Antioxidant extract counteracts the effects of aging on cortical spreading depression and oxidative stress in the brain cortex

Sousa, Mariana Séfora Bezerra; Holanda, Iasmym Melissa Soares de; Monteiro, Heloísa Mirelle Costa; Amâncio-dos-Santos, Ângela

doi:10.1590/s0102-865020180060000001

Cited by 12 publications

(8 citation statements)

References 26 publications

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“…GSH/GSSG is considered a key indicator of oxidative stress [56,57]. In particular, the increase in the ratio indicates a decrease in cellular oxidative stress [58][59][60]. As shown in Figure 5, we found that in LPS-treated THP1 M0 cells the pre-treatment for 2 h with Cfr-LEO induced the increase of the GSH/GSSG ratio compared to no pre-treated cells, indicating the ability of Cfr-LEO to counteract the LPS-induced oxidative stress.…”

Section: Protective Effects Of Cfr-leo On Lps-activated Macrophagesmentioning

confidence: 99%

Biological Properties of a Citral-Enriched Fraction of Citrus limon Essential Oil

Pucci

Raimondo

Zichittella

et al. 2020

Foods

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Lemon essential oil (LEO) is a well-known flavoring agent with versatile biological activities. In the present study, we have isolated and characterized four citral-enriched fractions of winter LEO. We reported that in murine and human macrophages the pre-treatment with a mix of these fractions (Cfr-LEO) reduces the expression of the pro-inflammatory cytokines TNF-α, IL-1β, and IL-6 induced by LPS. In addition, Cfr-LEO counteracts LPS-induced oxidative stress, as shown by the increase in the GSH/GSSG ratio in comparison to cells treated with LPS alone. Overall, the results reported here encourage the application of EO fractions, enriched in citral, in the nutraceutical industry, not only for its organoleptic properties but also for its protective action against inflammation and oxidative stress.

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Section: Protective Effects Of Cfr-leo On Lps-activated Macrophagesmentioning

confidence: 99%

Biological Properties of a Citral-Enriched Fraction of Citrus limon Essential Oil

Pucci

Raimondo

Zichittella

et al. 2020

Foods

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“…In this review, we revisit the theme of the influence of aging on electrophysiological aspects of brain signaling as indexed by the excitability-related phenomenon known as cortical spreading depression (CSD; Guedes et al, 1996; Farkas et al, 2011; Sousa et al, 2018). In addition, we examine how aging interacts with other factors, such as alcohol consumption (Abadie-Guedes et al, 2016), physical exercise, and nutritional status (Batista-de-Oliveira et al, 2012; Silva-Gondim et al, 2017), regarding the brain’s capability of generating and propagating CSD, which has been continuously investigated in our laboratory for many years (see Guedes, 2005, 2011; Abadie-Guedes et al, 2016, for an overview).…”

Section: Introduction: Aging and Brain Functionmentioning

confidence: 99%

Brain Aging and Electrophysiological Signaling: Revisiting the Spreading Depression Model

Guedes

Abadie-Guedes

2019

Front. Aging Neurosci.

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As a consequence of worldwide improvement in health care, the aging portion of the human population has increased, now representing a higher proportion of the total population. This fact raises great concern regarding how to age while maintaining good brain function. Very often, alterations in brain electrophysiological signaling are associated with age-dependent functional disorders of the brain. Therefore, animal models suitable for the study of age-related changes in electrical activity of the brain can be very useful. Herein, we review changes in brain electrophysiological features as a function of age by analyzing studies in the rat brain on the phenomenon known as cortical spreading depression (CSD). Alterations in the brain’s capability to generate and propagate CSD may be related to differences in the propensity to develop certain neurological diseases, such as epilepsy, stroke, and migraine, which can biunivocally interact with the aging process. In this review, we revisit ours and others’ previous studies on electrophysiological features of the CSD phenomenon, such as its velocity of propagation and amplitude and duration of its slow negative DC shift, as a function of the animal age, as well as the interaction between age and other factors, such as ethanol consumption, physical exercise, and nutritional status. In addition, we discuss one relatively new feature through which CSD modulates brain signaling: the ability to potentiate the brain’s spontaneous electrical activity. We conclude that the CSD model might importantly contribute to a better understanding of the aging/brain signaling relationship.

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“…Mitochondria isolated from aged rat cortex and hippocampus showed increased ROS production compared to young rats, which was not observed in mitochondria isolated from the cerebellum (8). Aging also decreased glutathione/oxidized glutathione ratio and increased lipid peroxidation levels and superoxide dismutase activity in cerebral cortex of 24-month-old Wistar rats compared to 3-month-old rats (9). Also, aging increased lipid peroxides and lipid hydroperoxides but decreased SOD activity in the cerebrum, cerebellum, and brainstem of 6-, 13-, 19-, and 26-month-old male albino rats compared to 3-month-old rats (10).…”

Section: Introductionmentioning

confidence: 74%

Aging and low-intensity exercise change oxidative biomarkers in brain regions and radiographic measures of femur of Wistar rats

Silveira

Santos

Silva

et al. 2020

Braz J Med Biol Res

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Antioxidant extract counteracts the effects of aging on cortical spreading depression and oxidative stress in the brain cortex

Abstract: Murici extract supplementation seems to revert detrimental effects in aged brains and could be considered as a strategy in the treatment of pathologies related to aging and cortical spreading depression.

Cited by 12 publications

References 26 publications

Biological Properties of a Citral-Enriched Fraction of Citrus limon Essential Oil

Biological Properties of a Citral-Enriched Fraction of Citrus limon Essential Oil

Brain Aging and Electrophysiological Signaling: Revisiting the Spreading Depression Model

Aging and low-intensity exercise change oxidative biomarkers in brain regions and radiographic measures of femur of Wistar rats

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