Antioxidant efficiency of Beech (Fagus sylvatica L.) bark polyphenols assessed by chemometric methods

Hofmann, Thilo; Tálos-Nebehaj, Esztella; Albert, Levente; Németh, László

doi:10.1016/j.indcrop.2017.06.016

Cited by 21 publications

(16 citation statements)

References 25 publications

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“…It was observed that during the process of microwave extraction, time and microwave power are the main factors that influence efficiency significantly. It has also been noticed that the combination of miscible polar solvents improves the extraction yield [22,26,38,39].…”

Section: Methods Used To Extract Phenolic Compounds From the Bark mentioning

confidence: 99%

“…For example, Hofmann et al [25] studied beech ( Fagus sylvatica L., Fagaceae) bark and determined that the total polyphenol content was approximately 57 mg gallic acid (GAE)/g dry bark units. The most efficient compounds with potential antioxidant activity in beech bark are epicatechin, coumaric acid, coniferin, quercetin, taxifolin- O -hexoside, coumaric acid-di- O -hexoside, syringic acid-di- O -hexoside, coniferyl alcohol- O -hexoside [26].…”

Section: The Bark Of Woody Vascular Plants—source Of Phenolic Compmentioning

confidence: 99%

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A Critical Review of Phenolic Compounds Extracted from the Bark of Woody Vascular Plants and Their Potential Biological Activity

2019

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Polyphenols are one of the largest and most widespread groups of secondary metabolites in the plants world. These compounds are of particular interest due to their occurrence and the properties they possess. The main sources of phenolic compounds are fruits and vegetables, but lately, more and more studies refer to woody vascular plants, especially to bark, as an important source of phenolic compounds with a potential biological effect. This study aims to bring together information on the phenolic compounds present in the bark of woody vascular plants by discussing extraction methods, the chemical composition of the extracts and potential biological effects. The literature data used in this paper were collected via PubMed (2004–2019). Search terms were: bark, rhytidome, woody vascular plant, polyphenols, phenolic compounds, biologic activity, antioxidant, immunostimulatory, antimutagenic, antibacterial, anti-inflammatory, and antitumoral. This paper intends to highlight the fact that the polyphenolic extracts obtained from the bark of woody vascular plants represent sources of bioactive compounds with antioxidant, immunostimulatory, antimutagenic, antibacterial properties, etc. Future research directions should be directed towards identification and isolation of bioactive compounds. Consequently, biologically active compounds obtained from the bark of woody plants could be exploited on an industrial scale.

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Section: Methods Used To Extract Phenolic Compounds From the Bark mentioning

confidence: 99%

Section: The Bark Of Woody Vascular Plants—source Of Phenolic Compmentioning

confidence: 99%

A Critical Review of Phenolic Compounds Extracted from the Bark of Woody Vascular Plants and Their Potential Biological Activity

2019

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“…Some literature data highlights that beech bark can be a rich source of bioactive compounds [10,11]. Furthermore, in a previous study some of the phenolic compounds obtained from beech bark by hot water extraction were identified (vanillic acid, catechin, taxifolin and syringin) [11,12].…”

Section: Introductionmentioning

confidence: 99%

Biological and Chemical Insights of Beech (Fagus sylvatica L.) Bark: A Source of Bioactive Compounds with Functional Properties

et al. 2019

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The present study aimed, on the one hand, to improve the yield of microwave assisted extraction (MAE) of polyphenols from beech bark by using a design of experiments (DoE) approach. On the other hand, beech bark extracts (BBE) were characterized in terms of their phytochemical profile and evaluated for biological potential (antioxidant, antibacterial, antifungal, antimutagen, anti-α-glucosidase, and anti-tyrosinase). The extraction time varies with the amount of extracted total phenolic content (TPC). The microwave power favors TPC extraction but in different proportions. The optimum conditions which gave the highest TPC (76.57 mg GAE/g dry plant material) were reached when the microwave power was 300 W, extraction time was 4 min, and the solvent was an ethanol–water (50:50) mixture. The practical value of TPC after a controlled experiment was 76.49 mg GAE/g plant material. The identified compounds were vanillic acid, gallic acid, epicatechin, catechin, protocatechuic acid, chlorogenic acid, ferulic acid, and isoquercitrin. The antioxidant potential of BBEs was demonstrated by in vitro experiments. The BBEs were active against Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella typhimurium, Escherichia coli, and Candida species. All extracts were antimutagenic and expressed an inhibition on α-glucosidase and tyrosinase activity. Regarding antimutagen activity, the assayed extracts may be considered to have low or no antimutagen effects.

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“…Similarly, peak 9 was identified as 3- O -di-glucosyl-4-methoxybenzoic acid (C 20 H 27 O 14 − ) and peak 12 was identified as the derivative 4- O -(3- O -glucosyl-4-hydroxybenzoyl)-quinic acid (C 20 H 25 O 14 − ). Peak 14 with an ion at m / z : 475.14571 was identified as 4-methoxybenzoic acid 3- O -rutinoside (C 20 H 27 O 13 − ) and peak 16 with an ion at m / z : 359.09872 was identified as syringic acid hexose (C 15 H 19 O 10 − ) [20]. Finally, peaks 17 and 21 were identified as caffeic and coumaric acids, respectively.…”

Section: Resultsmentioning

confidence: 99%

Mulinum crassifolium Phil; Two New Mulinanes, Gastroprotective Activity and Metabolomic Analysis by UHPLC-Orbitrap Mass Spectrometry

et al. 2019

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Mulinum crassifolium Phil. (Apiaceae) is an endemic shrub from Chile commonly used as infusion in traditional medicine to treat diabetes, bronchial and intestinal disorders and stomach ailments, including ulcers. From the EtOAc extract of this plant, the new mulinane-type diterpenoids 3 and 5 were isolated along with three known diterpenoids. The gastroprotective effect of the infusion of the plant was assayed to support the traditional use and a fast HPLC analysis using high resolution techniques was performed to identify the bioactive constituents. The EtOAc extract and the edible infusion showed gastroprotective effect at 100 mg/kg in the HCl/EtOH induced gastric ulcer model in mice, reducing lesions by 33% and 74%, respectively. Finally, a metabolomic profiling based on UHPLC-ESI-MS/HRMS of the edible infusion was performed and thirty-five compounds were tentatively identified including quercetin, caffeic acid, apigenine glucoside, p-coumaric acid, chlorogenic acids, and caffeoylquinic acids, which have been associated previously with gastroprotective and antiulcer properties. This scientific evidence can support the contribution of polyphenols in the gastroprotective activity of the edible infusion of this plant, and can validate at least in part, its ethnopharmacological use.

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Antioxidant efficiency of Beech (Fagus sylvatica L.) bark polyphenols assessed by chemometric methods

Cited by 21 publications

References 25 publications

A Critical Review of Phenolic Compounds Extracted from the Bark of Woody Vascular Plants and Their Potential Biological Activity

A Critical Review of Phenolic Compounds Extracted from the Bark of Woody Vascular Plants and Their Potential Biological Activity

Biological and Chemical Insights of Beech (Fagus sylvatica L.) Bark: A Source of Bioactive Compounds with Functional Properties

Mulinum crassifolium Phil; Two New Mulinanes, Gastroprotective Activity and Metabolomic Analysis by UHPLC-Orbitrap Mass Spectrometry

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