Antioxidant effects of simvastatin in primary and secondary prevention of coronary heart disease

Tavridou, Anna; Efthimiadis, A.; Efthimiadis, I.; Paschalidou, H.

doi:10.1007/s00228-006-0097-z

Cited by 23 publications

(13 citation statements)

References 22 publications

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“…It is interesting that, conventionally, the oral hypolipemiants used to hypercholesterolemia have had either a very small or no contribution in increasing HDL levels (Jones et al, 2003;Tavridou et al, 2006). In our study, a small and similar increase on HDL levels was detected neither in CG nor in 500 EG groups of hypercholesterolemic patients.…”

Section: Discussioncontrasting

confidence: 66%

Effects of Campomanesia xanthocarpa on biochemical, hematological and oxidative stress parameters in hypercholesterolemic patients

Klafke

Silva

Panigas

et al. 2010

Journal of Ethnopharmacology

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Section: Discussioncontrasting

confidence: 66%

Effects of Campomanesia xanthocarpa on biochemical, hematological and oxidative stress parameters in hypercholesterolemic patients

Klafke

Silva

Panigas

et al. 2010

Journal of Ethnopharmacology

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“…It has been demonstrated that simvastatin does not increase the lag time of the copper‐induced oxidation of LDL in vitro , whereas it reduces significantly the rate of oxidation [31]. Moreover, simvastatin can significantly reduce circulating ox‐LDL levels in subjects undergoing both primary and secondary prevention of CHD [32]. Simvastatin treatment in hyperlipidaemic patients decreased aldehyde production derived from lipoprotein oxidation [33].…”

Section: Discussionmentioning

confidence: 99%

Ezetimibe's effect on platelet aggregation and LDL tendency to peroxidation in hypercholesterolaemia as monotherapy or in addition to simvastatin

Hussein¹,

Minasian²,

Itzkovich³

et al. 2008

Brit J Clinical Pharma

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WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• Statins demonstrate a pleiotropic effect which contributes beyond the hypocholesterolaemic effect to prevent atherosclerosis. WHAT THIS STUDY ADDS• Ezetimibe has an antioxidative effect when given as monotherapy or as an add-on to the statin, simvastatin. AIMSTo investigate the effect of lowering low-density lipoproteincholesterol (LDL-C) on platelet aggregation and LDL tendency to peroxidation by ezetimibe alone or with simvastatin in hypercholesterolaemia. METHODSSixteen patients with LDL-C >3.4 mmol l -1 received ezetimibe for 3 months (Part I). Twenty-two patients on fixed simvastatin dose with LDL-C >2.6 mmol l -1 were enrolled (Part II). Part II patients continued simvastatin treatment 20 mg day -1 for 6 weeks, then received 20 mg day -1 simvastatin combined with ezetimibe 10 mg day -1 for another 6 weeks. The tendency of LDL to peroxidation measured by lag time in minutes required for initiation of LDL oxidation and by LDL oxidation at maximal point (plateau) was measured before and after ezetimibe treatment. RESULTSPart I: Ezetimibe 10 mg daily for 3 months decreased plasma LDL-C level 16% (P = 0.002), prolonged lag time to LDL oxidation from 144 Ϯ 18 min to 195 Ϯ 16 min (P < 0.001), decreasing maximal aggregation from 83 Ϯ 15% to 60 Ϯ 36% (P = 0.04). Part II: Serum level LDL-C decreased 23% (P = 0.02) and lag time in minutes to LDL oxidation was prolonged from 55.9 Ϯ 16.5 to 82.7 Ϯ 11.6 (P < 0.0001) using combined simvastatin-ezetimibe therapy. There were no differences in platelet aggregation. CONCLUSIONSEzetimibe was associated with decreased platelet aggregation and LDL tendency to peroxidation. Treatment with ezetimibe in addition to simvastatin has an additive antioxidative effect on LDL.

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“…Our observation is in concordance with other in vivo studies indicating that simvastatin can inhibit lipid peroxidation and tissue injury. 27,28 Meanwhile, evidence has been presented to show that simvastatin has antioxidant activity in vitro, particularly the inhibition of lipid peroxidation. 29,30 Thus, the fact that simvastatin protected cells from lipid peroxidation in the present study may have resulted from its anti-inflammatory and direct antioxidant activity.…”

Section: Discussionmentioning

confidence: 99%

Effects of Simvastatin on Lung Injury Induced by Ischaemia–Reperfusion of the Hind Limbs in Rats

Sun

et al. 2007

J Int Med Res

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We investigated whether simvastatin reduces lung injury caused by ischaemia-reperfusion of the hind limbs in rats. The control group underwent dissection of bilateral femoral arteries; another group (I/R group) underwent ischaemia of bilateral hind limbs for 2 h followed by 3 h reperfusion; and two other groups were pretreated with 5 or 10 mg/kg per day simvastatin for 3 days and then underwent ischaemia-reperfusion. The control and I/R group rats received placebo (water) instead of simvastatin. The lungs of the I/R rats showed marked histopathological changes compared with the other groups. Lung tissue myeloperoxidase, malondialdehyde, neutrophil count and lung injury scores in both simvastatin groups were significantly lower than in the I/R group; 10 mg/kg per day simvastatin significantly reduced lung water content although 5 mg/kg per day did not. Expression of haem oxygenase-1 (HO-1) protein in lung tissue was significantly greater in the simvastatin groups than in the I/R group. Simvastatin protects against lung injury associated with lower extremity ischaemia-reperfusion by reduction of neutrophil aggregation and oxidative damage, and upregulation of HO-1 expression in the injured lung.

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Antioxidant effects of simvastatin in primary and secondary prevention of coronary heart disease

Abstract: This study demonstrates that simvastatin can significantly reduce circulating ox-LDL levels both in subjects undergoing primary and secondary prevention of CHD. These results could partly explain the slowing down of the progression of atherosclerosis caused by HMG-CoA reductase inhibitors.

Cited by 23 publications

References 22 publications

Effects of Campomanesia xanthocarpa on biochemical, hematological and oxidative stress parameters in hypercholesterolemic patients

Effects of Campomanesia xanthocarpa on biochemical, hematological and oxidative stress parameters in hypercholesterolemic patients

Ezetimibe's effect on platelet aggregation and LDL tendency to peroxidation in hypercholesterolaemia as monotherapy or in addition to simvastatin

Effects of Simvastatin on Lung Injury Induced by Ischaemia–Reperfusion of the Hind Limbs in Rats

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