Antioxidant enzyme levels in cases with gastrointesinal cancer

Kekeç, Yalçın; Paydaş, Semra; Tuli, Abdullah; Zorludemir, Suzan; Sakman, Gürhan; Seydaoğlu, Gülşah

doi:10.1016/j.ejim.2008.12.003

Cited by 42 publications

(24 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Yalcin Kekec et al have demonstrated that G6PD activity was higher in gastric cancer tissues compared to paired normal tissues and was found to be related with malignant phenotype in gastrointestinal cancers [20]. Our study further confirmed the close relationship between G6PD and gastric cancer in the protein and mRNA levels.…”

Section: Discussionsupporting

confidence: 92%

Overexpression of G6PD is associated with poor clinical outcome in gastric cancer

et al. 2011

View full text Add to dashboard Cite

This study aims to investigate the expression and significance of glucose-6-phosphate dehydrogenase (G6PD) in human gastric cancer progression and prognosis. Using immunohistochemistry and real-time RT-PCR assay, we identified abnormally elevated expression of G6PD in gastric cancer tissues compared to paired normal stomach mucosa tissues in 24 patients (p < 0.05). In order to investigate the correlations between G6PD and the clinicopathological features of gastric cancer, the expression of G6PD in 167 patients with gastric cancer were detected by immunohistochemistry, and the results showed that overexpression of G6PD was associated with the size of tumor (p = 0.039), depth of invasion (p = 0.039), lymph node metastasis (p = 0.044), distant metastasis (p = 0.003), TNM stage (p = 0.030), and survival rate (p = 0.010). Further, Cox multivariates analysis indicated that G6PD expression level was an independent prognostic factor for patients after radical resection (p = 0.013). In conclusion, overexpression of G6PD is closely related to progression of gastric cancer, and might be regarded as an independent predictor of poor prognosis for gastric cancer.

show abstract

Section: Discussionsupporting

confidence: 92%

Overexpression of G6PD is associated with poor clinical outcome in gastric cancer

et al. 2011

View full text Add to dashboard Cite

show abstract

“…The production of peroxides and free radicals associated with changes in the normal redox state of tissues can induce toxic effects including oxidative DNA damage that along with hypoxia, and acidosis, might be greatly involved in the pathogenesis of GC as it can be considered the cause as well as the consequence of tumor progression [29,30]. Some evidence showed a wide magnitude of oxidative stress in GC cases if compared with healthy individuals, as demonstrated by elevated levels of lipid peroxidation products and depletion of enzymatic and non-enzymatic antioxidants [31,32]. In view of all these findings, the results of our study, which reports a protective effect of the apoE ε2 allele on GC, might be explained by the improved antioxidant properties of ε2 allele compared with the ε3 or ε4 alleles, and this evidence can be especially true for GC, whose pathogenesis is strongly affected by smoking-related oxidative stress [33].…”

Section: Discussionmentioning

confidence: 99%

A case–control study on the effect of Apolipoprotein E genotypes on gastric cancer risk and progression

et al. 2012

View full text Add to dashboard Cite

BackgroundApolipoprotein E (ApoE) is a multifunctional protein playing both a key role in the metabolism of cholesterol and triglycerides, and in tissue repair and inflammation. The ApoE gene (19q13.2) has three major isoforms encoded by ε2, ε3 and ε4 alleles with the ε4 allele associated with hypercholesterolemia and the ε2 allele with the opposite effect. An inverse relationship between cholesterol levels and gastric cancer (GC) has been previously reported, although the relationship between apoE genotypes and GC has not been explored so far.MethodsOne hundred and fifty-six gastric cancer cases and 444 hospital controls were genotyped for apoE polymorphism (ε2, ε3, ε4 alleles). The relationship between GC and putative risk factors was measured using the adjusted odds ratios (ORs) and their 95% confidence intervals (CIs) from logistic regression analysis. A gene-environment interaction analysis was performed. The effect of the apoE genotypes on survival from GC was explored by a Kaplan–Meier analysis and Cox proportional hazard regression model.ResultsSubjects carrying at least one apoE ε2 allele have a significant 60% decrease of GC risk (OR=0.40, 95% CI: 0.19 – 0.84) compared with ε3 homozygotes. No significant interaction emerged between the ε4 or ε2 allele and environmental exposures, nor ε2 or ε4 alleles affected the median survival times, even after correcting for age, gender and stadium.ConclusionsOur study reports for the first time a protective effect of the ε2 allele against GC, that might be partly attributed to the higher antioxidant properties of ε2 compared with the ε3 or ε4 alleles. Given the study’s sample size, further studies are required to confirm our findings.

show abstract

“…In this study, delayed formation and reduced growth of tumor cells in nude mice injected with A375-G6PD-deficient cells were also demonstrated (45). In gastric cancer, Kekec et al demonstrated that G6PD activity was higher in tumoral tissue than in normal one (46). Moreover, Wang et al observed that G6PD overexpression in this tumor type positively correlated with different clinicopathological features analyzed, such as tumor size, invasion, metastasis, and survival (47).…”

Section: Glucose-6-phosphate Dehydrogenasementioning

confidence: 99%

Emerging Role of the Pentose Phosphate Pathway in Hepatocellular Carcinoma

2017

View full text Add to dashboard Cite

In recent years, there has been a revival of interest in metabolic changes of cancer cells as it has been noticed that malignant transformation and metabolic reprogramming are closely intertwined. The pentose phosphate pathway (PPP) is one of the fundamental components of cellular metabolism crucial for cancer cells. This review will discuss recent findings regarding the involvement of PPP enzymes in several types of cancer, with a focus on hepatocellular carcinoma (HCC). We will pay considerable attention to the involvement of glucose-6-phosphate dehydrogenase, the rate-limiting enzyme of the PPP. Subsequently, we discuss the inhibition of the PPP as a potential therapeutic strategy against cancer, in particular, HCC.

show abstract

Antioxidant enzyme levels in cases with gastrointesinal cancer

Cited by 42 publications

References 19 publications

Overexpression of G6PD is associated with poor clinical outcome in gastric cancer

Overexpression of G6PD is associated with poor clinical outcome in gastric cancer

A case–control study on the effect of Apolipoprotein E genotypes on gastric cancer risk and progression

Emerging Role of the Pentose Phosphate Pathway in Hepatocellular Carcinoma

Contact Info

Product

Resources

About