Antioxidant Effects of an Aqueous Extract of Ilex paraguariensis

Schinella, Guillermo Raúl; Troiani, G.; Dávila, Valeria A.; Buschiazzo, Perla M. de; Tournier, Horacio

doi:10.1006/bbrc.2000.2293

Cited by 139 publications

(127 citation statements)

References 26 publications

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“…membranes (liposomes) and verified the occurrence of the protective effect. Schinella, et al, (2000) investigated the antioxidant properties of aqueous extract of I. paraguariensis St. Hil TM in rat liver microsomes systems using free radical generators and found that the extract inhibited enzymatic and non-enzymatic, concentration dependent lipid peroxidation, with IC 50 values of 18 µg⋅mL -1 and 28 µg⋅mL -1 respectively. Oral and topic administration of mate tea reduced the damage DNA, lipid peroxidation and protein carbonylation in rats skin tissue induced by radiation UVA and UVB (Barg et al, 2014).…”

Section: Antioxidant Activity Of I Paraguariensis St Hil In Vivomentioning

confidence: 99%

Antioxidant potential of yerba mate (Ilex paraguariensis St. Hil.) extracts in Saccharomyces cerevisae deficient in oxidant defense genes

et al. 2016

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Yerba-mate (Ilex paraguariensis St. Hil) is mainly consumed as "chimarrão", a hot drink highly appreciated in Brazil, Argentina, Paraguay and Uruguay. This study evaluated the antioxidant potential of aqueous extracts of I. paraguariensis precipitated with ethanol. The leaves were processed as for tea product (TM) and oxidized (OX). The antioxidant potential was evaluated in cells of Saccharomyces cerevisiae deficient in antioxidant defense genes. Three strains evaluated were: a wild (EG) and two mutants (ctt1Δ e ctt1Δsod1Δ). These strains were pre-treated with the yerba-mate extracts (TM e OX) and submitted to oxidative stress induced by hydrogen peroxide. None of the extracts produced loss of cell viability. The extracts exerted antioxidant activity, protecting the strains (except sod1∆ctt1∆). The TM extract was more effective than OX. I. paraguariensis extracts showed a potential to be explored in the development of new products.

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Section: Antioxidant Activity Of I Paraguariensis St Hil In Vivomentioning

confidence: 99%

Antioxidant potential of yerba mate (Ilex paraguariensis St. Hil.) extracts in Saccharomyces cerevisae deficient in oxidant defense genes

et al. 2016

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“…19 In the human setting, we have demonstrated that fetuses exposed to a maternal diet rich in polyphenols in the third trimester show higher ductal velocities and lower pulsatility indexes (PIs), as well as larger right ventricles, than those exposed to minimal amounts of these substances. 15,16 The rationale for understanding the behavior of fetal ductal arteriosus flow dynamics after maternal ingestion of PRF in late pregnancy is that these substances have definite anti-inflammatory and antioxidant effects, largely reported in the literature, [20][21][22][23][24][25][26][27][28][29] based on the inhibition of cyclooxygenase-2 or other components of the metabolic cascade resulting in prostaglandins biosynthesis. These actions are similar to that involved in prostaglandin inhibition caused by NSAID.…”

Section: Introductionmentioning

confidence: 99%

Reversal of fetal ductal constriction after maternal restriction of polyphenol-rich foods: an open clinical trial

et al. 2011

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Objective: To test the hypothesis that maternal restriction of polyphenolrich foods (PRF), which, like non-steroidal anti-inflammatory drugs (NSAID), inhibit prostaglandin synthesis in the third trimester, reverse fetal ductal constriction (DC). Study Design:An open clinical trial of 51 third trimester fetuses with DC with no history of NSAID intake was designed. All mothers were submitted to a food frequency questionnaire and were oriented to withdrawl PRF, being reassessed after 3 weeks. Doppler parameters were assessed before and after discontinuation of these substances. A control group of 26 third trimester normal fetuses, with no ductus arteriosus (DA) constriction, in which no dietary intervention was offered, was reviewed after 3 weeks. Student's t-test and Wilcoxon's test were used.Result: Mean gestational age was 32±3 weeks (28 to 37 weeks). After discontinuation of PRF (X3 weeks), 48/51 fetuses (96%) showed complete reversal of DC, with decrease in mean ductal systolic velocity (1.74 ± 0.20 m s À1 to 1.31 ± 0.34 m s À1 , P<0.001), mean diastolic velocity (0.33±0.09 m s À1 to 0.21±0.07 m s À1 , P<0.001) and mean right to left ventricular dimension ratio (1.37 ± 0.26 to 1.12 ± 0.17, P<0.001) and increase in mean ductal pulsatility index (PI) (1.98 ± 0.36 to 2.46±0.23, P<0.001). Median daily maternal consumption of PRF was 286 mg per day and decreased after orientation to 0 mg per day, P<0.001. In the control group, with GA of 32±4 w (29-37 w), there was no significant differences in median daily maternal consumption of PRF, mean ductal systolic velocitiy, diastolic velocity, PI and right ventricular to left ventricular diameter ratio (RV/LV) ratio. Keywords: fetal ductal constriction; prostaglandins; pulmonary hypertension; polyphenol-rich foods Introduction Ductal constriction (DC) has long been related to inhibition of the prostaglandin synthesis pathway, mainly as a result of maternal intake of non-steroidal anti-inflammatory drugs (NSAID) in the third trimester of pregnancy. 1-5 Constriction of fetal ductus arteriosus (DA) is a risk factor for pulmonary hypertension in the newborn period, with its known severe consequences. [6][7][8][9][10][11] For several years, many reports have been discussing the high prevalence of DC in the absence of a known trigger effect. 11 It has been discussed that other extrinsic factors, in addition to NSAID, could be involved in the genesis of this important clinical situation. 1,12,13 We and others have already suggested that maternal ingestion of polyphenol-rich foods (PRF) in late pregnancy, such as herbal teas, grape juice, dark chocolate and others, could be associated to fetal DC. [14][15][16][17][18] Experimental studies in fetal lambs have supported this hypothesis, showing a cause and effect relationship of maternal consumption of green tea and other polyphenol-rich substances with constriction of fetal DA in the animal model. 19 In the human setting, we have demonstrated that fetuses exposed to a maternal diet rich in polyphenols in the third trimester show h...

