Antioxidant potential in non-extractable fractions of dried persimmon (Diospyros kaki Thunb.)

Matsumura, Yoshiaki; Ito, Toshihiro; Yano, Hisakazu; Kita, Eiji; Mikasa, Keiichi; Okada, Masatoshi; Furutani, Azusa; Murono, Yuka; Shibata, Mitsuru; Nishii, Yasue; Kayano, Shin-ichi

doi:10.1016/j.foodchem.2016.01.112

Cited by 40 publications

(25 citation statements)

References 30 publications

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“…In this way, the SPP fraction value is within the range expected for the sample. In contrast, there are no previous reports in the literature regarding the insoluble-bound polyphenol content of guarana powder, but similar investigations of green tea and dried persimmon resulted in the IBPPs contributing to 19 and 4% to the TPC, respectively [47,48], while the IBPP fraction of the guarana powder sample contributed 6% to the total value, although the hydrolyzation may impact the screening results. Different extraction methods, such as enzyme-assisted or fermentation, may be used in the future in order to release a higher proportion of the insoluble-bound polyphenols from the matrix [49].…”

Section: Screeningmentioning

confidence: 67%

Insoluble-Bound Polyphenols Released from Guarana Powder: Inhibition of Alpha-Glucosidase and Proanthocyanidin Profile

Acdc

Soares

et al. 2020

Molecules

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The Brazilian Food Supplement Law recently recognized that guarana (Paullinia cupana) contains bioactive substances, hence supporting its role as a functional food ingredient. The health benefits of guarana are associated, at least in part, to its phenolic compounds. However, to the best of our knowledge, there is no literature addressing the presence of phenolic compounds in the fraction containing insoluble-bound compounds and its contribution in terms of alpha-glucosidase inhibition. The concentration of phenolic extracts released from the insoluble-bound fraction required to inhibit 50% of alpha-glucosidase (IC50) activity was 5.8-fold lower than that present in the soluble counterpart. Both fractions exhibited a mixed inhibition mode. Fourteen proanthocyanidins (dimers to tetramers) present in the insoluble-bound fraction were tentatively identified by MALDi-TOF-MS. Future studies aiming at increasing the concentration of the soluble counterpart are deemed necessary. The results presented here enhance the phenolic database of guarana and have a practical impact on the procurement of nutraceuticals and functional ingredients related to the prevention and/or management of type 2 diabetes. The Brazilian normative on food supplements has been recently revised. This study lends support to the future inclusion of guarana powder in the list of sources of proanthocyanidins for the industry of food supplements.

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Section: Screeningmentioning

confidence: 67%

Insoluble-Bound Polyphenols Released from Guarana Powder: Inhibition of Alpha-Glucosidase and Proanthocyanidin Profile

Acdc

Soares

et al. 2020

Molecules

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“…Interestingly, soluble tannin powder had no significant effect against MAC in vitro , which suggests that it is necessary to hydrolyze soluble tannin into small molecules for its anti-bacteriostatic activity. In a previous study, we investigated the plasma ORAC value of animals fed a tannin-containing diet, and demonstrated that the plasma ORAC value of animals fed tannin was higher than the control diet group [ 15 ]. To increase plasma ORAC values, decomposition and absorption of tannin are required.…”

Section: Discussionmentioning

confidence: 99%

“…We have demonstrated that the plasma oxygen radical absorbance capacity (ORAC) value of rats fed the non-extractable fraction of persimmon fruit, which contains condensed tannin, was higher than the control diet group. This suggests that condensed tannin may be fermented by enteric bacteria, followed by absorption as smaller antioxidant molecules in vivo [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Persimmon-derived tannin has bacteriostatic and anti-inflammatory activity in a murine model of Mycobacterium avium complex (MAC) disease

et al. 2017

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Nontuberculous mycobacteria (NTM), including Mycobacterium avium complex (MAC), cause opportunistic chronic pulmonary infections. Notably, MAC susceptibility is regulated by various factors, including the host immune system. Persimmon (Ebenaceae Diospyros kaki Thunb.) tannin is a condensed tannin composed of a polymer of catechin groups. It is well known that condensed tannins have high antioxidant activity and bacteriostatic properties. However, it is hypothesized that condensed tannins might need to be digested and/or fermented into smaller molecules in vivo prior to being absorbed into the body to perform beneficial functions. In this study, we evaluated the effects of soluble persimmon-derived tannins on opportunistic MAC disease. Soluble tannins were hydrolyzed and evaluated by the oxygen radical absorbance capacity (ORAC) method. The ORAC value of soluble tannin hydrolysate was approximately five times greater than that of soluble tannin powder. In addition, soluble tannin hydrolysate exhibited high bacteriostatic activity against MAC in vitro. Furthermore, in an in vivo study, MAC infected mice fed a soluble tannin-containing diet showed significantly higher anti-bacterial activity against MAC and less pulmonary granuloma formation compared with those fed a control diet. Tumor necrosis factor α and inducible nitric oxide synthase levels were significantly lower in lungs of the soluble tannin diet group compared with the control diet group. Moreover, proinflammatory cytokines induced by MAC stimulation of bone marrow-derived macrophages were significantly decreased by addition of soluble tannin hydrolysate. These data suggest that soluble tannin from persimmons might attenuate the pathogenesis of pulmonary NTM infection.

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“…The extraction procedure of NEP from residue was according to the method described previously (Matsumura et al, 2016) with a slight modification.…”

Section: Preparation Of Nepmentioning

confidence: 99%

Antioxidant and α‐glucosidase inhibitory capacity of nonextractable polyphenols in Mopan persimmon

Zhou

Mao

et al. 2020

Food Science & Nutrition

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Antioxidant potential in non-extractable fractions of dried persimmon (Diospyros kaki Thunb.)

Cited by 40 publications

References 30 publications

Insoluble-Bound Polyphenols Released from Guarana Powder: Inhibition of Alpha-Glucosidase and Proanthocyanidin Profile

Insoluble-Bound Polyphenols Released from Guarana Powder: Inhibition of Alpha-Glucosidase and Proanthocyanidin Profile

Persimmon-derived tannin has bacteriostatic and anti-inflammatory activity in a murine model of Mycobacterium avium complex (MAC) disease

Antioxidant and α‐glucosidase inhibitory capacity of nonextractable polyphenols in Mopan persimmon

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