Antioxidant Defense System: Regulation of Metabolic Processes, Genetic Determinants, and Methods of Determination

Nikitina, O. A.; Darenskaya, M. A.; Semenova, Natalya; Колесникова, Л. И.

doi:10.1134/s1990519x2301011x

Cited by 1 publication

(2 citation statements)

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“…IBD is often researched from a genetic point of view as well [ 39 ]. Many genes control OS development [ 40 , 41 ]. Unlike many other processes, the relationship between genes and OS is bilateral.…”

Section: The Cooperation Of the Microbiome And Os In Disease Developm...mentioning

confidence: 99%

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Gut Microbiome Interactions with Oxidative Stress: Mechanisms and Consequences for Health

Semenova,

Garashchenko,

Kolesnikov

et al. 2024

Pathophysiology

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Understanding how gut flora interacts with oxidative stress has been the subject of significant research in recent years. There is much evidence demonstrating the existence of the microbiome–oxidative stress interaction. However, the biochemical basis of this interaction is still unclear. In this narrative review, possible pathways of the gut microbiota and oxidative stress interaction are presented, among which genetic underpinnings play an important role. Trimethylamine-N-oxide, mitochondria, short-chain fatty acids, and melatonin also appear to play roles. Moreover, the relationship between oxidative stress and the gut microbiome in obesity, metabolic syndrome, chronic ethanol consumption, dietary supplements, and medications is considered. An investigation of the correlation between bacterial community features and OS parameter changes under normal and pathological conditions might provide information for the determination of new research methods. Furthermore, such research could contribute to establishing a foundation for determining the linkers in the microbiome–OS association.

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Section: The Cooperation Of the Microbiome And Os In Disease Developm...mentioning

confidence: 99%

“…On the other hand, this damage could be provoked by OS itself. Moreover, OS may negatively influence the proliferation of cells [ 16 , 18 , 40 , 41 , 42 ]. The genetic foundation of the interconnection between the microbiome and OS has also been investigated.…”

Section: The Cooperation Of the Microbiome And Os In Disease Developm...mentioning

confidence: 99%

Gut Microbiome Interactions with Oxidative Stress: Mechanisms and Consequences for Health

Semenova,

Garashchenko,

Kolesnikov

et al. 2024

Pathophysiology

View full text Add to dashboard Cite

show abstract

Antioxidant Defense System: Regulation of Metabolic Processes, Genetic Determinants, and Methods of Determination

Cited by 1 publication

References 40 publications

Gut Microbiome Interactions with Oxidative Stress: Mechanisms and Consequences for Health

Gut Microbiome Interactions with Oxidative Stress: Mechanisms and Consequences for Health

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