Antioxidant perturbations in the olfactory mucosa of alachlor-treated rats

Burman, Dawn M.; Shertzer, Howard G.; Senft, Albert P.; Dalton, Timothy P.; Genter, Mary Beth

doi:10.1016/s0006-2952(03)00475-1

Cited by 25 publications

(13 citation statements)

References 51 publications

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“…(Continued) TOXICOLOGIC PATHOLOGY DISCUSSION Recent results from our laboratory suggest that dysregulation of extracellular matrix genes and antioxidant perturbations may act together in the pathogenesis of alachlor-induced olfactory tumors. Biochemical studies from our laboratory confirm that alachlor and metolachlor induce antioxidant perturbations in target tissues for carcinogenicity induced by the respective compounds (Burman et al, 2003; also unpublished observations from Genter lab). Gene expression studies suggested that MMP-2 and MMP-9 were upregulated following short-term alachlor exposure, concomitant with upregulation of oxidative stress-related genes (Genter et al, 2002b).…”

Section: Mmps In Alachlor Olfactory Carcinogenesis 597supporting

confidence: 64%

Reduction of Alachlor-Induced Olfactory Mucosal Neoplasms by the Matrix Metalloproteinase Inhibitor Ro 28-2653

et al. 2005

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Chronic exposure to the chloracetanilide herbicide alachlor has been shown to cause olfactory mucosal neoplasms. Genomic analysis of olfactory mucosa from rats given alachlor (126 mg/kg/d) for from 1 day to 18 mo suggested that matrix metalloproteinases MMP-2 and MMP-9 were upregulated in the month following initiation of treatment. The present studies were designed to confirm this latter finding and to explore the potential role of MMPs in alachlor-induced olfactory carcinogenesis. Zymographic analysis of olfactory mucosal extracts confirmed that MMP-2 activity is higher in the olfactory mucosa of alachlor-treated rats. Therefore, rats were fed alachlor (126 mg/kg/d in the diet for 1 year) either with or without the MMP-2/MMP-9 inhibitor Ro 28-2653 (100 mg/kg daily by gavage for the first 2 months of alachlor treatment). The number of olfactory mucosal neoplasms was reduced by 25% after 1 year of alachlor treatment in rats that received both alachlor and Ro 28-2653. The morphology of alachlor-induced olfactory tumors was similar whether or not Ro 28-2653 had been given; the MMP inhibitor itself had no impact on olfactory mucosal histology. These data confirm that olfactory mucosal MMP-2 activity is increased following short-term alachlor exposure and show that administration of an MMP-2/9 inhibitor reduced the incidence of olfactory neoplasms in alachlor-treated rats, thereby implicating MMP-2 activity as a mediator of alachlor-induced carcinogenicity.

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Section: Mmps In Alachlor Olfactory Carcinogenesis 597supporting

confidence: 64%

Reduction of Alachlor-Induced Olfactory Mucosal Neoplasms by the Matrix Metalloproteinase Inhibitor Ro 28-2653

et al. 2005

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“…700μL sample, 150μL 85% H3PO4, 150μL 3% ferric ammonium sulfate were mixed and then 3 mL 0.4% 2, 2'-bipyridine was mixed to make the final volume of 4 mL at different intervals [21]. , and all binding energies were referenced to the C 1s peak at 284.6 eV of the surface adventitious carbon.…”

Section: Analysis Methodsmentioning

confidence: 99%

Ascorbic acid/Fe@Fe2O3: A highly efficient combined Fenton reagent to remove organic contaminants

Hou

Huang

et al. 2016

Journal of Hazardous Materials

214

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In this study, we demonstrate that the combination of ascorbic acid and Fe@Fe2O3 core-shell nanowires (AA/Fe@Fe2O3) offers a highly efficient Fenton reagent. This combined Fenton reagent exhibited extremely high activity on the decomposition of H2O2 to produce OH for the degradation of various organic contaminants, including rhodamine B, methylene blue, alachlor, atrazine, siduron, lincomycin, and chloroamphenicol. The contaminant degradation constants in the AA/Fe@Fe2O3/H2O2 Fenton systems were 38-53 times higher than those in the conventional homogeneous Fenton system (Fe(II)/H2O2) at pH 3.8. Moreover, the OH generation rate constant in the AA/Fe@Fe2O3/H2O2 Fenton system was 1-3 orders of magnitudes greater than those of heterogeneous Fenton systems developed with other iron-containing materials (α-FeOOH, α-Fe2O3, FeOCl, and so on). The high activity of AA/Fe@Fe2O3 was attributed to the effective Fe(III)/Fe(II) cycle and the iron-ascorbate complex formation to stabilize ferrous ions with desirable and steady concentrations. During the AA/Fe@Fe2O3/H2O2 Fenton process, ascorbic acid served as a reducing and complexing reagent, enabling the reuse of Fe@Fe2O3 nanowires. We systematically investigated the alachlor and ascorbic acid degradation and found that they could be effectively degraded in the AA/Fe@Fe2O3/H2O2 system, accompanying with 100% of dechlorination and 92% of denitrification. This study sheds light on the importance of Fe(III)/Fe(II) cycle for the design of high efficient Fenton system and provides an alternative pathway for the organic contaminants removal.

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“…AA concentration was measured by a modified previously described method [38]. The chlorine ions were detected by using an ion chromatograph (IC, Dionex ICS-900, Thermo, USA) equipped with an AS23 column.…”

Section: Methodsmentioning

confidence: 99%

Ascorbic acid induced atrazine degradation

Hou

Huang

et al. 2017

Journal of Hazardous Materials

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In this study, we systematically investigated the degradation efficiency and the degradation mechanism of atrazine in the presence of ascorbic acid at different pH values. Although atrazine could be degraded by ascorbic acid in a wide pH range from 4 to 12, its degradation under either acidic (pH≤4) or alkaline (pH≥12) condition was more efficient than under neutral condition (pH=7). This pH dependent atrazine degradation was related to the reactive characteristic of atrazine and the reductive activity of ascorbic acid. The ascorbic acid induced atrazine degradation pathways at different pH were investigated by comparing the atrazine degradation intermediates with liquid chromatography-mass spectrometry, high performance liquid chromatography and ion chromatography. It was found that more products were detected in presence of ascorbic acid at alkaline condition. The appearance of chloride ions confirmed the dechlorination of atrazine by ascorbic acid in the absence of molecular oxygen, while its dechlorination efficiency reached highest at pH 12. These results can shed light on the application of AA for the organic pollutant remediation.

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Antioxidant perturbations in the olfactory mucosa of alachlor-treated rats

Cited by 25 publications

References 51 publications

Reduction of Alachlor-Induced Olfactory Mucosal Neoplasms by the Matrix Metalloproteinase Inhibitor Ro 28-2653

Reduction of Alachlor-Induced Olfactory Mucosal Neoplasms by the Matrix Metalloproteinase Inhibitor Ro 28-2653

Ascorbic acid/Fe@Fe2O3: A highly efficient combined Fenton reagent to remove organic contaminants

Ascorbic acid induced atrazine degradation

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