Antioxidant Enzymes Haplotypes and Polymorphisms Associated with Obesity in Mexican Children

Costa-Urrutia, Paula; Flores-Buendía, Aline Mariana; Ascencio-Montiel, Iván de Jesús; Solares-Tlapechco, Jacqueline; Medina-Campos, Omar Noel; Pedraza‐Chaverrí, José; Granados, Julio; Jiménez-Osorio, Angélica Saraí; Rodríguez-Arellano, Martha Eunice

doi:10.3390/antiox9080684

Cited by 9 publications

(4 citation statements)

References 37 publications

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“…Also, when MDA is concerned discrepant results were reported between studies. Higher serum MDA levels were shown in some studies [26] [27] [28] [29] [30] , whereas no difference between study groups was found in the others [31] [32] [33] [34] [35] [36] .…”

Section: Discussionmentioning

confidence: 84%

Malondialdehyde as an independent predictor of body mass index in adolescent girls

Klisić¹,

Malenica²,

Kostadinovic³

et al. 2023

J Med Biochemistry

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Objective: Given the fact that the studies that examined oxidative stress in relation to obesity that included late adolescents are scarce and show inconclusive results we aimed to investigate a wide spectrum of nitro-oxidative stress biomarkers [i.e., malondialdehyde (MDA), xanthine oxidase (XO), xanthine oxidoreductase (XOD), xanthine dehydrogenase (XDH), advanced oxidation protein products (AOPP) and nitric oxide products (NOx), as well as an antioxidative enzyme, i.e., catalase (CAT)] in relation with obesity in the cohort of adolescent girls ages between 16 and 19 years old.Patients and Methods: A total of 59 teenage girls were included in this cross-sectional study. Binary logistic regression analysis was performed to examine possible associations between biochemical and nitro-oxidative stress markers and body mass index (BMI). Results: There were not significant differences between oxidative stress markers between normal weight and overweight/obese girls (i.e., AOPP, XOD, XO, XDH) and CAT, except for MDA (p<0.001) and NOx (p=0.010) concentrations which were significantly higher in overweight/obese adolescent girls. Positive associations were evident between BMI and high sensitivity C-reactive protein (hsCRP) (OR=2.495), BMI and uric acid (OR=1.024) and BMI and MDA (OR=1.062). Multivariable binary regression analysis demonstrated significant independent associations of BMI and hsCRP (OR=2.150) and BMI and MDA (OR=1.105). Even 76.3% of the variation in BMI could be explained with this Model.Conclusion: Inflammation (as measured with hsCRP) and oxidative stress (as determined with MDA) independently correlated with BMI in teenage girls.

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Section: Discussionmentioning

confidence: 84%

Malondialdehyde as an independent predictor of body mass index in adolescent girls

Klisić¹,

Malenica²,

Kostadinovic³

et al. 2023

J Med Biochemistry

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“…For instance, GPX3 expression was found to be elevated in the serum of overweight and obese individuals in central Mexico, with serum GPX3 concentration positively correlating with body weight and inversely correlating with insulin sensitivity [ 137 ]. GPX3 rs922429 was shown to protect against obesity according to body fat percentage in a study in Mexico [ 138 ]. Conversely, other studies reported no significant differences in GPX3 serum concentrations between obese and lean individuals, although GPX3 expression in subcutaneous adipose tissue increased after weight loss and was greater in lean and insulin-sensitive individuals than in their obese and insulin-resistant counterparts [ 139 ].…”

