2019
DOI: 10.1016/j.fct.2019.03.050
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Antioxidant effects of sulforaphane in human HepG2 cells and immortalised hepatocytes

Abstract: Sulforaphane (SFN) has shown anti-cancer effects in cellular and animal studies but its effectiveness has been limited in human studies. Here, the effects of SFN were measured in both human hepatocyte (HHL5) and hepatoma (HepG2) cells. Results showed that SFN inhibited cell viability and induced DNA strand breaks at high doses (≥ 20 µM). It also activated the nuclear factor (erythroidderived 2)-like 2 (Nrf2), and increased intracellular glutathione (GSH) levels at 24 hours. Pretreatment with a low dose SFN (≤5… Show more

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Cited by 27 publications
(20 citation statements)
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“…These findings provided a strong rationale for evaluating the protective effects of a broccoli sprout preparation, claiming sulforaphane as a good candidate in the adjuvant therapy based on natural molecules against several types of cancer [127]. However, some studies indicate that this compound might exert pro-survival effects in cancer cells [128] and potentially interfere with the successful application of immunotherapy [129]. Table 2 contains some of the studies conducted in this field.…”
Section: Potential Use Of Nrf2 Activators In Cancer Therapymentioning
confidence: 99%
“…These findings provided a strong rationale for evaluating the protective effects of a broccoli sprout preparation, claiming sulforaphane as a good candidate in the adjuvant therapy based on natural molecules against several types of cancer [127]. However, some studies indicate that this compound might exert pro-survival effects in cancer cells [128] and potentially interfere with the successful application of immunotherapy [129]. Table 2 contains some of the studies conducted in this field.…”
Section: Potential Use Of Nrf2 Activators In Cancer Therapymentioning
confidence: 99%
“…A chemopreventive agent should have strong inhibitory effect on cell proliferation and carcinogenic pathways of cancer cells however, minimal effect on healthy cells. For the treatment of cancer, the natural therapies by plant extracts may reduce the side effects and toxic effects of therapies (Liu, Wang, Tang, Bowater, & Bao, 2019;Ramadan et al, 2017). However, HepG2 cancer cells were less sensitive to VPR extracts than CCD 841 CoN cells.…”
Section: Anticancer Activity Of Vpr Extractsmentioning
confidence: 99%
“…However, HepG2 cancer cells were less sensitive to VPR extracts than CCD 841 CoN cells. This may be explained by the fact that HepG2 cells retain many of the specialized function of normal hepatocytes (Liu et al, 2019).…”
Section: Anticancer Activity Of Vpr Extractsmentioning
confidence: 99%
“…It is expected to get a better understanding of LD metabolism that clarification of the detailed interaction among the oxidation of LDs, ROS, ER stress, and mitochondrial function. For another limitation, the result with primary cells might be different from those with the cultured tumor cells, 46 .c…”
Section: Evaluation Of the Effects Of Food-derived Antioxidants On Ldmentioning
confidence: 99%