Antioxidant enzymes and lipid peroxidation in different forms of schizophrenia treated with typical and atypical antipsychotics

Zhang, Xiang Yang; Tan, Yun Long; Cao, Lian Yuan; Wu, Gui Ying; Xu, Qi; Shen, Yan; Zhou, Dong

doi:10.1016/j.schres.2005.10.011

Cited by 241 publications

(154 citation statements)

References 39 publications

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“…On the other hand, previous (Zhang et al, 2006) and present studies all revealed that the plasma total antioxidant status decreases in schizophrenia. Though the results are not completely identical, it mainly presents on three critical antioxidant enzymes SOD, CAT and GSH-Px; a possible explanation may be different subtype or drug effects.…”

Section: Discussioncontrasting

confidence: 52%

“…Antioxidant defense status changes accordingly (Herken et al, 2001a;Yao et al, 1998a). Superoxide dismutase (SOD), a key enzyme involved in the detoxification of superoxide radicals, has been consistently found increased (Vaiva et al, 1994;Yao et al, 1998b;Zhang et al, 2003a) in drug-free patients or those with TD (tardive dyskinesia) (Yao et al, 1998b;Zhang et al, 2003a), unchanged (Herken et al, 2001a) or decreased (Zhang et al, 2006) (Yao et al, 1998b) while unchanged (Yao et al, 1999) or decreased (Zhang et al, 2006) in chronic patients. Other antioxidant enzyme activity such as catalase (CAT) increased (Herken et al, 2001a) in different form of schizophrenia.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, some indices are related to severity of psychosis (Vaiva et al, 1994;Yao et al, 1999;Zhang et al, 2003a) or age (Yao et al, 2000b). Some studies (Taneli et al, 2004;Yao et al, 1998a;1998b;1999;2000b;Zhang et al, 2006) indicated that antipsychotic drugs have no significant regulatory action on the antioxidative defense system. However, more studies revealed that antioxidant enzyme activities are associated with the treatment of schizophrenic patients with different neuroleptics Pillai et al, 2006;Reddy et al, 2003;Vaiva et al, 1994;Yao et al, 1998b;Zhang et al, 2001a;2003b).…”

Section: Introductionmentioning

confidence: 99%

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Imbalanced free radicals and antioxidant defense systems in schizophrenia: A comparative study

Chen

et al. 2006

J. Zhejiang Univ. - Sci. B

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Abstract:Objective: To examine changes of blood oxidative-antiovidative level in schizophrenic patients and its relationship with clinical symptoms. Methods: Forty-six Chinese patients met DSM-IV (Diagnostic and Statistical Manual of Mental Disorders-IV) criteria for schizophrenia and fifty age-and sex-matched healthy controls were enrolled in the present study. Baseline psychiatric symptom severity was assessed with brief psychiatric rating scale, positive and negative syndrome scale on the blood draw day. Fresh blood samples were collected to measure levels of nitric oxide and lipid peroxide in plasma as well as activities of superoxide dismutase, catalase and glutathione peroxidase in red blood cells by spectrophotometric assays simultaneously. Results: Comparison of the biochemical parameters indicated that the level of nitric oxide and lipid peroxide increased in patient group, which represented a positive correlation with positive scale scores; while the activities of three critical enzymes decreased and showed a negative linear correlation. Conclusion: This study showed that there are dysregulation of free radical metabolism and poor activities of the antioxidant defense systems in schizophrenic patients. Excess free radicals formation may play a critical role in the etiology of schizophrenia. Using antioxidants might be an effective therapeutic approach to partially alleviate or prevent the symptoms of schizophrenia.

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Section: Discussioncontrasting

confidence: 52%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Imbalanced free radicals and antioxidant defense systems in schizophrenia: A comparative study

Chen

et al. 2006

J. Zhejiang Univ. - Sci. B

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“…Furthermore, there is mounting evidence implicating mitochondrial defects and the resulting oxidative stress in the pathogenesis of schizophrenia (Altar et al, 2005;Herken et al, 2001;Mahadik and Mukherjee, 1996;Marchbanks et al, 2003;Prabakaran et al, 2004). Schizophrenic patients display a number of biomarkers indicative of increased oxidative stress, such as reduced GSH levels (Do et al, 2000), increased malondialdehyde levels (Zhang et al, 2006(Zhang et al, , 2007, and altered antioxidant enzyme activities (Gysin et al, 2007;Zhang et al, 2006). We observed an upregulation of the GSTM1 in both G72Tg mouse lines and additional an increased expression of the GSTP1 in G72Tg1 mice.…”

