Antioxidant mesoporous Ce-doped bioactive glass nanoparticles with anti-inflammatory and pro-osteogenic activities

Zheng, Kai; Torre, Elisa; Bari, Alessandra; Taccardi, Nicola; Cassinelli, Clara; Morra, Marco; Fiorilli, Sonia Lucia; Vitale-Brovarone, C.; Iviglia, Giorgio; Boccaccını, Aldo R.

doi:10.1016/j.mtbio.2020.100041

Cited by 87 publications

(128 citation statements)

References 84 publications

Supporting

Mentioning

122

Contrasting

Order By: Relevance

“…Covalently immobilized CD47 on polytetrafluoroethylene (PTFE) surface could alleviate monocyte/macrophage inflammatory response and thus favor PTFE‐based vascular grafts having long‐lasting patency. [ 351 ] Besides, inorganic CeO 2− x NPs, [ 352 ] Ce‐doped bioglass NPs, [ 353 ] and biogenic lipoaspirate NPs [ 354 ] can also be used for antiinflammatory purpose. García and co‐workers demonstrated a dynamic, transdermal and noninvasive light activation strategy of cell‐adhesive RGD peptide to favor cell adhesion and vascularization but avoid inflammation and fibrous encapsulation.…”

Section: Immunoengineering Applicationsmentioning

confidence: 99%

Tailoring Materials for Modulation of Macrophage Fate

et al. 2021

View full text Add to dashboard Cite

Human immune system acts as a pivotal role in the tissue homeostasis and disease progression. Immunomodulatory biomaterials that can manipulate innate immunity and adaptive immunity hold great promise for a broad range of prophylactic and therapeutic purposes. This review is focused on the design strategies and principles of immunomodulatory biomaterials from the standpoint of materials science to regulate macrophage fate, such as activation, polarization, adhesion, migration, proliferation, and secretion. It offers a comprehensive survey and discussion on the tunability of material designs regarding physical, chemical, biological, and dynamic cues for modulating macrophage immune response. The range of such tailorable cues encompasses surface properties, surface topography, materials mechanics, materials composition, and materials dynamics. The representative immunoengineering applications selected herein demonstrate how macrophage-immunomodulating biomaterials are being exploited for cancer immunotherapy, infection immunotherapy, tissue regeneration, inflammation resolution, and vaccination. A perspective on the future research directions of immunoregulatory biomaterials is also provided.

show abstract

Section: Immunoengineering Applicationsmentioning

confidence: 99%

Tailoring Materials for Modulation of Macrophage Fate

et al. 2021

View full text Add to dashboard Cite

show abstract

“…In addition to tuning the concentration of impregnation solution, the incorporated amount of metal ions can also be controlled by adjusting the impregnation temperature. However, an elevated temperature can increase the risk of side product formation (e.g., metal or metal oxide nanoparticles) [18]. In this study, we successfully used SiO 2 NPs as the hard template, which ensured the homogenous size and shape of resulting HMBGNs (Figure 2).…”

Section: Synthesis Of Hollow Mesoporous Bioactive Glass Particlesmentioning

confidence: 99%

“…Recently, our group has introduced a post impregnation strategy to produce MBGNs in order to avoid particle aggregation and formation of metal or metal oxide nanoparticles as side products in sol–gel processes [ 18 ]. In the present study, we successfully produced binary SiO 2 -CaO HMBGNs by using the Stöber-derived silica particles as the hard template and combing etching and impregnation strategies.…”

Section: Introductionmentioning

confidence: 99%

Combination of Selective Etching and Impregnation toward Hollow Mesoporous Bioactive Glass Nanoparticles

et al. 2021

Self Cite

View full text Add to dashboard Cite

In this study, binary SiO2-CaO hollow mesoporous bioactive glass nanoparticles (HMBGNs) are prepared by combing selective etching and impregnation strategies. Spherical silica particles (SiO2 NPs) are used as hard cores to assemble cetyltrimethylammonium bromide (CTAB)/silica shells, which are later removed by selective etching to generate a hollow structure. After the removal of CTAB by calcination, the mesoporous shell of particles is formed. Calcium (Ca) is incorporated into the particles using impregnation by soaking the etched SiO2 NPs in calcium nitrate aqueous solution. The amount of incorporated Ca is tailorable by controlling the ratio of SiO2 NPs:calcium nitrate in the soaking solution. The produced HMBGNs are bioactive, as indicated by the rapid formation of hydroxyapatite on their surfaces after immersion in simulated body fluid. In a direct culture with MC3T3-E1 cells, HMBGNs were shown to exhibit concentration-dependent cytotoxicity and can stimulate osteogenic differentiation of MC3T3-E1 cells at concentrations of 1, 0.5, and 0.25 mg/mL. Our results indicate that the combination of selective etching and impregnation is a feasible approach to produce hierarchical HMBGNs. The produced hollow particles have potential in drug delivery and bone tissue regeneration applications, and should be further investigated in detailed in vitro and in vivo studies.

