Antioxidant lignans sesamin and sesamolin in sesame (Sesamum indicum L.): A comprehensive review and future prospects

Dossou, Senouwa Segla Koffi; Xu, Fangtao; Dossa, Komivi; Zhou, Rong; Zhao, Yingzhong; WANG, Lin-hai

doi:10.1016/j.jia.2022.08.097

Cited by 25 publications

(12 citation statements)

References 127 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…qRT-PCR analysis also showed that the “C” allele is favorable for lignans biosynthesis during seed development ( Figure S9B ). In sesame accessions with the “C” allele, SiNST1 is highly expressed at the key stages (10 to 20 DPA) of sesamin and sesamolin biosynthesis [ 12 , 30 , 41 ]. While in sesame accessions with the “A” allele, SiNST1 is mostly expressed at the early stages of seed development.…”

Section: Resultsmentioning

confidence: 99%

Resequencing of 410 Sesame Accessions Identifies SINST1 as the Major Underlying Gene for Lignans Variation

Dossou

Song

Liu

et al. 2023

IJMS

View full text Add to dashboard Cite

Sesame is a promising oilseed crop that produces specific lignans of clinical importance. Hence, a molecular description of the regulatory mechanisms of lignan biosynthesis is essential for crop improvement. Here, we resequence 410 sesame accessions and identify 5.38 and 1.16 million SNPs (single nucleotide polymorphisms) and InDels, respectively. Population genomic analyses reveal that sesame has evolved a geographic pattern categorized into northern (NC), middle (MC), and southern (SC) groups, with potential origin in the southern region and subsequent introduction to the other regions. Selective sweeps analysis uncovers 120 and 75 significant selected genomic regions in MC and NC groups, respectively. By screening these genomic regions, we unveiled 184 common genes positively selected in these subpopulations for exploitation in sesame improvement. Genome-wide association study identifies 17 and 72 SNP loci for sesamin and sesamolin variation, respectively, and 11 candidate causative genes. The major pleiotropic SNPC/A locus for lignans variation is located in the exon of the gene SiNST1. Further analyses revealed that this locus was positively selected in higher lignan content sesame accessions, and the “C” allele is favorable for a higher accumulation of lignans. Overexpression of SiNST1C in sesame hairy roots significantly up-regulated the expression of SiMYB58, SiMYB209, SiMYB134, SiMYB276, and most of the monolignol biosynthetic genes. Consequently, the lignans content was significantly increased, and the lignin content was slightly increased. Our findings provide insights into lignans and lignin regulation in sesame and will facilitate molecular breeding of elite varieties and marker-traits association studies.

show abstract

Section: Resultsmentioning

confidence: 99%

Resequencing of 410 Sesame Accessions Identifies SINST1 as the Major Underlying Gene for Lignans Variation

Dossou

Song

Liu

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

“…It exerts various pharmacological impacts, such as prevention of hyperlipidemia, hypertension, and carcinogenesis, as well as anticancer and chemopreventive activity in vitro and in vivo [ 445 , 446 ], and antioxidant and anti-inflammatory characteristics [ 447 , 448 ]. Plants reported to contain sesamin are Paulownia tomentosa Staud., Phyllarthron comorense , Justicia simplex , Hyptis tomentosa , Anacyclus pyrethrum , Artemisia absinthium , Artemisia gorgonum , Chrysanthemum cinerariaefolium , C. frutescens , C. indicum , Diotis maritima , Eupatorium ageratina , E. ritonia , E. fleischmannia , Otanthus maritimus , Aptosimum spinescens , Gmelina arborea Roxb., Acanthopanax senticosus , A. sessiliflorum , Eleutherococcus divaricatus , Asarum sieboldii , Aristolochia cymbifera , Alnus glutinosa , Salicomia europaea , Austrocedrus chilensis , Evodia micrococca , Fagara xanthoxyloides , Fagara tessmannii , Fagara heitzii , Micromelum minutum , Melicope glabra , Spiranthera odoratissima , Flindersia pubescens , Zanthoxylum naranjillo , Zanthoxylum tingoassuiba , Zanthoxylum piperitum , Zanthoxylum nitidum , Zanthoxylum flavum , Zanthoxylum alatum Roxb., Zanthoxylum bungeanum , Ginkgo biloba , Machilus glaucescens , Ocotea usambarensis , Aiouea trinervis Meisn., Talauma hodgsonii , Magnolia spp., Picea abies , Macropiper excelsum , Piper sarmentosum , Sesamum indicum , S. radiatum , S. mulayanum , S. malabaricum , S. alatum , S. angustifolium , S. angolense , S. calycinum , Anemopsis californica , Quercus frainetto Ten., Vernicia fordii , Jatropha curcas , Larrea tridentata , Morinda citrifolia , Glossostemon bruguieri , Ligustrum japonicum , and Triclisia sacleuxii [ 449 ]. Sesamin could boost the proliferation and adhesion of intestinal probiotics, leading to modulating gut microbiota, which provided the basis for sesamin as a food-borne functional parameter for improving intestinal health [ 450 ].…”

