Antioxidant effect of peony seed oil on aging mice

Han, Xiao-Miao; Wu, Su-xi; Wu, Mei‐Fang; Yang, Xuefeng

doi:10.1007/s10068-017-0225-9

Cited by 17 publications

(8 citation statements)

References 18 publications

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“…Moreover, DHA‐enriched phosphatidylcholine (DHA‐PC) and EPA‐enriched phosphatidylcholine (EPA‐PC) could moderate cognitive deficits in high‐fat diet‐fed senescence‐accelerated mouse prone 8 mice by restraining Aβ generation, inhibiting oxidative stress and apoptosis, down‐regulating inflammatory response, and enhancing neurotrophic activity 26 . Researches have reported that PSO shows therapeutic effects on anti‐oxidant, 27 hypoglycemic, 23 hypolipidemic, 28 and anti‐aging functions 27 . However, whether PSO can improve the cognitive deficits associated with AD remains unknown.…”

Section: Introductionmentioning

confidence: 99%

Peony seed oil ameliorates neuroinflammation-mediated cognitive deficits by suppressing microglial activation through inhibition of NF-κB pathway in presenilin 1/2 conditional double knockout mice

Gao

Wang

Zhao

et al. 2021

Journal of Leukocyte Biology

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Chronic neuroinflammation has been shown to exert adverse influences on the pathology of Alzheimer's disease (AD), associated with the release of abundant proinflammatory mediators by excessively activated microglia, causing synaptic dysfunction, neuronal degeneration, and memory deficits. Thus, the prevention of microglial activation‐associated neuroinflammation is important target for deterring neurodegenerative disorders. Peony seed oil (PSO) is a new food resource, rich in α‐linolenic acid, the precursor of long chain omega‐3 polyunsaturated fatty acids, including docosahexaenoic acid and eicosapentaenoic acid, which exhibit anti‐inflammatory properties by altering cell membrane phospholipid fatty acid compositions, disrupting lipid rafts, and inhibiting the activation of the proinflammatory transcription factor NF‐κB. However, few studies have examined the anti‐neuroinflammatory effects of PSO in AD, and the relevant molecular mechanisms remain unclear. Presenilin1/2 conditional double knockout (PS cDKO) mice display obvious AD‐like phenotypes, such as neuroinflammatory responses, synaptic dysfunction, and cognitive deficits. Here, we assessed the potential neuroprotective effects of PSO against neuroinflammation‐mediated cognitive deficits in PS cDKO using behavioral tests and molecular biologic analyses. Our study demonstrated that PSO suppressed microglial activation and neuroinflammation through the down‐regulation of proinflammatory mediators, such as inducible NOS, COX‐2, IL‐1β, and TNF‐α, in the prefrontal cortex and hippocampus of PS cDKO mice. Further, PSO significantly lessened memory impairment by reversing hyperphosphorylated tau and synaptic proteins deficits in PS cDKO mice. Importantly, PSO's therapeutic effects on cognitive deficits were due to inhibiting neuroinflammatory responses mediated by NF‐κB signaling pathway. Taken together, PSO may represent an effective dietary supplementation to restrain the neurodegenerative processes of AD.

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Section: Introductionmentioning

confidence: 99%

Peony seed oil ameliorates neuroinflammation-mediated cognitive deficits by suppressing microglial activation through inhibition of NF-κB pathway in presenilin 1/2 conditional double knockout mice

Gao

Wang

Zhao

et al. 2021

Journal of Leukocyte Biology

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“…The increase of essential amino acid content in rice, especially lysine content, can significantly improve the nutritional value of rice. Studies have shown that the increase of important nutrients in food can significantly promote the health of the body (Shen & Wu, 2017;Han et al, 2017;Wu et al, 2017). It can be seen that spraying a suitable concentration of the compound nutrient solution during a suitable growth period of rice is a good way to increase the essential amino acid content of rice and improve its nutritional value.…”

Section: Resultsmentioning

confidence: 99%

Determination and Evaluation of Se-Rich High-Quality Rice Produced by Compound Nutrient Solution

