Antioxidant effects of Genkwa flos flavonoids on Freund׳s adjuvant-induced rheumatoid arthritis in rats

Zhang, Chunfeng; Zhang, Suli; He, Xin; Yang, Xiaolin; Wu, Hai-Liang; Lin, Baoqin; Jiang, Cuiping; Wang, Jun; Yu, Chunhao; Yang, Zhonglin; Wang, Chong‐Zhi; Li, Ping; Yuan, Chun‐Su

doi:10.1016/j.jep.2014.03.046

Cited by 51 publications

(28 citation statements)

References 21 publications

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“…Antioxidants play an important role in relieving arthritis in rats (Zhang et al, 2014). Chronic administration of PSO in the present study caused a remarkable elevation of serum antioxidant levels and a marked inhibition of paw edema that could be attributed to its high content of the aforementioned antioxidants.…”

Section: Discussionsupporting

confidence: 48%

“…Overproduction of lipid peroxide oxidative stress marker, MDA, was noticed in AA rats (Zhang et al, 2014). AA was monitored by hind paw volume and high level of MDA.…”

Section: Discussionmentioning

confidence: 95%

“…Paw swelling, body weight loss and overproduction of serum TNF-α and MDA were reported as the main pathological signs in FCA-induced arthritis in rats (Zhang et al, 2014). Paw volume and ESR were evaluated as arthritic markers (Banji et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

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Anti-inflammatory activity of two varieties of pumpkin seed oil in an adjuvant arthritis model in rats

et al. 2017

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SUMMARY:The aim of the present research was to evaluate the anti-inflammatory activity of pumpkin seed oils (PSOs) of an Egyptian and European variety, in a rat model of adjuvant arthritis. Edema thickness, plasma tumor necrosis factor-α (TNF-α) and erythrocyte sedimentation rate (ESR) were determined as inflammatory biomarkers while malondialdehyde (MDA) and total antioxidant capacity (TAC) were assessed as indicative of oxidative stress. Chromosomal aberration, sperm shape abnormalities, and DNA fragmentations are cytogenetic parameters which aid in tracing inflammatory and oxidative activity. Phenolic contents and β-carotene were determined in PSOs. The results showed elevated ESR, plasma TNF-α, plasma MDA, liver cellular DNA fragmentation, bone marrow chromosomal aberration, sperm shape abnormalities with a reduction in plasma TAC and body weight gain in an adjuvant arthritis control compared to a healthy control. Administration of low and high doses of either Egyptian or European PSO improved all the aforementioned parameters with variable degrees.KEYWORDS: Adjuvant arthritis; Anti-inflammatory; β-Carotene; Phenolic contents; Pumpkin seed oils RESUMEN: Actividad antiinflamatoria de dos variedades de aceite de semillas de calabaza en un modelo de artritis adyuvante en ratas. El objetivo de la presente investigación fue evaluar la actividad antiinflamatoria de aceites de calabaza (PSOs) de variedades egipcia y europea, en un modelo de rata con artritis adyuvante. El espesor del edema, el factor de necrosis tumoral (TNF-α) y la velocidad de sedimentación eritrocitaria (ESR) se determinaron como biomarcadores inflamatorios, mientras que el malondialdehído (MDA) y la capacidad antioxidante total (TAC) fueron evaluados como indicativos de estrés oxidativo. La aberración cromosómica, las anomalías de la forma del esperma y las fragmentaciones del ADN son parámetros citogenéticos que ayudan a localizar la actividad inflamatoria y oxidativa. Se determinaron contenidos fenólicos y β-caroteno en PSOs. Los resultados mostraron elevado ESR, TNF-α plasmático, MDA plasmática, fragmentación del ADN del hígado, aberración cromosómica de la médula ósea, anomalías de la forma espermática con una reducción del TAC plasmático y un aumento del peso corporal en el control de la artritis adyuvante en comparación con el control sano. La administración de dosis bajas y altas de PSO egipcia o europea mejoró todos los parámetros mencionados en grados variables.

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Section: Discussionsupporting

confidence: 48%

“…Overproduction of lipid peroxide oxidative stress marker, MDA, was noticed in AA rats (Zhang et al, 2014). AA was monitored by hind paw volume and high level of MDA.…”

Section: Discussionmentioning

confidence: 95%

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Anti-inflammatory activity of two varieties of pumpkin seed oil in an adjuvant arthritis model in rats

et al. 2017

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“…Latest studies showed that flowers, which mostly contain flavonoid compounds, exhibit anti-inflammatory, analgetic and immunomodulatory activity (67). Flavonoid fraction extracted from the flowers of this plant, which is made of luteolin, apigenin, hydroxy genkwanin and genkwanin shows significant therapeutic effects on arthritis in mice, without obvious adverse effects (68). The methanol extract of flower D. genkwa buds exhibits an inhibitory effect on the production of nitrogen monoxide (NO) which has an important role in neurotransmission, blood pressure regulation and cell defense systems (69).…”

Section: Th E Plant Species Of the Genus Daphne: Pharmacology Screenimentioning

confidence: 99%

Plants from The Genus Daphne: A Review of its Traditional Uses, Phytochemistry, Biological and Pharmacological Activity

Sovrlić

Manojlović

2017

Serbian Journal of Experimental and Clinical Research

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“…Freund's complete adjuvant (FCA) was prepared by suspending heat-killed BCG in sterile mineral oil (10 mg/ml). Arthritis was induced by a single injection of 100 μl of FCA intradermally in the left hind footpad of each rat [13].…”

Section: Induction Of Aiamentioning

confidence: 99%

Ameliorative effect and potential mechanism of Ermiao san on adjuvant-induced arthritis in rats

Chen¹,

Feng²

2016

Trop. J. Pharm Res

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Antioxidant effects of Genkwa flos flavonoids on Freund׳s adjuvant-induced rheumatoid arthritis in rats

Cited by 51 publications

References 21 publications

Anti-inflammatory activity of two varieties of pumpkin seed oil in an adjuvant arthritis model in rats

Anti-inflammatory activity of two varieties of pumpkin seed oil in an adjuvant arthritis model in rats

Plants from The Genus Daphne: A Review of its Traditional Uses, Phytochemistry, Biological and Pharmacological Activity

Ameliorative effect and potential mechanism of Ermiao san on adjuvant-induced arthritis in rats

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