Antioxidant nanozymes in kidney injury: mechanism and application

Wu, Jian; Shang, Hongjing; Zhang, An; He, Yadong; Tong, Yonghua; Huang, Qiu; Xiao, Lan; Chen, Zhiqiang; Tang, Kun

doi:10.1039/d3nr01954c

Nanoscale

2023

DOI: 10.1039/d3nr01954c

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Antioxidant nanozymes in kidney injury: mechanism and application

Jian Wu

Hongjing Shang

An Zhang

et al.

Abstract: Excessive production of reactive oxygen species (ROS) in the kidney is involved in the pathogenesis of kidney diseases, such as acute kidney injury (AKI) and diabetic kidney disease (DKD),...

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2024

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Cited by 5 publications

References 125 publications

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Neutrophil‐Mediated Nanozyme Delivery System for Acute Kidney Injury Therapy

Yang,

Du,

Gan

et al. 2024

Adv Healthcare Materials

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Reactive oxygen species (ROS) scavenging of nanozymes toward acute kidney injury (AKI) is a current promising strategy, however, the glomerular filtration barrier (GFB) limits their application for treating kidney related diseases. Here, a neutrophil‐mediated delivery system able to hijack neutrophil to transport nanozyme‐loaded cRGD‐liposomes to inflamed kidney for AKI treatment by cRGD targeting integrin αvβ1 is reported. The neutrophil‐mediated nanozyme delivery system demonstrated great antioxidant and anti‐apoptosis ability in HK‐2 and NRK‐52E cell lines. Moreover, in ischemia‐reperfusion (I/R) induced AKI mice, a single dose of LM@cRGD‐LPs 12 h post‐ischemia significantly reduces renal function indicators, alleviates renal pathological changes, and inhibits apoptosis of renal tubular cells and the expression of renal tubular injured marker, thus remarkably reducing the damage of AKI. Mechanistically, the treatment of LM@cRGD‐LPs markedly inhibits the process of Nrf2 to the nucleus and reduces the expression of the downstream HO‐1, achieves a 99.51% increase in renal tissue Nrf2 levels, and an 86.31% decrease in HO‐1 levels after LM@cRGD‐LPs treatment. In short, the strategy of neutrophil‐mediated nanozyme delivery system hold great promise as a potential therapy for AKI or other inflammatory diseases.

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Neutrophil‐Mediated Nanozyme Delivery System for Acute Kidney Injury Therapy

Yang,

Du,

Gan

et al. 2024

Adv Healthcare Materials

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Ultrasmall Black Phosphorus Quantum Dots with Robust Antioxidative Properties for Acute Kidney and Liver Injury Therapy

Zhang,

Han,

Zhao

et al. 2024

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Acute organ injuries, such as acute kidney injury (AKI) and acute liver injury (ALI), usually present high morbidity and mortality in patients. However, the current clinical treatments remain limited, especially the lack of effective drug‐based treatment. Since these acute injuries are often associated with reactive oxygen species (ROS) overproduction, it is a promising strategy to develop therapeutic agents with potent ROS scavenging ability and excellent biocompatibility for efficient antioxidation therapy. Black phosphorus quantum dots (BPQDs), low‐dimensional nanomaterials prepared through a straightforward one‐step method and capable of complete controllable biodegradation, offer significant potential. This study comprehensively explores the extensive free‐radical scavenging capabilities of BPQDs, underscoring their immense potential in treating ROS‐related organ injuries. BPQDs could simultaneously achieve radical scavenging of DPPH, ABTS·, OH·, and O2−· and exhibit excellent cytoprotective effects against ROS‐mediated damage even at extremely low dosages. Besides, the ultrasmall size of BPQDs (≈3‐5 nm) allows them to effectively penetrate the glomerular filtration barrier (≈6 nm), significantly improving the symptoms of AKI and ALI in vivo. The therapeutic efficacy and great biocompatibility of BPQDs facilitate the clinical management of ROS‐related diseases, which will broaden the applications of QDs in the field of biomedicine.

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Revolutionizing nanozyme technology with metal-organic frameworks: Classification, catalytic mechanisms, regulation and applications in biotechnology

Wang,

Yang,

Liu

et al. 2024

Chemical Engineering Journal

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Antioxidant nanozymes in kidney injury: mechanism and application

Abstract: Excessive production of reactive oxygen species (ROS) in the kidney is involved in the pathogenesis of kidney diseases, such as acute kidney injury (AKI) and diabetic kidney disease (DKD),...

Cited by 5 publications

References 125 publications

Neutrophil‐Mediated Nanozyme Delivery System for Acute Kidney Injury Therapy

Neutrophil‐Mediated Nanozyme Delivery System for Acute Kidney Injury Therapy

Ultrasmall Black Phosphorus Quantum Dots with Robust Antioxidative Properties for Acute Kidney and Liver Injury Therapy

Revolutionizing nanozyme technology with metal-organic frameworks: Classification, catalytic mechanisms, regulation and applications in biotechnology

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