Section: Research Progress In Gpx3 and Non-neoplastic Diseasesmentioning

confidence: 99%

Insights into the Role of Glutathione Peroxidase 3 in Non-Neoplastic Diseases

Zhang,

Liao,

Lin

et al. 2024

Biomolecules

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Reactive oxygen species (ROSs) are byproducts of normal cellular metabolism and play pivotal roles in various physiological processes. Disruptions in the balance between ROS levels and the body’s antioxidant defenses can lead to the development of numerous diseases. Glutathione peroxidase 3 (GPX3), a key component of the body’s antioxidant system, is an oxidoreductase enzyme. GPX3 mitigates oxidative damage by catalyzing the conversion of hydrogen peroxide into water. Beyond its antioxidant function, GPX3 is vital in regulating metabolism, modulating cell growth, inducing apoptosis and facilitating signal transduction. It also serves as a significant tumor suppressor in various cancers. Recent studies have revealed aberrant expression of GPX3 in several non-neoplastic diseases, associating it with multiple pathological processes. This review synthesizes the current understanding of GPX3 expression and regulation, highlighting its extensive roles in noncancerous diseases. Additionally, this paper evaluates the potential of GPX3 as a diagnostic biomarker and explores emerging therapeutic strategies targeting this enzyme, offering potential avenues for future clinical treatment of non-neoplastic conditions.

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“…As the only member of the glutathione peroxidase superfamily capable of neutralizing lipid peroxides, glutathione peroxidase-4 (GPx4) is a master regulator of ferroptosis and experimental studies have shown that this selenoenzyme has important pathophysiological roles in many cardiometabolic, neurodegenerative, autoimmune diseases and malignancies ( Park et al, 2019 ; Ursini et al, 2022 ; Wang et al, 2022 ; Xu et al, 2022 ). A large number of genetic epidemiological studies have linked gpx4 variants and GPx4 content/activity with obesity ( Rupérez et al, 2014 ; Costa-Urrutia et al, 2020 ) cardiovascular and inflammatory diseases ( Polonikov et al, 2012 ; Berdaweel et al, 2022 ), and cancer ( Méplan et al, 2010 ).…”

Section: Introductionmentioning

confidence: 99%

Iron scavenging and suppression of collagen cross-linking underlie antifibrotic effects of carnosine in the heart with obesity

Berdaweel,

Monroe,

Alowaisi

et al. 2024

Front. Pharmacol.

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Oral consumption of histidyl dipeptides such as l-carnosine has been suggested to promote cardiometabolic health, although therapeutic mechanisms remain incompletely understood. We recently reported that oral consumption of a carnosine analog suppressed markers of fibrosis in liver of obese mice, but whether antifibrotic effects of carnosine extend to the heart is not known, nor are the mechanisms by which carnosine is acting. Here, we investigated whether oral carnosine was able to mitigate the adverse cardiac remodeling associated with diet induced obesity in a mouse model of enhanced lipid peroxidation (i.e., glutathione peroxidase 4 deficient mice, GPx4+/−), a model which mimics many of the pathophysiological aspects of metabolic syndrome and T2 diabetes in humans. Wild-type (WT) and GPx4+/−male mice were randomly fed a standard (CNTL) or high fat high sucrose diet (HFHS) for 16 weeks. Seven weeks after starting the diet, a subset of the HFHS mice received carnosine (80 mM) in their drinking water for duration of the study. Carnosine treatment led to a moderate improvement in glycemic control in WT and GPx4+/−mice on HFHS diet, although insulin sensitivity was not significantly affected. Interestingly, while our transcriptomic analysis revealed that carnosine therapy had only modest impact on global gene expression in the heart, carnosine substantially upregulated cardiac GPx4 expression in both WT and GPx4+/−mice on HFHS diet. Carnosine also significantly reduced protein carbonyls and iron levels in myocardial tissue from both genotypes on HFHS diet. Importantly, we observed a robust antifibrotic effect of carnosine therapy in hearts from mice on HFHS diet, which further in vitro experiments suggest is due to carnosine’s ability to suppress collagen-cross-linking. Collectively, this study reveals antifibrotic potential of carnosine in the heart with obesity and illustrates key mechanisms by which it may be acting.

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Antioxidant Enzymes Haplotypes and Polymorphisms Associated with Obesity in Mexican Children

Cited by 9 publications

References 37 publications

Malondialdehyde as an independent predictor of body mass index in adolescent girls

Malondialdehyde as an independent predictor of body mass index in adolescent girls

Insights into the Role of Glutathione Peroxidase 3 in Non-Neoplastic Diseases

Iron scavenging and suppression of collagen cross-linking underlie antifibrotic effects of carnosine in the heart with obesity

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