Section: Discussionmentioning

confidence: 58%

N-acetyl Cysteine Treatment Rescues Cognitive Deficits Induced by Mitochondrial Dysfunction in G72/G30 Transgenic Mice

Otte

Sommersberg

Kudin

et al. 2011

Neuropsychopharmacol

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Genetic studies have implicated the evolutionary novel, anthropoid primate-specific gene locus G72/G30 in psychiatric diseases. This gene encodes the protein LG72 that has been discussed to function as a putative activator of the peroxisomal enzyme D-aminoacid-oxidase (DAO) and as a mitochondrial protein. We recently generated 'humanized' bacterial artificial chromosome transgenic mice (G72Tg) expressing G72 transcripts in cells throughout the brain. These mice exhibit several behavioral phenotypes related to psychiatric diseases. Here we show that G72Tg mice have a reduced activity of mitochondrial complex I, with a concomitantly increased production of reactive oxygen species. Affected neurons display deficits in short-term plasticity and an impaired capability to sustain synaptic activity. These deficits lead to an impairment in spatial memory, which can be rescued by pharmacological treatment with the glutathione precursor N-acetyl cysteine. Our results implicate LG72-induced mitochondrial and synaptic defects as a possible pathomechanism of psychiatric disorders.

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“…Studies examining the oxidative metabolism in patients with schizophrenia established that TOS level and OSI values and other oxidant parameters were signifi cantly higher in patients with schizophrenia than those in controls (17)(18)(19)(20). Although there are studies generally demonstrating increase of oxidants in patients with schizophrenia, a few have shown that there was no change (21,22).…”

Section: Discussionmentioning

confidence: 99%

Elevated nucleosome level and oxidative stress in schizophrenia patients

Bahçeci¹,

Mh²,

Us³

et al. 2015

BLL

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AIM: The aim of this study was to investigate the effect of oxidative stress on nucleosome levels and its relation with the clinical features in schizophrenia patients. MATERIAL AND METHOD: Thirty schizophrenia patients and 30 healthy controls were enrolled in this study. Patients were diagnosed with schizophrenia according to the 4th edition of the Diagnostic and Statistical Manual for Mental Disorders (DSM-IV). The control group consisted of 30 healthy subjects matched to the patients with regard to age and gender and who had no history of any psychiatric disorder. The severity of schizophrenia symptoms in the patients was evaluated using the Positive and Negative Syndrome Scale (PANSS) and the Clinical Global Impression Severity Scale (CGI-S). Physical and neurological examinations were performed in each of the patients and controls. RESULTS: Nucleosome, total oxidant levels and OSI values were higher in schizophrenia patients than in controls (p < 0.05). There was no signifi cant difference in the total antioxidant levels. There was a positive correlation between the nucleosome level and PANSS positive subscale (p = 0.028, r = 0.402). There was a positive correlation between TAS and age (p = 0.025, r = 0.289), PANSS total (p < 0.001, r = 0.604). There was a negative correlation between OSI and PANSS total (p = 0.019, r = -0.427), PANSS positive subscale (p = 0.043, r = -0.372). There was a negative correlation between TOS and PANS total (p = 0.028, r = -0.402). CONCLUSION: In this study we found a correlation between nucleosome level and PANSS positive subscale. To our knowledge, this is the fi rst study that evaluates oxidative stress and nucleosomes released from apoptotic cells together (Tab. 2, Ref. 50). Text in PDF www.elis.sk.

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Antioxidant enzymes and lipid peroxidation in different forms of schizophrenia treated with typical and atypical antipsychotics

Cited by 241 publications

References 39 publications

Imbalanced free radicals and antioxidant defense systems in schizophrenia: A comparative study

Imbalanced free radicals and antioxidant defense systems in schizophrenia: A comparative study

N-acetyl Cysteine Treatment Rescues Cognitive Deficits Induced by Mitochondrial Dysfunction in G72/G30 Transgenic Mice

Elevated nucleosome level and oxidative stress in schizophrenia patients

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