Antioxidant efficacy of vitamins loaded lipid based delivery systems with different microstructure for dermal application

Vitek, M.; Matjaž, Mirjam Gosenca; Gašperlin, Mirjana; Roškar, Robert; Pobirk, Alenka Zvonar

doi:10.14232/syrptbrs.2021.op34

Cited by 1 publication

(3 citation statements)

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“…Moreover, topical application of lipids may also be beneficial in terms of repairing the deficient lipid composition of atopic skin. In addition, structural characterization using polarized light microscopy and small-angle light scattering showed the predominant presence of tightly packed lamellae in these LCCs (24,25). Notably, the lamellar microstructure of formulations for dermal application is extremely beneficial due to its great similarity with the SC lipids.…”

Section: Resultsmentioning

confidence: 99%

“…The study was a double-blind, interventional, before-after, single-group study. Eight LCCs were prepared as previously described (23). Due to our interest in the evaluation of the LCCs' influence on skin barrier function, only unloaded LCCs were tested.…”

Section: Methodsmentioning

confidence: 99%

“…Innovative lamellar lyotropic liquid crystals (LCCs), based on hempseed or flaxseed oil and loaded with betamethasone dipropionate drug for potential AD treatment were developed by our research group (23)(24)(25). The composition of the novel LCCs was primarily driven by the objective of formulating an advanced delivery system for dermal application with skin-compliant and barrier-strengthening characteristics.…”

Section: Introductionmentioning

confidence: 99%

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Clinical application of hempseed or flaxseed oil-based lyotropic liquid crystals: Evaluation of their impact on skin barrier function

Vitek,

Matjaž

2024

Acta Pharmaceutica

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The principal function of skin is to form an effective barrier between the human body and its environment. Impaired barrier function represents a precondition for the development of skin diseases such as atopic dermatitis (AD), which is the most common inflammatory skin disease characterized by skin barrier dysfunction. AD significantly affects patients’ quality of life, thus, there is a growing interest in the development of novel delivery systems that would improve therapeutic outcomes. Herein, eight novel lyotropic liquid crystals (LCCs) were investigated for the first time in a double-blind, interventional, before-after, single-group trial with healthy adult subjects and a twice-daily application regimen. LCCs consisted of constituents with skin regenerative properties and exhibited lamellar micro-structure, especially suitable for dermal application. The short- and long-term effects of LCCs on TEWL, SC hydration, erythema index, melanin index, and tolerability were determined and compared with baseline. LCCs with the highest oil content and lecithin/Tween 80 mixture stood out by providing a remarkable 2-fold reduction in TEWL values and showing the most distinctive decrease in skin erythema levels in both the short- and long-term exposure. Therefore, they exhibit great potential for clinical use as novel delivery systems for AD treatment, capable of repairing skin barrier function.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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