Antioxidant intake is associated with semen quality in healthy men

Eskenazi, Brenda; Kidd, Sharon A.; Marks, Amy R.; Sloter, Eddie D.; Block, Gladys; Wyrobek, Andrew J.

doi:10.1093/humrep/deh725

Cited by 280 publications

(186 citation statements)

References 29 publications

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“…In Eskenazi's study vitamins C, E and beta-carotene were associated with semen quality in 97 healthy non-smoking men. They revealed that a high intake of antioxidants is associated with better sperm quality [56].…”

Section: Discussionmentioning

confidence: 99%

Effect of beta-carotene on titanium oxide nanoparticles-induced testicular toxicity in mice

Orazizadeh

Khorsandi

Absalan

et al. 2014

J Assist Reprod Genet

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Objective This study evaluated the protective effect of betacarotene (BC) on titanium oxide nanoparticle (TNP) induced spermatogenesis defects in mice. Materials and methods Thirty-two NMRI mice were randomly divided into four groups. BC group received 10 mg/kg of BC for 35 days. TNP group received 300 mg/kg TNP for 35 days. TNP+BC group initially received 10 mg/kg BC for 10 days and was followed by concomitant administration of 300 mg/kg TNP for 35 days. Control group received only normal saline for 35 days. Epididymal sperm parameters, testicular histopathology, spermatogenesis assessments and testosterone assay were performed for evaluation of the TNP and BC effects on testis. Results Serum testosterone levels were markedly decreased in TNP-intoxicated mice. Epididymal sperm parameters including sperm number, motility and percentage of abnormality were significantly changed in TNP-intoxicated mice (p < 0.01). Histopathological criteria such as epithelial vacuolization, sloughing of germ cells and detachment were significantly increased in TNP-intoxicated mice (p<0.001). BC+TNP treatment significantly prevented these changes (p<0.05). BC also significantly elevates testosterone levels in BC+TNP group compared to TNP-treated mice (p<0.01). Discussion and conclusion The results of this study demonstrated that BC improved the spermatogenesis defects in TNPtreated mice. BC had a potent protective effect against the testicular toxicity and might be clinically useful.

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Section: Discussionmentioning

confidence: 99%

Effect of beta-carotene on titanium oxide nanoparticles-induced testicular toxicity in mice

Orazizadeh

Khorsandi

Absalan

et al. 2014

J Assist Reprod Genet

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“…Taking into account the latest data released by the Society for Assisted Reproductive Technology (SART, www.sart.org), corresponding to IVF patients in 2011, the incidence of male factor was: male factor (17 %), mixed male and female factor (18 %), other factors (8 %) and unknown factors (12 %). The aetiology of diminished semen quality is poorly understood, although both environmental and occupational factors, as well as lifestyle, have been implicated [5,13].…”

Section: Introductionmentioning

confidence: 99%

Coenzyme Q10 and male infertility: a meta-analysis

Lafuente

González-Comadran

Solà

et al. 2013

J Assist Reprod Genet

139

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Objective To evaluate the effect of coenzyme Q10 treatments in male infertility, specifically in these parameters: live birth and pregnancy rates, CoQ10 seminal concentration, sperm concentration, and sperm motility. Materials and methods Systematic review and meta-analysis in male infertility patients with CoQ10 oral treatments. Three trials were included: 149 males in CoQ10 group and 147 males in placebo group. Results None of the included trials provided any data regarding live births. The results of this meta-analysis show that supplementing infertile men with CoQ10 does not increase pregnancy rates. The analysis showed, among patients receiving CoQ10 treatment, a statistically significant increase in: CoQ10 seminal concentration (RR 49.55, 95 % CI 46.44 to 52.66, I 2 =17 %), sperm concentration (RR 5.33, 95 % CI 4.18 to 6.47, I 2 =58 %), and sperm motility (RR 4.50, 95 % CI 3.92 to 5.08, I 2 =0 %)Conclusion There is no evidence in the literature that CoQ10 increases either live birth or pregnancy rates, but there is a global improvement in sperm parameters. Adequately powered, robust trials of individual and combination antioxidant therapies are required to guide clinical practice.

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“…Eighty seven men with decreased sperm motility (asthenozoospermia) received Vitamin E (100 mg 3 times daily) for 6 months had significantly decreased levels of lipid peroxidation product and improved sperm motility as compared to the placebo group [49]. Higher levels of Vitamin E intake were associated with higher levels of progressive sperm motility [50].…”

Section: Resultsmentioning

confidence: 99%

Effect of Halawa Tahinia Alone or with Ginger and Cinnamon on Sex Hormones in Adult Male Rats

Rabeh¹

2016

IJNFS

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Abstract:This study was performed to investigate the effect of halawa tahinia alone or in combination with ginger and cinnamon on sex hormones as well as serum antioxidant levels. Thirty Wistar adult male rat were divided into five groups, control group fed on basal diet only and test groups (n=24) divided into 4 groups as follow, group (1) fed on basal diet supplemented with halawa tahinia at the level of (15%), while the other three groups were fed on basal diet supplemented with halawa tahinia (15%) and were given orally (500 mg/kg/day) dried ginger, (500 mg/kg/day) dried cinnamon, both dried ginger and cinnamon (500 mg/kg/day) respectively for 8 weeks. The results indicated that, halawa tahinia have a high nutritive value. The obtained results revealed also that, oral administration of ginger and/ or cinnamon with halawa tahinia caused a significant (p<0.05) protective effects on testes due to increasing the levels of serum total testosterones, follicular stimulating hormone (FSH) and luteinizing hormone (LH) also increasing serum total antioxidants capacity (TAC) levels with decreasing malondialdehyde (MDA) level as well as have no deleterious effects on liver functions as compared to control group. Moreover, both ginger and cinnamon administration has a synergistic effect on infertility due to their antioxidant properties. In conclusion: These results provide scientific evidence to substantiate the traditional use of cinnamon and ginger as a drink as well as Halawa tahinia in improving infertility in male rats which might be a product for their potent antioxidant properties and androgenic activities.

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Antioxidant intake is associated with semen quality in healthy men

Abstract: In a convenience sample of healthy non-smoking men from a non-clinical setting, higher antioxidant intake was associated with higher sperm numbers and motility.

Cited by 280 publications

References 29 publications

Effect of beta-carotene on titanium oxide nanoparticles-induced testicular toxicity in mice

Effect of beta-carotene on titanium oxide nanoparticles-induced testicular toxicity in mice

Coenzyme Q10 and male infertility: a meta-analysis

Effect of Halawa Tahinia Alone or with Ginger and Cinnamon on Sex Hormones in Adult Male Rats

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