Antioxidant independent actions of vitamin E in modulating gene expression

Valentino, Stephen; Ghelfi, Mikel; Zunica, Elizabeth R. M.; Stamper, Michaela; Hickman, Sarah; Hwang, Shannon; Young, Ericka; Atkinson, Jeffrey; Manor, Danny

doi:10.1016/j.freeradbiomed.2018.10.113

Cited by 5 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Vit E is a fat-soluble vitamin that is also known as a powerful anti-oxidant. Antioxidants protect the body's lymphocyte against the damaging effects of free radicals and can reduce the risk of dangerous diseases such as cancer, heart disease, or even Alzheimer [22]. A sufficient amount of Vit E boosts the immune system by increasing the phagocytosis of macrophage and increasing antibody production.…”

Section: Discussionmentioning

confidence: 99%

Immunopotentiotor Effect of α-Tocopherol on Cytokine Expression in the Lymphocytes in the Elderly People

Darabi

Haghighat

Mahdavi

2021

Immuno

View full text Add to dashboard Cite

Background: Aging is associated with attenuation of immune responses. Studies show that old people are vulnerable to infectious diseases such as influenza. α-Tocopherol as an immunomodulator affects immune responses. In the present study, the effect of α-tocopherol, on lymphocyte responses i.e. interferon-gamma (IFN-γ), Tumor Necrosis Factor-alpha (TNF-α), and nuclear factor-κB (NF-κB) in elderly individuals was evaluated. Materials and Methods: Heparinized blood samples were prepared from 10 elderly individuals (n=10, age >80 years) as the experimental group and 10 young individuals (n= 10, 20-40 years) as the control group. The separated Peripheral Blood Mononuclear Cells (PBMCs) of aged and young individuals were used for treatment with 2 μg/mL of α-tocopherol and 2 μg/mL of Purified Protein Derivative (PPD) after 12 and 24 h incubation period. After isolation of total RNA and synthesize of cDNA, the gene expressions of IFN-γ, TNF-α, and NF-κB were evaluated by real-time PCR method. β-Actin gene was considered as the internal control gene. Results: Results showed that treatment with α-tocopherol increased the IFN-γ expression in old and young lymphocyte groups. The mRNA level of NF-κB increased in the PPD group after 12 h in both old and young groups (p <0.05). There were no alterations in TNF-α expression in both groups. Conclusion: It seems that α-tocopherol is effective in the promotion of cytokine responses in old individuals and may be useful as a supplement for improving the immune system of elderly people.

show abstract

Section: Discussionmentioning

confidence: 99%

Immunopotentiotor Effect of α-Tocopherol on Cytokine Expression in the Lymphocytes in the Elderly People

Darabi

Haghighat

Mahdavi

2021

Immuno

View full text Add to dashboard Cite

show abstract

“…Most importantly, in addition to the well-known direct antioxidant effects, the role of vitamin E on gene expression has also been reported. This aspect is the most relevant as it represents an alternative, antioxidant activity-independent anti-aging mechanism [79,80].…”

Section: Targeted Experimentalmentioning

confidence: 99%

An Updated Overview on the Role of Small Molecules and Natural Compounds in the “Young Science” of Rejuvenation

Ribaudo

Gianoncelli

2023

Antioxidants

View full text Add to dashboard Cite

Aging is a gradual process that occurs over time which leads to a progressive decline of cells and tissues. Telomere shortening, genetic instability, epigenetic alteration, and the accumulation of misfolded proteins represent the main hallmarks that cause perturbed cellular functions; this occurs in conjunction with the progression of the so-called “aging clocks”. Rejuvenation aims to influence the natural evolution of such aging clocks and to enhance regenerative capacity, thus overcoming the limitations of common anti-aging interventions. Current rejuvenation processes are based on heterochronic parabiosis, cell damage dilution through asymmetrical cell division, the excretion of extracellular vesicles, the modulation of genetic instability involving G-quadruplexes and DNA methylation, and cell reprogramming using Yamanaka factors and the actions of antioxidant species. In this context, we reviewed the most recent contributions that report on small molecules acting as senotherapeutics; these molecules act by promoting one or more of the abovementioned processes. Candidate drugs and natural compounds that are being studied as potential rejuvenation therapies act by interfering with CDGSH iron-sulfur domain 2 (CISD2) expression, G-quadruplex structures, DNA methylation, and mitochondrial decay. Moreover, direct and indirect antioxidants have been reported to counteract or revert aging through a combination of mixed mechanisms.

show abstract

“…Previous investigations reported the free radical quenching activity principally modulates gene expression in the cells. It protects against exposure to UV radiation, which has a favorable effect on lipid peroxidation and prevents from skin illnesses (Keen & Hassan, 2016;Valentino et al, 2018). The in vivo study revealed that the α-tocopherol effectively transfers hydrogen atoms to lipid free radicals and forms nonradical lipid products via the α-tocopheroxyl radical (Yamauchi, 1997).…”

Section: Vitamin Ementioning

confidence: 99%

An emerging natural antioxidant therapy for COVID‐19 infection patients: Current and future directions

Shrivastava

Sahu

Cecchi³

et al. 2023

Food Frontiers

View full text Add to dashboard Cite

Severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) affects millions of people worldwide. The article aims to review the therapeutic perspective on natural antioxidants, their mechanism of action, pharmacokinetics in management and cure of COVID‐19/ SARS‐CoV‐2 infection. We conducted a literature search including World Health Organization and National Institute of Health guidelines and clinical trials registered with ClinicalTrials.gov limited to antioxidants in COVID‐19 management. Elderly, immunocompromised patients, and others with underlying health conditions or multiple comorbidities have a high mortality rate. Disrupted redox homeostasis and oxidative stress seem to be biological pathways that may increase personal vulnerability to infection. Antioxidants like vitamins C, D, E, epigallocatechin‐3 gallate, and morin have been reported to protect against COVID‐19 disease. Reactive oxygen species are immunological regulatory elements of viral replication. Natural antioxidants exhibit potential action in preventing inflammation and organ dysfunction during viral infection. They also increase glutathione level, oxygenation rate, and immunological responses in the treatment of sepsis and acute respiratory distress syndrome. No wonder the selection of prevention, treatment, and cure of COVID‐19 and SARS‐CoV‐2 mainly depends upon the antiviral and immunoregulatory activity which they possess. Yet, their efficacy against COVID‐19 is of great concern and demands extensive study.

show abstract

Antioxidant independent actions of vitamin E in modulating gene expression

Cited by 5 publications

References 0 publications

Immunopotentiotor Effect of α-Tocopherol on Cytokine Expression in the Lymphocytes in the Elderly People

Immunopotentiotor Effect of α-Tocopherol on Cytokine Expression in the Lymphocytes in the Elderly People

An Updated Overview on the Role of Small Molecules and Natural Compounds in the “Young Science” of Rejuvenation

An emerging natural antioxidant therapy for COVID‐19 infection patients: Current and future directions

Contact Info

Product

Resources

About