Antioxidant N-acetylcysteine attenuates the acute liver injury caused by X-ray in mice

Liu, Yang; Zhang, Hong; Zhang, Luwei; QingMing, Zhou; Wang, Xiaohu; Long, Jing; Dong, Ting; Zhao, Weiping

doi:10.1016/j.ejphar.2007.07.026

Cited by 36 publications

(30 citation statements)

References 42 publications

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“…6A). Co‐administration of NAC, an antioxidant agent known to eliminate reactive oxygen species (ROS),13 significantly reduced the elevation of hepatic TGF‐β1 expression in mice fed the MCD diet for 1 week, 3 weeks, or 8 weeks, in comparison with each corresponding group administered vehicle (Fig. 6A).…”

Section: Resultsmentioning

confidence: 98%

Hepatic AdipoR2 signaling plays a protective role against progression of nonalcoholic steatohepatitis in mice†

et al. 2008

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Section: Resultsmentioning

confidence: 98%

Hepatic AdipoR2 signaling plays a protective role against progression of nonalcoholic steatohepatitis in mice†

et al. 2008

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“…The rationale for this injection schedule is also based on the result of previous studies in which radiation-protective agents are administered both before and after radiation exposure. 23, 24 …”

Section: Methodsmentioning

confidence: 99%

The purinergic P2Y14 receptor axis is a molecular determinant for organism survival under in utero radiation toxicity

Cho

Morrison

et al. 2013

Cell Death Dis

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In utero exposure of the embryo and fetus to radiation has been implicated in malformations or fetal death, and often produces lifelong health consequences such as cancers and mental retardation. Here we demonstrate that deletion of a G-protein-coupled purinergic receptor, P2Y14, confers potent resistance to in utero radiation. Intriguingly, a putative P2Y14 receptor ligand, UDP-glucose, phenocopies the effect of P2Y14 deficiency. These data indicate that P2Y14 is a receptor governing in utero tolerance to genotoxic stress that may be pharmacologically targeted to mitigate radiation toxicity in pregnancy.

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“…Sulfhydryl(thiol)-containing compounds such as GSH are widely known to protect against radiation. For example, N-acetylcysteine (NAC), which is a thiol-reducing agent, induces an increase of GSH in the liver and reduces liver damage after irradiation [7]. Promoting increases in the GSH content in intracellular metabolism is also important.…”

Section: Sulfur-related Regulatory Systems As An Intracellular Defensmentioning

confidence: 99%

Roles of Sulfur Metabolism and Rhodanese in Detoxification and Anti-Oxidative Stress Functions in the Liver: Responses to Radiation Exposure

Nakajima¹

2015

Med Sci Monit

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Organisms must confront various environmental stresses. The liver is central to protecting against such stresses in mammals, and it has many detoxification and anti-oxidative stress functions. Radiation is a source of oxidative stress and is known to affect the liver and induce anti-oxidative responses. The detoxification enzyme rhodanese, which is also called thiosulfate sulfurtransferase (TST), has been demonstrated to be induced in the liver in response to radiation. Cyanide detoxification is a function of the liver, and rhodanese is a key enzyme involved in sulfur metabolism in that detoxification. Though the anti-oxidative stress system in which sulfur molecules such as thiol compounds are involved has attracted attention as a defense against radiation, detoxification enzymes may have other roles in this defense. Understanding how these functions are affected by alterations of sulfur metabolism (including thiol compounds) after irradiation would help uncover their roles in defense against cancer and other deleterious health effects, as well as environmental stress responses. This article reviews the roles of sulfur-related metabolism in oxidative stress regulation and detoxification for recovery from liver damage after radiation exposure, with particular attention to recent findings of sulfur-related enzymes such as rhodanese, which is unique in sulfur metabolism.

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Antioxidant N-acetylcysteine attenuates the acute liver injury caused by X-ray in mice

Cited by 36 publications

References 42 publications

Hepatic AdipoR2 signaling plays a protective role against progression of nonalcoholic steatohepatitis in mice†

Hepatic AdipoR2 signaling plays a protective role against progression of nonalcoholic steatohepatitis in mice†

The purinergic P2Y14 receptor axis is a molecular determinant for organism survival under in utero radiation toxicity

Roles of Sulfur Metabolism and Rhodanese in Detoxification and Anti-Oxidative Stress Functions in the Liver: Responses to Radiation Exposure

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