Antioxidant monoammonium glycyrrhizinate alleviates damage from oxidative stress in perinatal cows

Zhang, Cai; Li, Chenxu; Shao, Qi; Meng, Sudan; Kong, Tao; Li, Yu

doi:10.1111/jpn.13764

Cited by 4 publications

(1 citation statement)

References 39 publications

(50 reference statements)

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“…Malondialdehyde (MDA), a major marker and product of lipid peroxidation, was measured to assess the oxidative status in vivo (Castillo et al, 2006;Tsuchiya et al, 2020). In addition, the antioxidants superoxide dismutase (SOD) and reduced glutathione (GSH) were analysed to evaluate their antioxidant capacities (Abd Ellah et al, 2009;Skaperda et al, 2021;Zhang et al, 2023). However, when the conventional method is used to separately evaluate oxidative stress values and antioxidant capacity, it is uncertain whether individuals with high oxidative stress values are truly in a state of oxidative stress (Lichtenberg et al, 2018), and the measurement is laborious.…”

Section: Introductionmentioning

confidence: 99%

Impact of redox status of donor cows before superovulation treatment on in vivo embryo production

Hashimoto,

Taniguchi,

Edo

et al. 2023

Arch. Anim. Breed.

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Abstract. This study investigated the relationship between oxidation and antioxidation parameters before superovulation (SOV) treatment and embryo recovery in donor cows. The relative redox status of the 61 donor cows was evaluated based on the median values of diacron-reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP) measurements (d-ROMs of 100 U.CARR; BAP of 2413 µmol L−1) before SOV treatment. Following this, the animals were divided into four groups: cows with low d-ROMs but high BAP were assigned to the “LH” group (n=11), cows with high d-ROMs and BAP were assigned to the “HH” group (n=20), cows with high d-ROMs but low BAP were assigned to the “HL” group (n=10), and cows with low d-ROMs and BAP were assigned to the “LL” group (n=20). Embryos were collected from superovulated cows 6 d after artificial insemination. The percentages of fertilised, transferable, and Code-1 embryos were significantly higher (P<0.05) in the HH group than those in the HL group. The HH group had the highest mean values for all embryo recovery results. Our results suggest that the redox status of donor cows before SOV treatment affects embryo recovery, as cows with high levels of both oxidative and antioxidative status have better embryo production.

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Section: Introductionmentioning

confidence: 99%

Impact of redox status of donor cows before superovulation treatment on in vivo embryo production

Hashimoto,

Taniguchi,

Edo

et al. 2023

Arch. Anim. Breed.

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Glycyrrhizin alleviates varicellovirus bovinealpha 1-induced oxidative stress, inflammation, and apoptosis in MDBK cells by inhibiting NF-κB/NLRP3 axis through the Nrf2 signalling pathway

Guo,

Wang,

Zhang

et al. 2023

Vet Res Commun

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Monoammonium glycyrrhizinate improves antioxidant capacity of calf intestinal epithelial cells exposed to heat stress in vitro

Wang

Meng

Wang

et al. 2023

Journal of Animal Science

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Dairy calves are highly susceptible to the negative effects of heat stress, which can cause organ hypoxia after blood redistribution, damage the intestinal barrier, and trigger intestinal oxidative stress. This study aimed to investigate the antioxidant effects of monoammonium glycyrrhizinate (MAG) on calf small intestinal epithelial cells under heat stress in vitro. Small intestinal epithelial cells were isolated from a 1-day-old healthy calf and purified by differential enzymatic detachment. The purified cells were divided into seven groups. The control group was cultured with DMEM/F-12 at 37℃ for 6 h, and the treatment groups were cultured with 0, 0.1, 0.25, 0.5, 1, or 5 μg/mL MAG at 42℃ for 6 h. Heat stress causes oxidative damage to cells. Adding MAG in the medium can significantly improve cell activity and reduce cellular oxidative stress. Monoammonium glycyrrhizinate significantly increased the total antioxidant capacity (T-AOC) and superoxide dismutase (SOD) activity caused by heat stress, and significantly decreased malondialdehyde (MDA) and nitric oxide (NO) levels. The MAG treatment also reduced lactate dehydrogenase (LDH) release, increased mitochondrial membrane potential (MMP), and decreased apoptosis under heat stress. MAG also upregulated the expression of the antioxidant-related genes, Nrf2 and GSTT1, in heat-stressed intestinal epithelial cells and significantly downregulated the expression of the heat shock response-related proteins, MAPK, HSP70, HSP90, and HSP27. From the above results, we conclude that 0.25 μg/mL MAG improves the capability of the antioxidant system in small intestinal epithelial cells to eliminate reactive oxygen species by activating antioxidant pathways, improving the oxidant/antioxidant balance, lowering excessive heat shock responses, and reducing intestinal oxidative stress.

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Antioxidant monoammonium glycyrrhizinate alleviates damage from oxidative stress in perinatal cows

Cited by 4 publications

References 39 publications

Impact of redox status of donor cows before superovulation treatment on in vivo embryo production

Impact of redox status of donor cows before superovulation treatment on in vivo embryo production

Glycyrrhizin alleviates varicellovirus bovinealpha 1-induced oxidative stress, inflammation, and apoptosis in MDBK cells by inhibiting NF-κB/NLRP3 axis through the Nrf2 signalling pathway

Monoammonium glycyrrhizinate improves antioxidant capacity of calf intestinal epithelial cells exposed to heat stress in vitro

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