Antioxidant/Oxidant Balance as a novel approach to evaluate the effect on serum of long-term intake of plant antioxidant-rich foods

Soccio, Mario; Laus, Maura N.; Alfarano, Michela; Dalfino, Giuseppe; Panunzio, Michele F.; Pastore, Donato

doi:10.1016/j.jff.2017.12.012

Cited by 20 publications

(20 citation statements)

References 38 publications

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“…Numerous reports have shown that fresh fruits and vegetables have excellent antioxidant constituents and thus they may confer protection against chronic diseases caused by oxidative stress, such as cardiovascular disorders and some kinds of cancer [6][7][8][9][10]. Phenolic and flavonoid compounds have been reported to exhibit antioxidant properties [11].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Antioxidant and Wound-Healing Properties of Extracts from Different Parts of Hylocereus polyrhizus

et al. 2019

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Hylocereus polyrhizus cultivation started in Taiwan around the 1980s. The pulp of the fruit is edible and contains small, black, and soft seeds. The peel of the fruits are covered with bracts. The H. polyrhizus fruit is known to be rich in nutrients and minerals. To evaluate the potential applications of the agricultural wastes of H. polyrhizus, the stem, peel, and flower of H. polyrhizus were extracted with solutions of ethanol and water mixed in different ratios. Data was collected for the H. polyrhizus extract including the yield of total phenolics, the total flavonoids, and antioxidant activity, as determined by the 2-2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radical scavenging assay. The protective effects of H. polyrhizus extract on DNA was investigated using an assay with the pUC19 plasmid. The cell proliferation and migration effects were evaluated in the NIH-3T3 fibroblast cell line. The greatest yield of extract from the stem of H. polyrhizus was 44.70 ± 1.77% which was obtained using 50% aqueous ethanol and the greatest yield of extract from the peel was 43.47% using distilled water. The stem extract, which was prepared with 95% aqueous ethanol, had the highest composition of phenolics and flavonoids as well as the best DPPH radical scavenging activity. The stem extract had excellent ABTS radical scavenging activity as well. The stem, peel, and flower extracts, which were prepared using 95% aqueous ethanol, showed excellent results in protecting themselves from DNA damage, similar to the effect of 0.3 mg/mL ferulic acid. None of the extracts were able to promote cell proliferation at concentrations of 250 μg/mL to 2,000 μg/mL in a 24 h period. The 1000 μg/mL stem and flower extracts in 95% aqueous ethanol promoted considerable cell migration after a 24 h period.

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Section: Introductionmentioning

confidence: 99%

Evaluation of the Antioxidant and Wound-Healing Properties of Extracts from Different Parts of Hylocereus polyrhizus

et al. 2019

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“…Both parameters of the redox balance were assessed together as the ratio of total antioxidant defenses and oxidants, namely, antioxidant oxidant balance (AOB), previously applied in Ciliberti et al (21), where it was demonstrated a reliable index for the evaluation of the effects of diet on OS activated by heat stress exposition in sheep. Moreover, in human studies, it was applied in order to evaluate the antioxidant status of serum (22,23) and after long-term intake of plant antioxidant-rich foods (24). An increase in the ratio indicates a lower risk for OS exposition due to a prompter antioxidant defense against pro-oxidant production.…”

Section: Determination Of Ros Production Total Antioxidant Capacitymentioning

confidence: 99%

Nexus Between Immune Responses and Oxidative Stress: The Role of Dietary Hydrolyzed Lignin in ex vivo Bovine Peripheral Blood Mononuclear Cell Response