Wu¹,

Ying-xi²,

Han³

et al. 2020

JAS

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Rice is one of the most important food crops in the world. Its biggest flaw is the low content of protein and essential amino acids, which severely limits its nutritional value. In order to produce high-quality rice with rich Se, we sprayed different concentrations of compound nutrient solution (containing Se (selenium), amino acid compound, zinc and boron) on the rice at different growth stages; and then determined the main nutrient content of their polished rice. The results showed that spraying low concentration compound nutrient solution (Each liter contained 20 mg of Se, 333 mg of complex amino acids, 33 mg of zinc and 33 mg of boron) to rice in the heading stage produced rice with the highest total starch and fat content and lower amylose content. Spraying high concentration compound nutrient solution to rice during the filling stage produced rice with the highest Se content. Multiple sprays of compound nutrient solution produced rice with low protein and low starch. Spraying low concentration compound nutrient solution on rice in milky stage significantly increased the content of protein, total starch, fat, all essential amino acids (Lysine increased by more than 57%), amylopectin and Se in rice; significantly reduced amylose content; significantly improved the nutritional value and taste quality of rice. The conclusion is that spraying low concentration compound nutrient solution on rice in the milky stage can produce rice with the highest content of protein and essential amino acids, higher content of total starch, fat and Se, and the lowest amylose content; significantly improve the nutritional value and taste quality of rice. The technical solution can comprehensively and effectively improve the nutritional value and flavor quality of rice, and has great development and application value.

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“…Several antioxidants have been reported to be associated with inhibition of cellular senescence [29,30,31]. To examine whether histochrome affects cellular senescence, we investigated the long-term effect of histochrome treatment on an in vitro culture of hCPCs.…”

Section: Resultsmentioning

confidence: 99%

Therapeutic Cell Protective Role of Histochrome under Oxidative Stress in Human Cardiac Progenitor Cells

et al. 2019

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Cardiac progenitor cells (CPCs) are resident stem cells present in a small portion of ischemic hearts and function in repairing the damaged heart tissue. Intense oxidative stress impairs cell metabolism thereby decreasing cell viability. Protecting CPCs from undergoing cellular apoptosis during oxidative stress is crucial in optimizing CPC-based therapy. Histochrome (sodium salt of echinochrome A—a common sea urchin pigment) is an antioxidant drug that has been clinically used as a pharmacologic agent for ischemia/reperfusion injury in Russia. However, the mechanistic effect of histochrome on CPCs has never been reported. We investigated the protective effect of histochrome pretreatment on human CPCs (hCPCs) against hydrogen peroxide (H2O2)-induced oxidative stress. Annexin V/7-aminoactinomycin D (7-AAD) assay revealed that histochrome-treated CPCs showed significant protective effects against H2O2-induced cell death. The anti-apoptotic proteins B-cell lymphoma 2 (Bcl-2) and Bcl-xL were significantly upregulated, whereas the pro-apoptotic proteins BCL2-associated X (Bax), H2O2-induced cleaved caspase-3, and the DNA damage marker, phosphorylated histone (γH2A.X) foci, were significantly downregulated upon histochrome treatment of hCPCs in vitro. Further, prolonged incubation with histochrome alleviated the replicative cellular senescence of hCPCs. In conclusion, we report the protective effect of histochrome against oxidative stress and present the use of a potent and bio-safe cell priming agent as a potential therapeutic strategy in patient-derived hCPCs to treat heart disease.

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Antioxidant effect of peony seed oil on aging mice

Cited by 17 publications

References 18 publications

Peony seed oil ameliorates neuroinflammation-mediated cognitive deficits by suppressing microglial activation through inhibition of NF-κB pathway in presenilin 1/2 conditional double knockout mice

Peony seed oil ameliorates neuroinflammation-mediated cognitive deficits by suppressing microglial activation through inhibition of NF-κB pathway in presenilin 1/2 conditional double knockout mice

Determination and Evaluation of Se-Rich High-Quality Rice Produced by Compound Nutrient Solution

Therapeutic Cell Protective Role of Histochrome under Oxidative Stress in Human Cardiac Progenitor Cells

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