Antioxidant farnesylated hydroquinones from Ganoderma capense

Peng, Xing‐Rong; Lei, Li; Wang, Xia; Zhu, Guo-Lei; Li, Zhongrong; Qiu, Ming‐Hua

doi:10.1016/j.fitote.2016.04.006

Cited by 31 publications

(41 citation statements)

References 33 publications

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“…The molecular formula of testing active compound C18 and the negative control compound C12 were determined by HRESIMS and 13 C-DEPT NMR at Kunming Institute of Botany, China, as previously described (Peng et al, 2016). These compounds were analysis by HPLC and determined to have a purity ≥ 95% ( Supplementary Figure 2).…”

Section: Compounds Preparationmentioning

confidence: 99%

“…The initial screening revealed that among these 6 compounds, cochlearin H (C9) , chizhine D (C10) (Luo et al, 2015), C30 (unpublished), and especially ganomycin F (C18) (Peng et al, 2016) Figure 3A). Meanwhile, C18 also has distinct inhibition on WKYMVm-induced cell degranulation in dHL60 cells (Supplementary Figure 3B).…”

Section: Screening the Active Components Of Ganoderma For Inhibitory mentioning

confidence: 99%

“…As a new compound of Ganoderma meroterpenoids (GMs), C18 was firstly isolated in 2016, and the molecular formula was determined as C 21 H 30 O 3 by HRESIMS and 13 C-DEPT NMR (Peng et al, 2016). Although the chemical properties have been determined, its biological activities remain unclear.…”

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confidence: 99%

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A Ganoderma-Derived Compound Exerts Inhibitory Effect Through Formyl Peptide Receptor 2

Wang

Peng

et al. 2020

Front. Pharmacol.

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Formyl peptide receptors (FPRs) are G protein-coupled receptors (GPCRs) widely expressed in neutrophils and other phagocytes. FPRs play important roles in host defense, inflammation, and the pathogenesis of infectious and inflammatory diseases. Because of these functions, FPRs are potential targets for anti-inflammatory therapies. In order to search for potentially novel anti-inflammatory agents, we examined Ganoderma (Lingzhi), a Chinese medicinal herbs known for its anti-inflammatory effects, and found that compound 18 (C18) derived from Ganoderma cochlear could limit the inflammatory response through FPR-related signaling pathways. Further studies showed that C18 could bind to FPR2 and induce conformation change of the receptor that differed from the conformational change induced by the pan-agonist, WKYMVm. C18 inhibited at the receptor level and blocked WKYMVm signaling through FPR2, resulting in reduced superoxide production and compromised cell chemotaxis. These results identified for the first time that a Ganoderma-derived component with inhibitory effects that acts through a G protein-coupled receptor FPR2. Considering its less than optimal IC 50 value, further optimization of C18 would be necessary for future applications.

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Section: Compounds Preparationmentioning

confidence: 99%

Section: Screening the Active Components Of Ganoderma For Inhibitory mentioning

confidence: 99%

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A Ganoderma-Derived Compound Exerts Inhibitory Effect Through Formyl Peptide Receptor 2

Wang

Peng

et al. 2020

Front. Pharmacol.

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“…1 , Table 1 ). Thus, compounds 1 – 6 , and 9–13 had a ketone carbonyl at C-1′ and a carboxyl or methyl ester at C-10′ or C-14′ [ 15 , 16 , 30 – 35 ]. Among them, compounds 2 and 13 existed positional isomerization of olefinic bond because of the shift of the double bond at C-2′ and C-3′ [ 30 , 35 ], whereas, the reduction of the ∆ 2 ′ ,3 ′ in chizhine D ( 3 ), cochlearin G ( 4 ), applanatumols S, T ( 5 , 6 ) and ganomycin E ( 9 ) was occurred [ 30 , 31 , 34 ].…”

Section: Chemical Structures and Bioactivities Of Gmsmentioning

confidence: 99%

“…Since the discovery of ganomycins A and B [ 12 ], more than 100 aromatic meroterpenoids, derived by a hybrid of shikimic acid and mevalonic acid biogenetical pathway, were isolated from the genus Ganoderma (Ganodermataceae) [ 13 ]. Ganoderma meroterpenoids (GMs) have attracted increasing attention because they showed diverse structural skeletons and series of bioactivities, such as NO production inhibitory [ 14 ], anti-oxidant [ 15 , 16 ], anti-allergic [ 17 , 18 ], anti-fibrotic [ 19 ], anti-Acetyl cholinesterase (AChE) [ 20 ], cytotoxic [ 21 ], antimicrobial [ 12 ], and aldose reductase inhibitory activities [ 22 ]. As a result, chemists have synthesized polycyclic meroterpenoids by employing many steps [ 23 – 26 ].…”

Section: Introductionmentioning

confidence: 99%

Meroterpenoids from Ganoderma Species: A Review of Last Five Years

Peng

Qiu

2018

Nat. Prod. Bioprospect.

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Meroterpenoids are hybrid natural products that partially originate from the terpenoid pathway. Ganoderma meroterpenoids (GMs) are a type of meroterpenoids containing a 1,2,4-trisubstituted phenyl and a polyunsaturated terpenoid part. Over last 5 years, great efforts have been made to conduct phytochemistry research on the genus Ganoderma, which have led to the isolation and identification of a number of GMs. These newly reported GMs showed diverse structures and a wide range of biological activities. This review gives an overview of new GMs from genus Ganoderma and their biological activities and biosynthetic pathway, focusing on the period from 2013 until 2018.Graphical Abstract

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Total Synthesis of Ganoderma Meroterpenoids – Progresses since 2014

Kawamoto,

Ito

2024

Asian J Org Chem

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Meroterpenoids isolated from fungi of the Ganoderma family have received much attention owing to their unique structures and diverse biological activities. A number of Ganoderma meroterpenoids have been isolated since 2000 and many total syntheses and synthetic studies have since been reported. In this review, we highlight fifteen total syntheses conducted from 2014 to 2023 of polycyclic Ganoderma meroterpenoids classified according to the connection pattern of the dihydroquinone with the terpenoid structure. The selected studies illustrate how the molecular complexity was constructed by unique tactics.

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Antioxidant farnesylated hydroquinones from Ganoderma capense

Cited by 31 publications

References 33 publications

A Ganoderma-Derived Compound Exerts Inhibitory Effect Through Formyl Peptide Receptor 2

A Ganoderma-Derived Compound Exerts Inhibitory Effect Through Formyl Peptide Receptor 2

Meroterpenoids from Ganoderma Species: A Review of Last Five Years

Total Synthesis of Ganoderma Meroterpenoids – Progresses since 2014

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