Antioxidant potential of family Cucurbitaceae with special emphasis on <i>Cucurbita</i> genus: A key to alleviate oxidative stress‐mediated disorders

Salehi, Bahare; Quispe, Cristina; Sharifi‐Rad, Javad; Giri, Lalit; Suyal, Renu; Jugran, Arun K.; Zucca, Paolo; Rescigno, Antonio; Peddio, Stefania; Bobiş, Otilia; Moise, Adela; Leyva-Gómez, Gerardo; Prado-Audelo, María Luisa Del; Cortés, Hernán; Martorell, Miquel; Cruz‐Martins, Natália; Kumar, Manoj; Zam, Wissam

doi:10.1002/ptr.7045

Cited by 26 publications

(9 citation statements)

References 167 publications

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“…Meanwhile, Cucurbitaceous vegetables play an enormous role in alleviating oxidative stress-mediated disorders, which are attributed to their nutrient composition: cucurbitacins, carotenoids, phytosterols, antioxidative polyphenols and polyunsaturated fatty acids, etc. [182]. Cucurbitacin I upregulated the expression of NRF-1, PPARα, ERRα, and PGC-1-β to protect H 2 O 2 -treated H9c2 from mitochondrial dysfunctioninduced oxidative stress [183].…”

Section: Cucurbitaceous Vegetablesmentioning

confidence: 99%

Roles of Reactive Oxygen Species in Vascular Complications of Diabetes: Therapeutic Properties of Medicinal Plants and Food

Tan

Cheong

Cheang

2022

Oxygen

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The rising prevalence of chronic metabolic disorders, such as obesity and type 2 diabetes, most notably associated with cardiovascular diseases, has emerged as a major global health concern. Reactive oxygen species (ROS) play physiological functions by maintaining normal cellular redox signaling. By contrast, a disturbed balance occurring between ROS production and detoxification of reactive intermediates results in excessive oxidative stress. Oxidative stress is a critical mediator of endothelial dysfunction in obesity and diabetes. Under a hyperglycemic condition, the antioxidant enzymes are downregulated, resulting in an increased generation of ROS. Increases in ROS lead to impairment of endothelium-dependent vasodilatations by reducing NO bioavailability. Chronic treatments with antioxidants were reported to prevent the development of endothelial dysfunction in diabetic patients and animals; however, the beneficial effects of antioxidant treatment in combating vascular complications in diabetes remain controversial as antioxidants do not always reverse endothelial dysfunction in clinical settings. In this review, we summarize the latest progress in research focused on the role of ROS in vascular complications of diabetes and the antioxidant properties of bioactive compounds from medicinal plants and food in animal experiments and clinical studies to provide insights for the development of therapeutic strategies.

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Section: Cucurbitaceous Vegetablesmentioning

confidence: 99%

Roles of Reactive Oxygen Species in Vascular Complications of Diabetes: Therapeutic Properties of Medicinal Plants and Food

Tan

Cheong

Cheang

2022

Oxygen

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“…Melon (Cucumis melo L.) is an important cash crop that belongs to the family Cucurbitaceae, which contains 1,000 species such as watermelon, cucumber, squash, and pumpkins (Salehi et al, 2021). It is widely cultivated all over the world from temperate, tropical, and subtropical climates to arid regions (FAO, 2017).…”

Section: Introductionmentioning

confidence: 99%

Fosthiazate inhibits root-knot disease and alters rhizosphere microbiome of Cucumis melo var. saccharinus

