Antioxidant effects of Citharexylum spinosum in CCl4 induced nephrotoxicity in rat

Khan, Muhammad Rashid; Siddique, Fatima

doi:10.1016/j.etp.2010.09.009

Cited by 54 publications

(53 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The elevated levels of ALT, AST, ALP reported in the current study in animals treated with CCl 4 , indicated severe hepatic parenchymal cell injury and were in agreement with the previous reports [72]- [75]. Moreover, CCl 4 was found to induce oxidative stress in hepatic tissue leading to accumulation of free radicals and consequently decreased activities of hepatic antioxidant enzymes; SOD, CAT and GPx with increased level of MDA indicating the oxidative damage to the hepatic tissue caused by CCl 4 [76]- [78]. 4 .…”

Section: Discussionsupporting

confidence: 80%

Possible Synergistic Effect and Antioxidant Properties of Chitosan Nanoparticles and Quercetin against Carbon Tetrachloride-Induce Hepatotoxicity in Rats

El-Denshary¹,

Aljawish²,

El‐Nekeety³

et al. 2015

SNL

View full text Add to dashboard Cite

This study was conducted to prepare chitosan nanoparticles (CNPs), to determine their properties and to evaluate the synergistic protective role of CNPs alone or in combination with quercetin (Q) against oxidative stress and hepatotoxicity in rats. Female Sprague-Dawley rats were divided into 12 groups (7 rats/group) and were maintained on their respective diet for 3 weeks as follow: control group, the group treated with CCl4 (100 mg/kg b.w twice a week); the groups received CNPs at low and high doses (140 and 280 mg/kg b.w); the group received Q (50 mg/kg b.w); the groups received CNPs at the low or high doses plus Q and the groups treated with CCl4 plus Q and/or CNPs at the two tested doses. Blood and liver samples were collected at the end of experiment period for biochemical and histological studies. The results indicated that chitosan showed deacetylation degree of 17.5% and 19.2% and the molar mass average of monomer was 168.35 g/mol and 169.1 g/mol by UV and IR methods respectively. The particle size of CNPs was around 100 nm with a rough surface. The in vivo results revealed that CCl4 induced biochemical and histological changes typical to those reported in the literature. Animals treated with CNPs at the two tested doses alone or in combination with Q were comparable to the control. CNPs alone or plus Q succeeded to induce significant improvements in the biochemical parameters and histological picture of the liver in rats treated with CCl4. This improvement was in dose-dependent manner for CNPs and was * Corresponding author. E. S. El-Denshary et al. 37more pronounced in the group treated with the high dose plus Q. It could be concluded that both CNPs and Q could induce protection against hepatotoxicity. Consequently, CNPs was a promise candidate as drug delivery in liver diseases treatments.

show abstract

Section: Discussionsupporting

confidence: 80%

Possible Synergistic Effect and Antioxidant Properties of Chitosan Nanoparticles and Quercetin against Carbon Tetrachloride-Induce Hepatotoxicity in Rats

El-Denshary¹,

Aljawish²,

El‐Nekeety³

et al. 2015

SNL

View full text Add to dashboard Cite

show abstract

“…These pathological changes signify the potential damage to liver and kidney cells induced with CCl 4 treatment (Ogeturk et al, 2005). From the present study it is evident that elevation in plasma urea and creatinine levels can be attributed to the damage of nephron structural integrity (Khan and Siddique, 2012). It is well documented CCl 4 increased creatinine liver and kidney tissues (Simko et al, 1992).…”

Section: Discussionmentioning

confidence: 57%

Isolation of Astragaloside-IV and Cyclocephaloside-I from Astragalus gummifera and Evaluation of Astragaloside-IV on CCl4 Induced Liver Damage in Rats

Ranganath

Balakrishna

Pramila

et al. 2014

Asian J. of Biological Sciences

View full text Add to dashboard Cite

Two Cycloartane saponins, astragaloside-IV and cyclocephaloside-I, were isolated from the roots of Astragalus gummifera. Their structures were determined by utilizing 1D and 2D NMR experiments. Hepatoprotective effects of astragaloside-IV against carbon tetrachloride (CCl 4 ) induced nephrotoxicity and hepatotoxicity in rats was studied. The rats (200-230 g) of either sex were divided into 6 groups (6 rats each). Injection of a single dose of CCl 4 increases the level of serum AST, ALT, GGT, ALP and total bilirubin activities, decreases non-protein sulfhydryls (NP-SH) and total proteins (TPs), increases malondialdehyde (MDA) and produces changes in hepatic and nephritic tissue structure. Administration of doses of 25, 50 and 75 mg kgG 1 of astragaloside-IV reversed significantly (p<0.001) the liver diagnostic blood markers as well as stricture of nephrotoxicity and hepatotoxicity of the treated groups when compared to the control group. The present finding indicated that astragaloside-IV is an active hepatoprotective agent that restores the affected biochemical markers and nephritic and hepatic tissues.

show abstract

“…In our study we demonstrate that the inhibition of seed germination and the reduction of seedling elongation were not only related to the content in polyphenols of the extract (Table 2) but probably with the presence in all plant parts of one or more of phenol compound responsible for the activity (Inderjit, 1996;Khan and Siddique, 2012). In fact, we demonstrate that extracts containing low quantities in total phenol show a great inhibitor power and that the toxic metabolites are distributed in all plant parts in various concentrations (Harborne, 1977).…”

Section: Discussionmentioning

confidence: 73%

Allelopathic activity of extracts of Citharexylum spinosum L. from Tunisia

Ayeb-Zakhama¹,

Harzallah‐Skhiri²

2016

J. Plant Breed. Crop Sci.

View full text Add to dashboard Cite

Allelopathic potential of Citharexylum spinosum L. (Verbenaceae) an exotic tree introduced in Tunisia many years ago was evaluated. Organic extracts using hexane, ethyl acetate and methanol solvents together with aqueous extracts at different concentrations were prepared from different parts of the plant (roots, stems, leaves and flowers). Yields in the 12 organic extracts together with their phenol contents were reported. Leaves methanol extract showed the highest yield and amount in total phenols (6.43%; 617.93±1.12 mg gallic acid equivalent/100 g MS, respectively). All extracts were tested on germination and early growth of two crops: (Lactuca sativa L.) and (Triticum aestivum L.) and two weeds: (Peganum harmala L.) and (Silybum marianum L.). Twelve parameters were established and used to the principal components analysis (PCA) and the hierarchical clusters (HCA) analysis. Three groups of extracts were separated according to their allelopathic potentiality. Almost of organic extracts were totally opposed to seed germination of peganum and thistle.

show abstract

Antioxidant effects of Citharexylum spinosum in CCl4 induced nephrotoxicity in rat

Cited by 54 publications

References 27 publications

Possible Synergistic Effect and Antioxidant Properties of Chitosan Nanoparticles and Quercetin against Carbon Tetrachloride-Induce Hepatotoxicity in Rats

Possible Synergistic Effect and Antioxidant Properties of Chitosan Nanoparticles and Quercetin against Carbon Tetrachloride-Induce Hepatotoxicity in Rats

Isolation of Astragaloside-IV and Cyclocephaloside-I from Astragalus gummifera and Evaluation of Astragaloside-IV on CCl4 Induced Liver Damage in Rats

Allelopathic activity of extracts of Citharexylum spinosum L. from Tunisia

Contact Info

Product

Resources

About