show abstract

“…Thus, Shruti et al [44] and its bioactivity was not altering significantly (a deficient HA was formed) [19]. Incorporation of cerium into BGs can enhance their antioxidant activity inducing anti-inflammatory, pro-osteogenesis, and pro angiogenesis activities [46]. V Nicolini [47] studied the catalase mimetic activity of Ce-containing BGs based on 45S5 composition and reported that these BGs have the ability to inhibit oxidative stress, by mimicking the catalase and superoxide dismutase activity.…”

Section: Effect Of Sr Zn and Ce Incorporation On The Properties Of Bgsmentioning

confidence: 99%

Effect of Sr, Zn, and Ce Substitution on the Properties of Bioactive Glasses

Atkinson¹

2020

AJBSR

View full text Add to dashboard Cite

As well as improving the life of people of all ages, a rise in the life expectancy of people has led to an increased demand for new restoring and augmentation materials that have applications in therapies for bone pathologies. Bioactive Glasses (BGs) have revolutionized the field of biomaterials as they have been generally accepted to be able to promote both hard and soft living tissues regeneration and self-repair. This brief review will discuss the effect of metallic ions substitution on the properties of bioactive glasses for tissue engineering and regenerative medicine applications. Bioactive Glasses an OverviewThe discovery and development of materials that interface with living host tissue i.e. fusion and co-joining of biomaterials with the human body are of great interest in the field of medical implants.A large amount of scientific effort has been devoted to find and manufacture biomaterials with improved properties. Traditionally, Bioactive Glasses (BGs) have been used to fill and restore bone defects. Recently, a high number of studies investigated and suggested BGs for bone replacement or skin repair and regeneration [1-5]. BGs are playing a fundamental role in the field of biomaterials due to their osteoconductive, osteo productive and osteo inductive properties. Prof. Hench [6], who initiated this subject of research with his colleagues in the early 1970s [6], gave us a good definition of bioactive materials; "A bioactive material is one that elicits a specific biological response at the interface of the material which results in the formation of a bond between the tissues and the material", Hench and his research team discovered that a certain composition of glass in the system SiO 2 -CaO-Na 2 O-P 2 O 5 was able to form a bond with bone once they are implanted. In fact, when these BGs are immersed biological fluids, a layer of Hydroxyapatite (HA) is deposited on their surface. The 45S5 bioactive glass composition, known as Bio glass (composition in wt.%: 45% SiO 2 , 24.5% Na 2 O, 24.5% CaO and 6% P 2 O 5 ), has approval of the US Food and Drug Administration (FDA). 45S5 Bioglass is used in clinical treatments of periodontal diseases as bone filler as well as in middle ear surgery [7].Bioactive Glasses (BGs) can be produced either by a traditional melt-quenching method or a sol-gel route. Three main BG production techniques are of most interest. The melt quenching technique is the traditional technique for the production of BGs [8]. The synthesis includes melting oxides of i.e. silica, calcium, and phosphate in adequate proportions according to the desired composition at temperature of around 1300 °C in a platinum crucible and quenched in a mold or in water (fritting procedure)-Annealing at 500 °C of the quenched glass is required to remove the internal stresses from the glasses [8].In the early 1990s BGs were for the first time prepared by the sol-gel process by Li et. al. [9] in an effort to overcome the limitations of melt derived BGs (synthesis at high temperature, lack of microporous structure,...

show abstract

Antioxidant mesoporous Ce-doped bioactive glass nanoparticles with anti-inflammatory and pro-osteogenic activities

Cited by 87 publications

References 84 publications

Tailoring Materials for Modulation of Macrophage Fate

Tailoring Materials for Modulation of Macrophage Fate

Combination of Selective Etching and Impregnation toward Hollow Mesoporous Bioactive Glass Nanoparticles

Effect of Sr, Zn, and Ce Substitution on the Properties of Bioactive Glasses

Contact Info

Product

Resources

About