Antioxidant effects of methionine, α-lipoic acid, N-acetylcysteine and homocysteine on lead-induced oxidative stress to erythrocytes in rats

Çaylak, Emrah; Aytekin, Metin; Halifeoğlu, İhsan

doi:10.1016/j.etp.2007.11.004

Cited by 97 publications

(58 citation statements)

References 27 publications

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“…In this study, the increased TBARS level in brain, liver and kidney of lead exposed rats was statistically significant confirming previous studies (Caylak et al, 2008). However, after administrated with SGE, TBARS level obviously decreased in brain, liver and kidney of lead poisoning rats.…”

Section: Discussionsupporting

confidence: 91%

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Protective effect of Smilax glabra extract against lead-induced oxidative stress in rats

Xia

Liao

et al. 2010

Journal of Ethnopharmacology

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Section: Discussionsupporting

confidence: 91%

“…Pregnant women, children and city habitants are on the risk of lead intoxication (Caylak et al, 2008). The detection and prevention of lead toxicity have been a major international public health priority (Ahamed and Siddiqui, 2007).…”

Section: Introductionmentioning

confidence: 99%

Protective effect of Smilax glabra extract against lead-induced oxidative stress in rats

Xia

Liao

et al. 2010

Journal of Ethnopharmacology

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“…Decreased α-tocopherol concentrations were also reported in a study by Ergurhan-Ilhan et al (42) who examined apprentices exposed to low doses of lead (PbB = 7.9±5.2 μg/dl). Moreover, Caylak et al (44) showed decreased level of vitamin E in rats that were orally exposed to lead acetate.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Occupational Exposure to Lead on the Non-Enzymatic Antioxidant System

Dobrakowski¹,

Zalejska–Fiolka²,

Wielkoszyński³

et al. 2014

Med Pr

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Background: The role of non-enzymatic antioxidants, such as uric acid, albumin, bilirubin, and α-tocopherol, in lead poisoning remains unclear. Therefore, the aim of the study was to explore the association between occupational exposure to lead and nonenzymatic antioxidant concentrations in serum and plasma. Material and Methods: The study population consisted of 278 healthy male employees of lead-zinc plants, with 129 workers classified as having low lead exposure (blood lead level -PbB = 20-39.9 μg/dl) and 149 workers classified as having high lead exposure (PbB = 40-59.8 μg/dl). The control group was composed of 73 healthy male administrative workers. No one from this group had blood lead level or zinc protoporphyrin (ZPP) level greater than normal levels, being 10 μg/dl and 2.5 μg/g of hemoglobin, respectively. In addition to the levels of PbB and ZPP, serum levels of uric acid (UA), albumin, thiol groups of albumin, and bilirubin were determined. The ferric reducing ability of plasma (FRAP) and the plasma level of α-tocopherol were also evaluated. Results: Lead exposure indices were significantly elevated in the examined subgroups as compared with the controls. Serum uric acid levels were significantly elevated in both subgroups, particularly in the group with high exposure. Serum bilirubin concentration was significantly elevated in the group with high exposure compared with the control group, while in the group with low exposure, it showed only a non-significant trend towards an increase. In contrast, ferric-reducing ability of plasma was not significantly greater in the examined subgroups as compared with the control group. Nevertheless, levels of albumin, thiol groups of albumin, and α-tocopherol levels were significantly decreased in the exposed subgroups compared with the control group. Conclusions: Occupational exposure to lead interferes with the blood non-enzymatic antioxidant system. Med Pr 2014;65(4): [443][444][445][446][447][448][449][450][451]

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“…Methionine: Precursor of glutathione (200) ; precursor of S-adenosyl methionine (653) ; neural tube defects (654) ; colon cancer (410) ; cognitive impairment in situation of folate deficiency (653) ; antioxidant activity (655) ; lipotrope (239) Cystine: Hair and nail development (656,657) ; muscle wasting (658) ; antioxidant and cell signalling through reactive cysteine residues in proteins (659) Total fibre (18,46,58,266,660,661) :…”

Section: Appendixmentioning

confidence: 99%

New hypotheses for the health-protective mechanisms of whole-grain cereals: what is beyond fibre?

2010

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Epidemiological studies have clearly shown that whole-grain cereals can protect against obesity, diabetes, CVD and cancers. The specific effects of food structure (increased satiety, reduced transit time and glycaemic response), fibre (improved faecal bulking and satiety, viscosity and SCFA production, and/or reduced glycaemic response) and Mg (better glycaemic homeostasis through increased insulin secretion), together with the antioxidant and anti-carcinogenic properties of numerous bioactive compounds, especially those in the bran and germ (minerals, trace elements, vitamins, carotenoids, polyphenols and alkylresorcinols), are today well-recognised mechanisms in this protection. Recent findings, the exhaustive listing of bioactive compounds found in whole-grain wheat, their content in whole-grain, bran and germ fractions and their estimated bioavailability, have led to new hypotheses. The involvement of polyphenols in cell signalling and gene regulation, and of sulfur compounds, lignin and phytic acid should be considered in antioxidant protection. Whole-grain wheat is also a rich source of methyl donors and lipotropes (methionine, betaine, choline, inositol and folates) that may be involved in cardiovascular and/or hepatic protection, lipid metabolism and DNA methylation. Potential protective effects of bound phenolic acids within the colon, of the B-complex vitamins on the nervous system and mental health, of oligosaccharides as prebiotics, of compounds associated with skeleton health, and of other compounds such as a-linolenic acid, policosanol, melatonin, phytosterols and para-aminobenzoic acid also deserve to be studied in more depth. Finally, benefits of nutrigenomics to study complex physiological effects of the 'whole-grain package', and the most promising ways for improving the nutritional quality of cereal products are discussed. Whole-grain wheat: Bioactive compounds: Physiological mechanisms: Health IntroductionThere is growing evidence that whole-grain cereal products protect against the development of chronic diseases. The most important of these in terms of public health are obesity (1,2) , the metabolic syndrome (3,4) , type 2 diabetes (5,6) , CVD (7) and cancers (8 -12) . Whole-grain cereal consumption has also been shown to be protective against mortality, as was shown with inflammation-related death (i.e. noncardiovascular and non-cancer inflammatory diseases such as, for example, respiratory system diseases) (13) and with cancer and CVD (4,14,15) . These conclusions are supported by the effects of consuming refined cereal products (bread, pasta and rice), as these have been associated with an increased risk of digestive tract, pharynx, larynx and thyroid cancers in northern Italians (16) . However, an association between a lower risk of developing a chronic disease and a high whole-grain cereal consumption does not mean a direct causal relationship and provides no information about the physiological mechanisms involved.These metabolic diseases are related to our daily lifestyle, no...

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Antioxidant effects of methionine, α-lipoic acid, N-acetylcysteine and homocysteine on lead-induced oxidative stress to erythrocytes in rats

Cited by 97 publications

References 27 publications

Protective effect of Smilax glabra extract against lead-induced oxidative stress in rats

Protective effect of Smilax glabra extract against lead-induced oxidative stress in rats

The Effect of Occupational Exposure to Lead on the Non-Enzymatic Antioxidant System

New hypotheses for the health-protective mechanisms of whole-grain cereals: what is beyond fibre?

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