Antioxidant defense system induced by cysteine-stabilized peptide fraction of aqueous extract of Morinda lucida leaf in selected tissues of Plasmodium berghei -infected mice

Adewole, Kayode Ezekiel; Adebayo, Joseph O.

doi:10.1016/s2095-4964(17)60354-6

Cited by 15 publications

(11 citation statements)

References 51 publications

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“…Cuttlefish-purified peptides can obviously inhibit the oxidation process of linoleic acid, effectively protect the DNA damage induced by • OH radicals, and have no toxic effect to cells at higher concentrations [ 159 ]. In addition, some studies have confirmed that PAs have certain potential in the treatment of cancer [ 275 ], malaria [ 276 ], hypertension [ 277 , 278 ] and blood diseases [ 224 ], and are expected to become therapeutic drugs. Bioactive peptides derived from rapeseed protein (LY, RALP, GHS) can significantly inhibit the secretion of NO, il-6 and tumor necrosis factor stimulated by lipopolysaccharide, and then repair the damage of spontaneously hypertensive cells caused by oxidative stress, which has potential application value in protecting the body from oxidative and inflammatory damage [ 279 ].…”

Section: Potential Application Of Food-derived Pasmentioning

confidence: 99%

Advances on Food-Derived Peptidic Antioxidants—A Review

et al. 2020

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The oxidation process is considered to be the main reason behind human aging, human degenerative diseases and food quality degradation. Food-derived peptidic antioxidants (PAs) have wide sources and great activity, and have broad application prospects in removing excess reactive oxygen species in the body, anti-aging and preventing and treating diseases related to oxidative stress. On the other hand, PAs are expected to inhibit the lipid peroxidation of foods and increase the stability of the food system in the food industry. However, the production pathways and action mechanism of food-derived PAs are diverse, which makes it is difficult to evaluate the performance of PAs which is why the commercial application of PAs is still in its infancy. This article focuses on reviewing the preparation, purification, and characterization methods of food-derived PAs, and expounds the latest progress in performance evaluation and potential applications, in order to provide an effective reference for subsequent related research of PAs.

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Section: Potential Application Of Food-derived Pasmentioning

confidence: 99%

Advances on Food-Derived Peptidic Antioxidants—A Review

et al. 2020

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“…Plant-derived antioxidants are used for taste enhancement and as health fortification agents [69], such as liver protectants [70], memory enhancers [71], and supple-ments to promote healthy cells [72,73]. In therapeutics, plant-derived antioxidant peptides are effective in treating blood disorders [74], hypertension [75,76] and malaria [77,78]. Among the plants' sources, cereals have been extensively studied and found to exert substantial antioxidant potential to alleviate oxidative stress.…”

Section: Antioxidative Peptidesmentioning

confidence: 99%

Exploring Molecular Insights of Cereal Peptidic Antioxidants in Metabolic Syndrome Prevention

et al. 2021

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The prevalence of metabolic syndrome (MetS) is presently an alarming public health problem globally. Oxidative stress has been postulated to be strongly correlated with MetS, such as type 2 diabetes, obesity, hypertension, cardiovascular diseases, and certain cancers. Cereals are important staple foods which account for a huge proportion of the human diet. However, owing to recent growing demand and the search for natural antioxidants for the prevention and management of MetS, cereal peptides have gained increasing attention for developing functional ingredients or foods with substantial antioxidant properties. This review explores the current production techniques for cereal peptidic antioxidants and their potential mechanism of action in the prevention and management of MetS.

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“…In most cases, the drugs used to treat CVDs are anticoagulant molecules that inhibit or delay coagulation by acting on one or more coagulation factors. Coagulation and fibrinolysis are interrelated enzymatic processes that, together with mechanisms involving the vascular Pharmaceutics 2021, 13, 1153 2 of 12 wall and platelets, keep the blood flowing within the blood vessels. An inadequate activation of coagulation or the uncontrolled activation of fibrinolysis can generate hemorrhagic disorders, such as in Von Willebrand's disease, hemophilia, or hemolytic anemia [6].…”

Section: Introductionmentioning

confidence: 99%

Purification and Identification of Novel Antioxidant Peptides Isolated from Geoffroea decorticans Seeds with Anticoagulant Activity

et al. 2021

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Geoffroea decorticans is a xerophilous deciduous tree present in most arid forests of southern South America, which is commonly used in traditional medicine. The seeds of this tree have been previously investigated for their singular chemical composition, but their protein content has been poorly investigated. Herein, we report the isolation, purification, and characterization of a set of thermostable peptides derived from Geoffroea decorticans seeds (GdAPs) with strong antioxidant and anticoagulant activities. The most potent antioxidant peptides showed a half maximal inhibitory concentration (IC50) of 35.5 ± 0.3 µg/mL determined by 1,1-diphenyl-2-picrylhydrazyl (DPPH). They also caused a dose-dependent prolongation of the aPTT clotting time with an IC50 value of ~82 µg/mL. Interestingly, MALDI-TOF/MS analysis showed the presence of three major peptides with low molecular weights of 2257.199 Da, 2717.165 Da, and 5422.002 Da. The derived amino-acid sequence of GdAPs revealed their unique structural features, exhibiting homology with various proteins present in the genome of Arachis hypogaea. All in all, our data suggest a direct applicability of GdAPs for pharmaceutical purposes.

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Antioxidant defense system induced by cysteine-stabilized peptide fraction of aqueous extract of Morinda lucida leaf in selected tissues of Plasmodium berghei -infected mice

Cited by 15 publications

References 51 publications

Advances on Food-Derived Peptidic Antioxidants—A Review

Advances on Food-Derived Peptidic Antioxidants—A Review

Exploring Molecular Insights of Cereal Peptidic Antioxidants in Metabolic Syndrome Prevention

Purification and Identification of Novel Antioxidant Peptides Isolated from Geoffroea decorticans Seeds with Anticoagulant Activity

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