Antioxidant effects of ginger (Zingiber officinale Roscoe) against lead acetate-induced hepatotoxicity in rats

Attia, M. Z.

doi:10.5897/ajpp2013.3465

Cited by 33 publications

(24 citation statements)

References 71 publications

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“…Treatments with lead acetate were found to cause a significant increases in serum ALT, AST and ALP activities [51 &52]. Attia et al [53] reported increased activities of ALT and AST in rats during lead poisoning. Increasing levels of AST and ALT in the plasma of treated rats is mainly due to the leakage of these enzymes from the liver cytosol into the blood stream [54].…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective Effect of Sesame Oil against Lead Induced Liver Damage in Albino Mice: Histological and Biochemical Studies

Azab¹

2014

AJBIO

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Abstract:The liver performs many vital functions to eliminate toxins and harmful substances from the body. Hepatotoxic agents can react with the basic cellular components and consequently induce almost all types of liver lesions. The aim of this study was to investigate the possible hepatoprotective role of sesame oil against lead acetate induced hepatotoxicity in albino mice from the histological and biochemical aspects. In this study, thirty two adult male albino mice were used for this study and divided into four groups. The first group was control group, the 2 nd was the sesame oil group orally received sesame oil (5 ml/kg body wt.), the 3 rd group was the experimental and received lead acetate (500 mg /kg diet), the 4 th one co-administered lead acetate (500 mg/kg diet) with sesame oil (5 ml/kg body wt.) daily for 30 days. The livers were dissected out, weighted and specimens were taken and processed for light microscopic examinations. Blood samples were obtained for assessment of serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and γ-glutamyltransferase activities, serum total proteins and albumin. Results indicate that, in lead treated animals, there were severe structural damage in the liver. The hepatocytes appeared irregularly arranged with disorganization of hepatic architecture. The hepatocytes appeared large with light and foamy cytoplasm filled with numerous vacuole-like spaces. The nuclei appeared with pyknotic nuclei. The central vein appeared dilated and congested with massive hemorrhage extending to the nearby cells. Also, there were focal degenerative and necrotic changes along with inflammatory cell infiltration. Decrease in body weight and increase in liver weight were observed. Biochemically, the serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and γ-glutamyltransferase activities were increased and serum total proteins and albumin were decreased. Co-administration of sesame oil significantly improved the structural changes in the liver and also the serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and γ-glutamyltransferase activities were significantly declined and serum total proteins and albumin were elevated. Conclusion: It can be concluded that, the lead had adverse effects on the liver. Sesame oil showed effective hepatoprotective action against lead acetate induced hepatotoxicity in albino mice. So, the populations of high risk to lead should be advised to take sesame oil.

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Section: Discussionmentioning

confidence: 99%

Hepatoprotective Effect of Sesame Oil against Lead Induced Liver Damage in Albino Mice: Histological and Biochemical Studies

Azab¹

2014

AJBIO

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“…The results show data from 3 experiments, with ratios given as means ± SEM. paraben [Asnani and Verma, 2009], lead [Attia et al, 2013], alcohol [Shanmugam et al, 2010], and arsenite [Morakinyo et al, 2013]. These effects have been attributed to its antioxidant mechanisms through enhancement of the activity of the antioxidant enzymes (SOD, GPx, and CAT) and the content of nonenzymatic (glutathione and ascorbic acid) antioxidants.…”

Section: Ginger ( Z Officinalementioning

confidence: 99%

Protective Effect of Ginger (<b><i>Zingiber officinale</i></b> Roscoe) Extract against Oxidative Stress and Mitochondrial Apoptosis Induced by Interleukin-1β in Cultured Chondrocytes

Hosseinzadeh

Juybari

Fatemi

et al. 2017

Cells Tissues Organs

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Aims: The protective effects of ginger (Zingiber officinale Roscoe) extract on IL-1β-mediated oxidative stress and mitochondrial apoptosis were investigated in C28I2 human chondrocytes. Methods: The effects of various concentrations of ginger extract on C28I2 human chondrocyte viability were evaluated in order to obtain noncytotoxic concentrations of the drug by methylthiotetrazole assay. The cells were pretreated with 5 and 25 μg/mL ginger extract for 24 h, followed by incubation with IL-1β (10 ng/mL) for 24 h. The effects of ginger extract on IL-1β-induced intracellular reactive oxygen species (ROS) production and lipid peroxidation were examined. The mRNA expressions of antioxidant enzymes including catalase, superoxide dismutase-1, glutathione peroxidase-1, glutathione peroxidase-3, and glutathione peroxidase-4 were evaluated by reverse transcription polymerase chain reaction. The protein expressions of Bax, Bcl-2, and caspase-3 were analyzed by Western blotting. Results: No cytotoxicity was observed at any concentration of ginger extract in C28I2 cells. Ginger extract pretreatment remarkably increased the gene expression of antioxidant enzymes and reduced the IL-1β-induced elevation of ROS, lipid peroxidation, the Bax/Bcl-2 ratio, and caspase-3 activity. Conclusions: Ginger extract could considerably reduce IL-1β-induced oxidative stress and consequent mitochondrial apoptosis as the major mechanisms of chondrocyte cell death. These beneficial effects of ginger extract may be due to its antioxidant properties. It may be considered as a natural herbal product to prevent OA-induced cartilage destruction in the clinical setting.

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“…Fluoride exposure would induce both pathomorphological and metabolic changes in the liver. [20] In this study,it is seen that administration of fluoride to rats caused a significant increase in the level of lipid peroxidation as indicated by the significant increase in MDA. Our results also corroborate well with that of Shivarajashankara et al [21] who demonstrated that 100 ppm of fluoride increases the rate of lipid peroxidation in liver.…”

Section: Haematological Parametersmentioning

confidence: 85%

Study of Fluoride-Induced Haematological Alterations and Liver Oxidative Stress in Rats

Derouiche¹

2017

WJPPS

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Antioxidant effects of ginger (Zingiber officinale Roscoe) against lead acetate-induced hepatotoxicity in rats

Cited by 33 publications

References 71 publications

Hepatoprotective Effect of Sesame Oil against Lead Induced Liver Damage in Albino Mice: Histological and Biochemical Studies

Hepatoprotective Effect of Sesame Oil against Lead Induced Liver Damage in Albino Mice: Histological and Biochemical Studies

Protective Effect of Ginger (<b><i>Zingiber officinale</i></b> Roscoe) Extract against Oxidative Stress and Mitochondrial Apoptosis Induced by Interleukin-1β in Cultured Chondrocytes

Study of Fluoride-Induced Haematological Alterations and Liver Oxidative Stress in Rats

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