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“…Several studies on yerba maté have reported the presence of xanthines such as caffeine and theobromine, saponines, and several phenolic compounds, mainly chlorogenic acids and dicaffeoylquinic acid derivatives (FILIP et al, 2000;SCHINELLA et al, 2000;RAMIREZ-MARES;BORTOLUZZI et al, 2006;GUGLIUCCI et al, 1996); Dudonne et al (2009) reported 200 mg gallic acid equivalents per g of powder extract and Bravo et al (2007) reported 45 mg caffeoyquinic acids per g of dry samples. It has also been reported that yerba maté extracts have an in vitro antioxidant capacity (AOC), which is due to the presence of polyphenolic compounds that have an antioxidant capacity equal to or higher than that of ascorbic acid and vitamin E (FILIP et al, 2000;SCHINELLA et al, 2000;RAMIREZ-MARES;GUGLIUCCI et al, 1996;GONZALEZ DE MEJIA et al, 2005).…”

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confidence: 99%

“…It has also been reported that yerba maté extracts have an in vitro antioxidant capacity (AOC), which is due to the presence of polyphenolic compounds that have an antioxidant capacity equal to or higher than that of ascorbic acid and vitamin E (FILIP et al, 2000;SCHINELLA et al, 2000;RAMIREZ-MARES;GUGLIUCCI et al, 1996;GONZALEZ DE MEJIA et al, 2005). Dudonné et al (2009) placed yerba maté aqueous extracts between the fifth plant extracts with higher antioxidant activity among 30 selected plants analyzed.…”

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confidence: 99%

A novel procedure to measure the antioxidant capacity of Yerba maté extracts

et al. 2012

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Yerba maté extracts have in vitro antioxidant capacity attributed to the presence of polyphenolic compounds, mainly chlorogenic acids and dicaffeoylquinic acid derivatives. DPPH is one of the most used assays to measure the antioxidant capacity of pure compounds and plant extracts. It is difficult to compare the results between studies because this assay is applied in too many different conditions by the different research groups. Thus, in order to assess the antioxidant capacity of yerba maté extracts, the following procedure is proposed: 100 µL of an aqueous dilution of the extracts is mixed in duplicate with 3.0 mL of a DPPH 'work solution in absolute methanol (100 µM.L-1), with an incubation time of 120 minutes in darkness at 37 ± 1 °C, and then absorbance is read at 517 nm against absolute methanol. The results should be expressed as ascorbic acid equivalents or Trolox equivalents in mass percentage (g% dm, dry matter) in order to facilitate comparisons. The AOC of the ethanolic extracts ranged between 12.8 and 23.1 g TE % dm and from 9.1 to 16.4 g AAE % dm. The AOC determined by the DPPH assay proposed in the present study can be related to the total polyphenolic content determined by the Folin-Ciocalteu assay.

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Antioxidant Effects of an Aqueous Extract of Ilex paraguariensis

Cited by 139 publications

References 26 publications

Antioxidant potential of yerba mate (Ilex paraguariensis St. Hil.) extracts in Saccharomyces cerevisae deficient in oxidant defense genes

Antioxidant potential of yerba mate (Ilex paraguariensis St. Hil.) extracts in Saccharomyces cerevisae deficient in oxidant defense genes

Reversal of fetal ductal constriction after maternal restriction of polyphenol-rich foods: an open clinical trial

A novel procedure to measure the antioxidant capacity of Yerba maté extracts

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