Antioxidant effect of hydroxytyrosol (DPE) and Mn2+ in liver of cadmium-intoxicated rats

Casalino, Elisabetta; Calzaretti, Giovanna; Sblano, Cesare; Landriscina, Vito; Tecce, Mario Felice; Landriscina, C

doi:10.1016/s1532-0456(02)00180-1

Cited by 52 publications

(46 citation statements)

References 55 publications

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“…The OOMWW phenolic fraction is characterized by a great complexity, as demonstrated by Bianco et al (2003); one of the most abundant and very interesting compounds from a nutritional point of view is hydroxytyrosol, which has been widely studied, demonstrating its antioxidant and beneficial health properties as well as its good bioavailability. Hydroxytyrosol scavenges free radicals (Visioli et al, 1999) and inhibits human low-density lipoprotein (LDL) oxidation (Aruoma et al, 1998;Casalino et al, 2002;Deiana et al, 1999). For economic reasons, OOMWW is usually concentrated in evaporation ponds and left to dry throughout the summer season (Borja et al, 1992;Benitez et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

Antioxidant activity of olive oil mill wastewater obtained from different thermal treatments

Giuffré¹,

Sicari²,

Piscopo³

et al. 2012

Grasas y Aceites

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Section: Discussionmentioning

confidence: 99%

Antioxidant activity of olive oil mill wastewater obtained from different thermal treatments

Giuffré¹,

Sicari²,

Piscopo³

et al. 2012

Grasas y Aceites

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“…Many antioxidants have been attempted to be used in the intervention of Cd (II) toxicity, for instance, asmelatonin (Karbownik et al, 2001), quercetin (Hu et al, 2001), hydroxytyrosol (Casalino et al, 2002), coenzyme Q10 (Eybl et al, 2002), beta-carotene (El-Demerdash et al, 2004), curcumin (Eybl et al, 2004), vitamin E (Nemmiche et al, 2007) and diphenyl diselenide (Borges et al, 2008). Our group has demonstrated that endomorphin 1, the endogenous μ-opioid receptor agonists (Zadina et al, 1997), can block the toxicity of Cd and protect mice liver from oxidative damage (Gong et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Protective effect of caffeic acid phenethyl ester against cadmium-induced renal damage in mice

Gong

Chen

et al. 2012

J. Toxicol. Sci.

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-Cadmium (Cd) is classified as an environmental pollutant and human carcinogen. Caffeic acid phenethyl ester (CAPE), a biological active component of honeybee propolis extracts, has been used as a folk medicine with no harmful effects on normal cells. Here we investigated the beneficial effect of CAPE on Cd-induced renal damage in mice. Since renal damage induced by Cd (II) is related to oxidative stress, lipid peroxidation (LPO), protein carbonyl (PCO), superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH) were evaluated. Moreover, the concentrations of Cd and zinc (Zn) in the kidney were analyzed. The intoxication of Cd (II) leads to the enhanced production of LPO and PCO, and the decrease of SOD activity and GSH level, probably due to the serious oxidative stress. However, the activities of CAT in the Cd (II)-induced group showed an elevated tendency, probably relating to an adaptive-response to the oxidative damage. The co-administration of CAPE can attenuate the oxidative stress caused by the intoxication of Cd and restore the altered antioxidant defense system. Based on our data, it is proposed that CAPE may involve in the protection of renal damage induced by Cd (II) owing to its antioxidant capacity and anti-inflammatory effect.

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“…Manganese exerts protective effects in experimental cadmium intoxication (Goehring and Klaassen, 1985;Kotyzová et al, 1990;Kotyzová and Eybl, 2004;Casalino et al, 2002). Manganese is an essential element at physiological levels.…”

Section: Introductionmentioning

confidence: 99%

The influence of curcumin and manganese complex of curcumin on cadmium-induced oxidative damage and trace elements status in tissues of mice

et al. 2006

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Curcumin (diferuoyl methane) from turmeric is a well-known biologically active compound. It has been shown to ameliorate oxidative stress and it is considered to be a potent cancer chemopreventive agent. In our previous study the antioxidative effects of curcumin in cadmium exposed animals were demonstrated. Also manganese exerts protective effects in experimental cadmium intoxication. The present study examined the ability of the manganese complex of curcumin (Mn-curcumin) and curcumin to protect against oxidative damage and changes in trace element status in cadmium-intoxicated male mice. Curcumin or Mn-curcumin were administered at equimolar doses (0.14 mmol/kg b.w.) for 3 days, by gastric gavages, dispersed in methylcellulose. One hour after the last dose of antioxidants, cadmium chloride (33 micromol/kg) was administered subcutaneously. Both curcumin and Mn-curcumin prevented the increase of hepatic lipid peroxidation -- expressed as MDA level, induced by cadmium intoxication and attenuated the Cd-induced decrease of hepatic GSH level. No change in hepatic glutathione peroxidase or catalase activities was found in Cd-exposed mice. A decreased GSH-Px activity was measured in curcumin and Mn-curcumin alone treated mice. Neither curcumin nor Mn-curcumin treatment influenced cadmium distribution in the tissues and did not correct the changes in the balance of essential elements caused by Cd-treatment. The treatment with Mn-curcumin increased the Fe and Mn content in the kidneys of both control and Cd-treated mice and Fe and Cu content in the brain of control mice. In conclusion, regarding the antioxidative action, introducing manganese into the curcumin molecule does not potentiate the studied effects of curcumin.

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Antioxidant effect of hydroxytyrosol (DPE) and Mn2+ in liver of cadmium-intoxicated rats

Cited by 52 publications

References 55 publications

Antioxidant activity of olive oil mill wastewater obtained from different thermal treatments

Antioxidant activity of olive oil mill wastewater obtained from different thermal treatments

Protective effect of caffeic acid phenethyl ester against cadmium-induced renal damage in mice

The influence of curcumin and manganese complex of curcumin on cadmium-induced oxidative damage and trace elements status in tissues of mice

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