseeds in mice

“…In Iranian traditional medicine, celery seeds are used to treat rheumatoid arthritis, gout, and kidney complaints (Zargari, 1990). The seeds are reported to possess antinociceptive, antiinflammatory properties (Lewis, 1985;Al-Hindawi et al, 1989;Atta & Alkofahi, 1998) and antioxidant properties (Lewis et al, 1985;Momin et al, 2002). A previous study in our laboratory has revealed that hydroalcohol extract of celery seeds has anti-inflammatory and antinociceptive activity (Nasri et al, 2007).…”