Antioxidant Effect of Swimming Training and Royal Jelly Consumption in the Hippocampus Tissue of Rats With Alzheimer’s Disease

Hasanloei, Awat; Salamat, Khalid Mohamadzadeh; Hoseini, Seyed Ali

doi:10.34172/hmj.2022.11

Cited by 2 publications

(1 citation statement)

References 22 publications

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“…Adult female albino Wistar rats (approximately 8–10 weeks old, 200–250 g) [ 22 , 23 ] were purchased from the Pasteur Institute of Iran, North Research Center (Amol, Iran) [ 24 ]. Rats were kept in an insulated room with a 12-h light/dark cycle at an ambient temperature of 22 ± 3°C and relative humidity of 52 ± 5% and were fed adequately and appropriately [ 25 , 26 ].…”

Section: Methodsmentioning

confidence: 99%

Effect of Rosa damascena Extract on Rat Model Alzheimer’s Disease: A Histopathological, Behavioral, Enzyme Activities, and Oxidative Stress Study

Hejazian

Hosseini

Taravati

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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The purpose of the current study is to investigate the effect of aquatic Rosa damascena extract against the oxidative damage induced by aluminum chloride intoxication in Alzheimer’s model of Wister rats. Rats were divided randomly into seven groups (n = 10). Control group received no treatment, sham group received distilled water orally, aluminum group (AL) was administered AlCl3 (100 mg/kg) orally, extract 1 and 2 groups were treated with only aqueous R. damascena extract (DRE) (500 and 1000 mg/kg), and treatment 1 and 2 groups received aqueous R. damascena extract (500 and 1000 mg/kg) and AlCl3 (100 mg/kg) orally. The brain tissues were sampled for histopathological examination, and biochemical analysis was conducted for estimating the enzyme activities of acetylcholinesterase and catalase (CAT), the levels of GSH and MDA, and ferric reducing antioxidant power. According to the results of behavioral tests, AL administration showed a reduction in spatial memory and remarkably increased the time needed for reaching the invisible platform. The administration of Al-induced oxidative stress and an increase of the enzyme activity of AChE. Al administration increased AChE level from 1.176 ± 0.173 to 3.62 ± 0.348, which was a significant rise. However, treating with the extract at the dose of 1000 mg/kg downregulated it to 1.56 ± 0.303. Administration of the R. damascene extract caused an increased level of catalase and glutathione levels in treatment groups, attenuated MDA level, and regulated AChE activity. Our results illustrate that administration of R. damascene extract has a protective effect against the oxidative damage induced by AlCl3 intoxication in Alzheimer’s model.

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Section: Methodsmentioning

confidence: 99%

Effect of Rosa damascena Extract on Rat Model Alzheimer’s Disease: A Histopathological, Behavioral, Enzyme Activities, and Oxidative Stress Study

Hejazian

Hosseini

Taravati

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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Angiogenic Effects of Aerobic Training and Royal Jelly Consumption with Emphasis on the Role of miR-126 and miR-210 in the Aortic Artery of Ovariectomized Diabetic Rats

Zangiband,

Mohamadzadeh Salamat,

Azizbeigi

et al. 2024

Asian J Sports Med

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Background: Cardiovascular complications in postmenopausal diabetic women are significantly higher than in their healthy peers. Although the beneficial effects of exercise interventions and consumption of foods rich in antioxidants on angiogenesis have been established, the synergistic effects of exercise training and royal jelly (RJ) consumption on angiogenesis in ovariectomized diabetic patients are still not well understood. Objectives: This study investigated the angiogenic effects of aerobic training (AT) and royal jelly (RJ) consumption, with an emphasis on the role of miR-126 and miR-210 in the aortic artery of ovariectomized diabetic (OVXD) rats. Methods: Thirty female OVXD rats were divided into five groups: OVXD control, Sham (Sh), RJ, AT, and AT + RJ. Additionally, six healthy rats were selected as the healthy control group (HC) to evaluate the effects of modeling on variables. Groups 4 and 5 underwent aerobic training for eight weeks, five sessions per week, with an intensity of 55 - 75% of VO2max. Groups 3 and 5 received 100 mg/kg/day of RJ. A one-way ANOVA test was used to analyze VEGF, eNOS, miR-126, and miR-210 (α = 0.05). Results: Vascular endothelial growth factor, eNOS, and miR-210 levels in the AT, RJ, and AT + RJ groups were higher than in the OVXD group (P ≤ 0.05). Although miR-126 levels in the RJ and AT + RJ groups were higher than in the OVXD group (P ≤ 0.05), the effects of AT and RJ separately on increasing VEGF and eNOS were more favorable than the combined effect of AT + RJ. Conclusions: While both AT and RJ supplementation individually increase markers of vascular angiogenesis, the simultaneous effects of these two interventions seem to moderate this mechanism.

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Antioxidant Effect of Swimming Training and Royal Jelly Consumption in the Hippocampus Tissue of Rats With Alzheimer’s Disease

Cited by 2 publications

References 22 publications

Effect of Rosa damascena Extract on Rat Model Alzheimer’s Disease: A Histopathological, Behavioral, Enzyme Activities, and Oxidative Stress Study

Effect of Rosa damascena Extract on Rat Model Alzheimer’s Disease: A Histopathological, Behavioral, Enzyme Activities, and Oxidative Stress Study

Angiogenic Effects of Aerobic Training and Royal Jelly Consumption with Emphasis on the Role of miR-126 and miR-210 in the Aortic Artery of Ovariectomized Diabetic Rats

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