et al. 2020

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The control of immune responses is particularly critical when an increase of oxidative stress occurs, causing an impairment of immune cell response and a condition of systemic inflammation, named oxinflammation. Nutritional strategies based on the use in the diet of phytochemicals extracted from plants, rich in antioxidants, could help restore the antioxidant/oxidant balance and obtain a modulation of immune response. Lignin represents a valuable resource of phenolic compounds, which are characterized by a corroborated antioxidant effect. To date, there are no studies reporting the effects of lignin in the diet on immune responses and oxidative stress in ruminants. The objective of the present experiment was the evaluation of the dietary inclusion of Pinus taeda hydrolyzed lignin on the ex vivo immune responses and oxidative stress biomarkers by peripheral blood mononuclear cells (PBMCs) isolated from beef steers. In order to test the effect during oxidative stress exposition, cells were treated with hydrogen peroxide (H 2 O 2). The proliferation test and the viability assay were carried out on cells, whereas, on supernatants, the cytokine profile and the oxidative stress biomarkers were evaluated. The dietary inclusion with P. taeda hydrolyzed lignin resulted in cytoprotection after H 2 O 2 exposition, increasing the number of viable monocytes and decreasing the reactive oxygen/nitrogen species production in supernatants. The cytokine profile indicated the modulatory role of hydrolyzed lignin on immune response, with a concomitant decrease of TNF-α and increase of IL-8 production, which are strictly connected with monocyte activation and antioxidant response pathway. These results demonstrated that hydrolyzed lignin may provide a modulation of oxidative stress and inflammatory response in PBMCs; thus, the P. taeda hydrolyzed lignin could be suggested as an innovative phytochemical in ruminant feed.

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“…Evidence has accumulated about significant inverse correlations between plant antioxidants intake and the risk for cardiovascular diseases, type 2 diabetes, hypercholesterolemia, some cancers, and other globally spreading chronic diseases (Albanese et al, 2018;Tang et al, 2017), as well as no recommended upper limits apply to the intake of antioxidants, for the purpose of health benefits. Indeed, a monotonic increase of the ratio of the antioxidant activity (AA) to the oxidant status in the human blood serum (serum antioxidant/oxidant balance), with the long-term intake of antioxidant bioactive compounds, was recently found, and related to a sort of homeostatic equilibrium (Laus et al, 2017;Soccio, Laus, Alfarano, et al, 2018). Lately, by means of a novel AA assay, more representative of the real human physiology, a very effective synergism was demonstrated among mixtures of food-grade extracts, as well as among hydrophilic, lipophilic and insoluble-bound phenolic extracts (Soccio, Laus, Flagella, et al, 2018).…”

Section: Hc-driven Exploitation Of Plant-based Foodmentioning

confidence: 99%

Novel Affordable, Reliable and Efficient Technologies to Help Addressing the Water-Energy-Food Nexus

Meneguzzo¹,

Zabini²,

Albanese³

et al. 2019

EJSD

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Improving the food system sustainability and security is becoming an urgent global challenge. In this regard, one of the most effective routes is the shift of the human diet toward healthier and more sustainable consumption, involving in particular the prevalence of plant-based raw food materials. Controlled hydrodynamic cavitation (HC) technologies could help considerably in this transition. HC techniques are gaining increased scientific interest, and are quickly spreading across a wide range of technical fields, recently showing surprising performances with biological raw materials related to the food, agricultural and forestry sectors and resources. HC processes enjoy recognized advantages in the acceleration of the processing steps of plant-based food, the extraction of valuable bioactive compounds, the reduction and the valorization of waste streams, as well as the superior efficiency in resource use, energy consumption, process yield, and exergy balance than competing processes. Thus, HC is very promising candidate to help addressing the water-energy-food nexus, and, ultimately, sustainability. Findings obtained from direct experimental trials and recent literature concerning the applications of HC to food processing, provide a strong basis for novel investigation aimed at standardization, starting from the identification of the most suitable devices and the optimal processing parameters, eventually oriented to further spreading of HC applications.

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Antioxidant/Oxidant Balance as a novel approach to evaluate the effect on serum of long-term intake of plant antioxidant-rich foods

Cited by 20 publications

References 38 publications

Evaluation of the Antioxidant and Wound-Healing Properties of Extracts from Different Parts of Hylocereus polyrhizus

Evaluation of the Antioxidant and Wound-Healing Properties of Extracts from Different Parts of Hylocereus polyrhizus

Nexus Between Immune Responses and Oxidative Stress: The Role of Dietary Hydrolyzed Lignin in ex vivo Bovine Peripheral Blood Mononuclear Cell Response

Novel Affordable, Reliable and Efficient Technologies to Help Addressing the Water-Energy-Food Nexus

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