et al. 2023

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Root-knot nematodes especially Meloidogyne spp. are considered as most destructive obligate parasites that substantially reduce crop yield and quality. Fosthiazate is an efficient organothiophosphate chemical with nematicidal activity against Meloidogyne spp. The present study aimed to analyze the efficacy of fosthiazate against root-knot disease in Cucumis melo var. saccharinus and its potential effects on rhizosphere microbiome and metabolites. The fosthiazate (40%) was applied two times by spraying on the day of transplanting and during the pollination period (after 31 days). Samples from treatment (fosthiazate 40%: MF) and control groups (untreated plants; MCK) were analysed through metagenomic and metabolomic profiling of rhizospheres. Results revealed that root-knot index of the MF group (9.26 ± 1.28) was significantly (p < 0.05) lower than the MCK group (22.06 ± 0.71) with a control effect of 57.85% after 31 days of the first spray, whereas fosthiazate efficacy reduced to 31.87% after 38 days of second application with significantly (p < 0.05) different root-knot index values (MF: 56 ± 1.43 and; MCK: 82.26 ± 3.87). However, Cucumis melo var. saccharinus fruit yield in both groups (MCK: 21.1 ± 0.9 and MF: 21.53 ± 0.85) showed no differences (p > 0.05). Metagenomic profiling revealed Proteobacteria, Acidobacteriota, and Firmicutes as predominant phyla and Bacillus, Sphingomonas, and Acidibacter as predominant genera in rhizosphere soil samples of both MF and MCK groups. Further, a t-test revealed higher differential enrichment of Firmicutes at phylum level and Bacillus at genus level in MF than MCK. Metabolomic profiling of rhizospheric soil revealed a total of six differential metabolites (p < 0.05), four of them (Sucrose, Hexaonic acid 1, (Z)-9-Octadecenamide 1, and Hexadecanamide) were up-regulated in MF group, whereas two of them (2,3,4-Trihydroxy-3-(Hydroxymethyl) Butanol and Sulfurous acid, 2, ethylhexylundecyl ester) were down-regulated in CK group. Our study concluded that fosthiazate exhibits a better control over the rook-knot disease in the short term and resulted in trackable changes in rhizosphere microbiome and metabolome.

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“…The vegetables include cucumber (Cucumis sativus), zucchini (Cucurbita pepo), pumpkin (Cucurbita maxima, C. moschata, and Cucurbita argyrosperma), wax gourd (Benincasa hispida), bottle gourd (Lagenaria siceraria), bitter gourd (Momordica charantia), ridge gourd (Luffa acutangula), sponge gourd (Luffa cylindrica), chayote (Sechium edule), and snake gourd (Trichosanthes anguina), and the fruits include melon (Cucumis melo), horned cucumber (Cucumis metuliferus), watermelon (Citrullus lanatus), and luo-hanguo (Siraitia grosvenorii). Among these, the bitter gourd (M. charantia) and luo-hanguo (S. grosvenorii) both have significant culinary and medicinal uses, while snake gourds (Trichosanthes anguina ) and bottle gourds (Trichosanthes anguina) can be utilized both as food and decorative items [3].…”

Section: Introductionmentioning

confidence: 99%

Overview of Cucurbitaceae Families

Yiblet

2023

Biological and Abiotic Stress in Cucurbitaceae Crops

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There are more than 960 species of crops in the Cucurbitaceae family. Since ancient times, members of this family of vegetables have been utilized as both food and medical purposes. Pumpkin and cucumber are the two most recognizable cucurbits. They are indigenous to the majority of the world's nations, particularly those in the tropics, where they are grown in every nation, state, and province. The Cucurbitaceae family includes numerous significant food plants including melon, pumpkin, squash, and cucumber as well as plants that can be used to produce useful goods like bottle gourds, loofah, and ornamental gourds. Due to the presence of cucurbitacins, some species, such as bitter melon, cucumber and musk melon are thought to have medicinal benefits. Cucurbit plants are abundant in phytochemicals, terpenoids, saponins, and carotenoids.

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Antioxidant potential of family Cucurbitaceae with special emphasis on Cucurbita genus: A key to alleviate oxidative stress‐mediated disorders

Cited by 26 publications

References 167 publications

Roles of Reactive Oxygen Species in Vascular Complications of Diabetes: Therapeutic Properties of Medicinal Plants and Food

Roles of Reactive Oxygen Species in Vascular Complications of Diabetes: Therapeutic Properties of Medicinal Plants and Food

Fosthiazate inhibits root-knot disease and alters rhizosphere microbiome of Cucumis melo var. saccharinus

Overview of Cucurbitaceae Families

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