Antioxidant, free radical scavenging capacity and antimicrobial activities of Mirabilis jalapa

Oladunmoye, M. K.

doi:10.5897/jmpr09.281

Cited by 16 publications

(14 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The extraction was carried out according to Oladunmoye (2012). The resulting weight of the powdered form was 500 g which was exhaustively extracted at a ratio of 1:4 (powder weight to solvent volume) with multiple solvents namely n-hexane, water and methanol.…”

Section: Preparation Of Plant Extractmentioning

confidence: 99%

In-ovo biological activities of Phyllanthus amarus leaf extracts against Newcastle disease virus

Faeji¹,

Oladunmoye²,

Adebayo³

et al. 2017

J. Med. Plants Res.

View full text Add to dashboard Cite

Newcastle disease virus is a paramyxovirus which causes Newcastle disease in birds. Investigation was done on the effect of leaf extract of Phyllanthus amarus against Newcastle disease virus (NDV) using an in-ovo assay. Nine to eleven day-old viable embryonated chicken eggs (ECE) were used for the assay, these were divided into six groups of six eggs each. Methanol, aqueous and n-hexane extracts of the plant leaves were administered to the various groups at concentrations varying from 50 to 5 mg/ml. Embryonated eggs were incubated and embryo survival was monitored daily. Negative control and diluents control groups received phosphate buffer saline (PBS) and dimethly suphoxide (DMSO), respectively. The other group was uninoculated while a virus control group received 100 EID 50 /0.1 ml NDV alone. Bacteria free allantoic fluid from the embryonated eggs in different treatment groups were harvested and collected for spot hemagglutination (HA) test and HA assay to detect the presence of NDV viral particles and the viral titre, respectively. Leaf extracts were assayed for presence of phytochemicals and antioxidant potentials. It was observed from the results that the extract was toxic to the embryo at a concentration above 50 mg/ml and further results showed that the HA viral titre reduction was directly proportional to increasing extract concentration. The phytochemical assays of leaf extract revealed the presence of phytochemicals including alkaloids, tannins, saponins, flavonoids, phenols, steroids, glycosides. The current findings have demonstrated that leaf extract from P. amarus has potentials of medicinal value as well as antiviral activity against NDV in-ovo. Further experimental assays using live animal models are recommended to validate the use of P. amarus plant extract in therapeutic measure in chickens.

show abstract

Section: Preparation Of Plant Extractmentioning

confidence: 99%

In-ovo biological activities of Phyllanthus amarus leaf extracts against Newcastle disease virus

Faeji¹,

Oladunmoye²,

Adebayo³

et al. 2017

J. Med. Plants Res.

View full text Add to dashboard Cite

show abstract

“…Clinically, inflammation is the second phase of the healing process and is characterized by erythema, swelling, and temperature increases that are often associated with pain. Furthermore, the antibacterial activity of the M. jalapa L. extract enhances the acceleration of wound healing [14]. This could be particularly useful in treating open wounds, where infection is highly likely and would inhibit the healing process [15].…”

Section: Dosementioning

confidence: 99%

Effect of the Water Extract of the Four O’clock Herb (Mirabilis Jalapa L.) on the Healing of Open Wounds in Rats

Puspasari

Saputri

2018

Int J App Pharm

View full text Add to dashboard Cite

Objective: This study aimed to analyze the effect on wound healing following treatment with a water extract of Mirabilis jalapa L. by investigating wound contraction and the associated histopathological changes in rat skin. Methods:Male Sprague-Dawley rats were divided into five groups, namely negative control, positive control (povidone-iodine), dose 1, dose 2, and dose 3. A 20-×10-mm rectangular wound area was created for the test. In dose 1, 2, and 3 groups, the corresponding dose variation of a 0.5-mL M. jalapa L. water extract (dose 1: 5% v/v, ≈243.1 mg/kg body weight BW; dose 2: 10% v/v, ≈486.2 mg/kg BW; and dose 3: 20% v/v, ≈972.4 mg/kg BW) was topically applied for 14 days on open wounds of rats. Widespread wound contractions were measured on days 1, 3, 5, 7, 9, 11, and 13, and histopathological changes in the skin were observed on day 15 using hematoxylin and eosin staining.Results: The M. jalapa L. water extract accelerated wound healing. The optimal dose was found to be 20% v/v (≈972.4 mg/kg BW). Conclusion: M. jalapa L. extracts are potential healing agents for open wounds. Puspasari and Saputri contraction parameters and histopathological indicators. An effective dose of 972.4 mg/kg body weight was determined.

show abstract

“…The filtrates were then separately concentrated using Rotary Evaporator to10% of their original volumes at 37 o C -40 o C. These were concentrated to complete dryness in water bath. The extracts were stored in a refrigerator from where aliquots were used for the phytochemical and antioxidant capacity assay (Oladunmoye, 2012).…”

Section: Plant Preparation and Extractionmentioning

confidence: 99%

“…The primary consists of amino acids, proteins, sugars and the secondary comprises the alkaloids, flavonoids, tannins, terpenoids, saponin and others. Majority of the phytochemicals have been known to exert valuable therapeutic and pharmacological effects such as insecticidal, bactericidal, fungicidal, anti-parasitic, anti-constipative and probable antiviral effects (Oladunmoye, 2012).…”

Section: Introductionmentioning

confidence: 99%

Comparative Evaluation of Phytochemical Constituents and Antioxidant Capacity of Some Ethnomedicinal Plants Used In Western Nigeria

Faeji¹,

Oladunmoye²

2017

IOSRJPBS

View full text Add to dashboard Cite

Antioxidant, free radical scavenging capacity and antimicrobial activities of Mirabilis jalapa

Cited by 16 publications

References 1 publication

In-ovo biological activities of Phyllanthus amarus leaf extracts against Newcastle disease virus

In-ovo biological activities of Phyllanthus amarus leaf extracts against Newcastle disease virus

Effect of the Water Extract of the Four O’clock Herb (Mirabilis Jalapa L.) on the Healing of Open Wounds in Rats

Comparative Evaluation of Phytochemical Constituents and Antioxidant Capacity of Some Ethnomedicinal Plants Used In Western Nigeria

Contact Info

Product

Resources

About