Antioxidant flavonol glycosides in mulberry (Morus alba L.) leaves isolated based on LDL antioxidant activity

Katšube, Takao; Imawaka, Naoto; Kawano, Yasuhiro; Yamazaki, Yoshimitsu; Shiwaku, Kuninori; Yamane, Yoshihiro

doi:10.1016/j.foodchem.2005.03.019

Cited by 321 publications

(260 citation statements)

References 29 publications

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“…Several flavonoids and their structurally related compounds have been shown to inhibit lipid peroxidation (Katsube et al 2006).…”

Section: Discussionmentioning

confidence: 99%

Gastroprotective effect of Byrsonima sericea DC leaf extract against ethanol-induced gastric injury and its possible mechanisms of action

Rodrigues¹,

Morais²,

Souza³

et al. 2012

An. Acad. Bras. Ciênc.

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Byrsonima sericea leaves are extensively used in folk medicine in Brazil against gastric disorders. This study investigated the chemical constituents of B. sericea leaf ethanolic extract (BSLE) and its potential gastroprotective activity, with its possible mechanism of the action using ethanol to induce gastric mucosal damage in mice. The phytochemical analysis was carried out to identify the active constituents present in the extract, and the HPLC analysis was performed for the identification of flavonoids. BSLE at oral doses of 125, 250 and 500 mg/kg markedly attenuated the ethanol-evoked gastric lesions by 53.2, 84.9 and 87.6 %, respectively. The BSLE (250 mg/kg) prevented the depletion of gastric mucus and gastric mucosal nonproteic-sulfhydryl groups, SOD and CAT, as well as the increase in the MDA content promoted by absolute ethanol. Moreover, the effect of BSLE against ethanol damage was found to be significantly reduced in mice pretreated with Capsazepine (i.p.), L-NAME (i.p.) or glibenclamide (i.p.), the respective blockers/inhibitors of TRPV1, NO synthase and K+ATP channel. The phytochemical investigation on BSLE revealed the presence of flavonoids rutin, isoquercitrin, kaempferol 3-O-rutinoside and quercetin, which are compounds well known for their antioxidant and gastroprotective properties. These results suggest that BSLE affords gastroprotection through multiple mechanisms, which may be helpful in the treatment of pathologies associated with gastric dysfunctions.

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“…Several flavonoids and their structurally related compounds have been shown to inhibit lipid peroxidation (Katsube et al 2006).…”

Section: Discussionmentioning

confidence: 99%

Gastroprotective effect of Byrsonima sericea DC leaf extract against ethanol-induced gastric injury and its possible mechanisms of action

Rodrigues¹,

Morais²,

Souza³

et al. 2012

An. Acad. Bras. Ciênc.

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“…For this reason, many ex vivo biochemical models based on biomarkers such as DNA and LDL have frequently been used for the assessment of the protective roles of antioxidants. The copper-induced LDL peroxidation method uses copper (II) to initiate the oxidation reaction, and antioxidant activity is measured by spectrophotometric monitoring of the peroxidation product, the conjugated dienes, over time (Katsube et al 2006). The Comet assay, or single cell gel electrophoresis (SCGE) assay, has been used to assess oxidative damage to DNA, and has only recently been adapted to measure the antioxidative role of phytochemicals (Singh et al 1988;Russo et al 2003;O'Brien et al 2006).…”

Section: Ex Vivo Biochemical Models and Cell Culture Techniquementioning

confidence: 99%

Exploration and characterization of bioactive phytochemicals in native Canadian plants for human health

Tsao¹,

Liu²

2007

Can. J. Plant Sci.

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Tsao, R. and Liu, Z. 2007. Exploration and characterization of bioactive phytochemicals in native Canadian plants for human health. Can. J. Plant Sci. 87: [1045][1046][1047][1048][1049][1050][1051][1052][1053]. The boundary between medicine and food is not always clear in many ancient cultures. Many plants have traditionally been used in both culinary and healing practices. Herbs, in particular, have shown this dual functionality. Scientific information on herbal medicines has been limited to exotic plants, and only a few herbal plants native to, or grown in, Canada, such as American ginseng, Echinacea, St. John's wort and feverfew, have been studied. Thorough investigations have not been carried out, and there is a lack of information about native Canadian plants and their potential as medicinal plants, particularly in terms of their chemical composition, biological activity and potential use for disease prevention. Also, from the marketing point of view, many of the existing herbs have only a small niche in the marketplace, so over production and consequent price depression can easily happen, as seen in the ginseng industry. There is obviously a need for multidisciplinary collaboration among herbalists, botanists, chemists and other scientists, since introducing native plants into mass production requires knowledge of environmental impact, genetic variability and the effects of other factors on the bioactive components. This review is intended to introduce the needs, techniques and challenges of such an approach with an emphasis on chemical and biochemical characterizations. Cette dualité se remarque particulièrement chez les fines herbes. En homéopathie, les données scientifiques se bornent aux espèces exotiques et seules quelques herbacées parmi les plantes indigènes du Canada ont été étudiées, notamment le ginseng américain, l'échinacée, le millepertuis et le chrysanthème-matricaire. Aucune étude exhaustive n'a été entreprise et on manque d'informations sur les plantes indigènes du Canada ainsi que leur potentiel en tant que plantes médicinales. On ne sait notamment pas grand-chose sur leur composition chimique, leur activité biologique ni leur utilité éventuelle pour prévenir la maladie. Du point de vue commercial, bon nombre des fines herbes existantes occupent une très petite niche sur le marché, de sorte qu'il peut y avoir aisément surproduction et chute des prix, ainsi qu'on a pu le voir dans l'industrie du ginseng. Manifestement, les homéopathes, les botanistes, les chimistes et d'autres scientifiques doivent collaborer, car le passage des plantes indigènes à la production de masse exige une solide connaissance des répercussions sur l'environnement, de la variabilité génétique et des effets d'autres paramètres sur les composés bioactifs. Cet article expose les besoins, les techniques et les enjeux d'une telle approche, en insistant sur la caractérisation chimique et biochimique.

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“…Mulberry leaf extract acts as a natural inhibitor of α-glucosidase due to Deoxynojirimycin (DNJ) and its derivatives (Katsube et al, 2006). Extractive from leaves of morus alba suppressed the post prandial blood glucose and insulin (Nakamura et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Effect of Deoxynojirimycin on Glycogenesis in Liver of Mice, Mus norvegicus albinus

Bajpai¹,

Rao²,

Agamkumar³

2016

Int.J.Curr.Res.Aca.Rev.

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Antioxidant flavonol glycosides in mulberry (Morus alba L.) leaves isolated based on LDL antioxidant activity

Cited by 321 publications

References 29 publications

Gastroprotective effect of Byrsonima sericea DC leaf extract against ethanol-induced gastric injury and its possible mechanisms of action

Gastroprotective effect of Byrsonima sericea DC leaf extract against ethanol-induced gastric injury and its possible mechanisms of action

Exploration and characterization of bioactive phytochemicals in native Canadian plants for human health

Effect of Deoxynojirimycin on Glycogenesis in Liver of Mice, Mus norvegicus albinus

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