Section: The Important Health Benefits Of Lignan (Sesamin)mentioning

confidence: 99%

Therapeutic Potential of Phenolic Compounds in Medicinal Plants—Natural Health Products for Human Health

2023

View full text Add to dashboard Cite

Phenolic compounds and flavonoids are potential substitutes for bioactive agents in pharmaceutical and medicinal sections to promote human health and prevent and cure different diseases. The most common flavonoids found in nature are anthocyanins, flavones, flavanones, flavonols, flavanonols, isoflavones, and other sub-classes. The impacts of plant flavonoids and other phenolics on human health promoting and diseases curing and preventing are antioxidant effects, antibacterial impacts, cardioprotective effects, anticancer impacts, immune system promoting, anti-inflammatory effects, and skin protective effects from UV radiation. This work aims to provide an overview of phenolic compounds and flavonoids as potential and important sources of pharmaceutical and medical application according to recently published studies, as well as some interesting directions for future research. The keyword searches for flavonoids, phenolics, isoflavones, tannins, coumarins, lignans, quinones, xanthones, curcuminoids, stilbenes, cucurmin, phenylethanoids, and secoiridoids medicinal plant were performed by using Web of Science, Scopus, Google scholar, and PubMed. Phenolic acids contain a carboxylic acid group in addition to the basic phenolic structure and are mainly divided into hydroxybenzoic and hydroxycinnamic acids. Hydroxybenzoic acids are based on a C6-C1 skeleton and are often found bound to small organic acids, glycosyl moieties, or cell structural components. Common hydroxybenzoic acids include gallic, syringic, protocatechuic, p-hydroxybenzoic, vanillic, gentistic, and salicylic acids. Hydroxycinnamic acids are based on a C6-C3 skeleton and are also often bound to other molecules such as quinic acid and glucose. The main hydroxycinnamic acids are caffeic, p-coumaric, ferulic, and sinapic acids.

show abstract

“…Sesame has a smooth flavor and a considerably aromatic odor, abundant in protein, fat, vitamins, minerals, and dietary fibers; thus, it presents a superior nutritional advantage [82]. The recently discovered sesaminol (lignan), has increased antioxidant features, while sesamin and sesamolin have almost no antioxidative effect, but they exert proantioxidant activity (powerful antioxidants through in vivo metabolic alterations) [83,84]. Sesame has efficient digestibility, and through the consumption of 1-3 g of sesame daily, important health-promoting effects can be obtained [85].…”

Section: Legume-based Nut-based and Seed-based Sourcesmentioning

confidence: 99%

Plant-Based Dairy Alternatives—A Future Direction to the Milky Way

Plamada

Teleky

Nemeş

et al. 2023

Foods

View full text Add to dashboard Cite

One significant food group that is part of our daily diet is the dairy group, and both research and industry are actively involved to meet the increasing requirement for plant-based dairy alternatives (PBDAs). The production tendency of PBDAs is growing with a predictable rate of over 18.5% in 2023 from 7.4% at the moment. A multitude of sources can be used for development such as cereals, pseudocereals, legumes, nuts, and seeds to obtain food products such as vegetal milk, cheese, cream, yogurt, butter, and different sweets, such as ice cream, which have nearly similar nutritional profiles to those of animal-origin products. Increased interest in PBDAs is manifested in groups with special dietary needs (e.g., lactose intolerant individuals, pregnant women, newborns, and the elderly) or with pathologies such as metabolic syndromes, dermatological diseases, and arthritis. In spite of the vast range of production perspectives, certain industrial challenges arise during development, such as processing and preservation technologies. This paper aims at providing an overview of the currently available PBDAs based on recent studies selected from the electronic databases PubMed, Web of Science Core Collection, and Scopus. We found 148 publications regarding PBDAs in correlation with their nutritional and technological aspects, together with the implications in terms of health. Therefore, this review focuses on the relationship between plant-based alternatives for dairy products and the human diet, from the raw material to the final products, including the industrial processes and health-related concerns.

show abstract

Antioxidant lignans sesamin and sesamolin in sesame (Sesamum indicum L.): A comprehensive review and future prospects

Cited by 25 publications

References 127 publications

Resequencing of 410 Sesame Accessions Identifies SINST1 as the Major Underlying Gene for Lignans Variation

Resequencing of 410 Sesame Accessions Identifies SINST1 as the Major Underlying Gene for Lignans Variation

Therapeutic Potential of Phenolic Compounds in Medicinal Plants—Natural Health Products for Human Health

Plant-Based Dairy Alternatives—A Future Direction to the Milky Way

Contact Info

Product

Resources

About