Antioxidant Potential of Curcumin—A Meta-Analysis of Randomized Clinical Trials

Jakubczyk, Karolina; Drużga, Aleksandra; Janda, Katarzyna; Skonieczna-Żydecka, Karolina

doi:10.3390/antiox9111092

Cited by 188 publications

(113 citation statements)

References 45 publications

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“…Curcumin is well documented due to potent pharmacological activities including antioxidant, anti-inflammatory, anti-microbial, anti-mutagenic anti-angiogenic, and antidiabetic [59,60]. Additionally, curcumin is useful to treat irritable bowel syndrome due to its ability to modulate the gut microbiota [61]. Hydroxytyrosol (compound 69) was observed in negative mode at m/z 153.0553, which was further identified through MS 2 [63].…”

Section: Other Polyphenolsmentioning

confidence: 99%

Comprehensive Profiling of Most Widely Used Spices for Their Phenolic Compounds through LC-ESI-QTOF-MS2 and Their Antioxidant Potential

et al. 2021

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Spices have long been used to improve food flavor, due to their appealing fragrance and sensory attributes. Nowadays, spices-based bioactives, particularly phenolic compounds, have gained attention due to their wide range of significant effects in biological systems. The present study was conducted to characterize the 12 widely used spices (allspice, black cardamom, black cumin, black pepper, cardamom, cinnamon, clove, cumin, fennel, nutmeg, star-anise, and turmeric) for their phenolics with the liquid chromatography-electrospray ionization quadrupole time-of-flight mass spectrometry (LC-ESI-QTOF-MS2), polyphenols estimation, and their antioxidant potential. Total phenolics, total flavonoids, and total tannin content and their antioxidant activities were estimated in all spices. Clove and allspice had the highest value of total polyphenol content (215.14 and 40.49 mg gallic acid equivalent (GAE) per g of sample), while clove and turmeric had the highest total flavonoids (5.59 mg quercetin equivalent (QE) per g of sample) and total tannin contents (23.58 mg catechin equivalent (CE) per g of sample), respectively. On the other hand, black cumin and black pepper had the highest phosphomolybdate activity (15.61 and 15.43 mg ascorbic acid equivalent (AAE) per g of sample), while clove was almost identified with highest free radical scavenging capacity. A positive correlation was observed among phenolic compounds and antioxidant activities. In this quest, a total of 79 phenolic compounds were tentatively characterized by using LC-ESI-QTOF-MS2 including 26 phenolic acids, 33 flavonoids, 16 other polyphenols, and 4 lignans. The high-performance liquid chromatography coupled with photodiode array detector (HPLC-PDA) quantification of phenolic compounds exhibited higher phenolic acids. These results provided us some valuable information that spices have powerful antioxidant potential that can be further used in human food and animal feed as a supplement for different health promoting applications.

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Section: Other Polyphenolsmentioning

confidence: 99%

Comprehensive Profiling of Most Widely Used Spices for Their Phenolic Compounds through LC-ESI-QTOF-MS2 and Their Antioxidant Potential

et al. 2021

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“…Aside bioavailability, the varied duration of these studies can account for the distinct findings between the two trials. Nevertheless, a recent meta-analysis further confirmed the prooxidant and anti-peroxidative effect of curcumin across four randomized clinical trials (67).…”

Section: Antidiabetic Property Of Curcuminmentioning

confidence: 95%

Exploring the Potentials of Curcumin as a Single Agent in the Management of Metabolic Syndrome

Ibrahim¹,

Jega²

2020

ABMS

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Despite the rising global prevalence of metabolic syndrome (MetS), a collection of cardio-metabolic risk factors that predispose individuals who have them to the development of cardiovascular disease and type 2 diabetes mellitus, its management is still based on the treatment of the different risk factors. There is currently no single therapeutic agent that is used for the concurrent treatment of all the risk factors. The current push for the use of natural products in the management of diseases has inspired research into the beneficial effects of many plant products. Curcumin is a bioactive curcuminoid from the rhizomes of turmeric (Curcuma longa) that has been shown to possess anti-obesity, anti-diabetic, hypolipidaemic and anti-hypertensive properties amongst others. These properties are closely linked to the ability of curcumin to act on several molecular targets in the body to bring about its effects. Considering these anti-MetS activities of curcumin, it holds promise as a potential therapeutic agent for the holistic treatment of the syndrome.

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“…This has led to numerous preclinical and clinical trials to show its efficacy. Indeed, curcumin supplementation in humans has been shown to have significant antioxidant capacity and a tendency to decrease malondialdehyde (MDA) concentrations [40].…”

Section: Antioxidantmentioning

confidence: 99%

Metal–Curcumin Complexes in Therapeutics: An Approach to Enhance Pharmacological Effects of Curcumin

Prasad

DuBourdieu²,

Srivastava³

et al. 2021

IJMS

127

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Curcumin, an active component of the rhizome turmeric, has gained much attention as a plant-based compound with pleiotropic pharmacological properties. It possesses anti-inflammatory, antioxidant, hypoglycemic, antimicrobial, neuroprotective, and immunomodulatory activities. However, the health-promoting utility of curcumin is constrained due to its hydrophobic nature, water insolubility, poor bioavailability, rapid metabolism, and systemic elimination. Therefore, an innovative stride was taken, and complexes of metals with curcumin have been synthesized. Curcumin usually reacts with metals through the β-diketone moiety to generate metal–curcumin complexes. It is well established that curcumin strongly chelates several metal ions, including boron, cobalt, copper, gallium, gadolinium, gold, lanthanum, manganese, nickel, iron, palladium, platinum, ruthenium, silver, vanadium, and zinc. In this review, the pharmacological, chemopreventive, and therapeutic activities of metal–curcumin complexes are discussed. Metal–curcumin complexes increase the solubility, cellular uptake, and bioavailability and improve the antioxidant, anti-inflammatory, antimicrobial, and antiviral effects of curcumin. Metal–curcumin complexes have also demonstrated efficacy against various chronic diseases, including cancer, arthritis, osteoporosis, and neurological disorders such as Alzheimer’s disease. These biological activities of metal–curcumin complexes were associated with the modulation of inflammatory mediators, transcription factors, protein kinases, antiapoptotic proteins, lipid peroxidation, and antioxidant enzymes. In addition, metal–curcumin complexes have shown usefulness in biological imaging and radioimaging. The future use of metal–curcumin complexes may represent a new approach in the prevention and treatment of chronic diseases.

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Antioxidant Potential of Curcumin—A Meta-Analysis of Randomized Clinical Trials

Cited by 188 publications

References 45 publications

Comprehensive Profiling of Most Widely Used Spices for Their Phenolic Compounds through LC-ESI-QTOF-MS2 and Their Antioxidant Potential

Comprehensive Profiling of Most Widely Used Spices for Their Phenolic Compounds through LC-ESI-QTOF-MS2 and Their Antioxidant Potential

Exploring the Potentials of Curcumin as a Single Agent in the Management of Metabolic Syndrome

Metal–Curcumin Complexes in Therapeutics: An Approach to Enhance Pharmacological Effects of Curcumin

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