Antioxidant parameters and lipid peroxidation in salivary glands of streptozotocin-induced diabetic rats

Alteration of Ca2+‐ATPase activity in the homogenate, plasma membrane and microsomes of the salivary glands of streptozotocin‐induced diabetic rats

“…[2][3][4][5][6] Experimental animal models of diabetes, induced either by alloxan or streptozotocin, have been used to study aspects of the pathophysiology of this disease. In salivary glands alterations in the glycolytic enzymes activities, 7,8 antioxidant parameters 9,10 of the salivary glands have been reported. It has been reported that a reduction in submandibular salivary flow rate of rats was associated with calcium signaling.…”

Aspirin prevents diabetic oxidative changes in rat lacrimal gland structure and function

“…Of interest, peroxidase activity in exocrine tissues was markedly increased by systemic hormone suppression, not only insulin as in the models of diabetes mellitus type 1, but also suppression of sex hormones by gonadectomy [2,[17][18][19].…”

“…In order to monitor these processes, antioxidant enzyme levels that scavenge ROS and/or metabolites of lipids, proteins, or DNA damage by oxidation are adopted as oxidative stress markers [20,21]. Among them, malonaldehyde (MDA), a marker of lipid peroxidation and peroxidase activity, has been used to evaluate the antioxidant defense competence [18,22].…”

Tear film and ocular surface changes in diabetes mellitus

“…They include similar impact on histology, function ad signaling mechanisms (58,61) . Evidences of oxidative stress secondary to hyperglicemia has been explored for a long time and was suggested to contribute to cell damage and exocrine gland dysfunction (28,(62)(63) . Hyperglycemia involves expression of the inflammatory cytokines of the innate immune system, as TNF-α and IL-1β, which are clearly involved in lacrimal gland impairment in other animal models (28,(64)(65) .…”