Antioxidant potential of flavonoid glycosides from Manniophyton fulvum Müll. (Euphorbiaceae): Identification and molecular modeling

Babiaka, Smith B.; Rossiana, Nia; Abuga, Kennedy O.; Mbah, James A.; Nziko, Vincent de Paul N.; Paper, D.; Ntie‐Kang, Fidele

doi:10.1016/j.sciaf.2020.e00423

Cited by 15 publications

(13 citation statements)

References 13 publications

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“…Some of the main potential health benefits of phenolics and flavonoids are their antioxidant activities [ 47 ]. Among the ingredients, flavonoid-7-O-glycosides, anthocyanidin-3-O-glycosides, traumatic acid, p -coumaric acid, ferulic acid, and kaempferol-3-O-alpha-L-rhamnoside are flavonoids and phenolic compounds that possess strong 2,2-diphenyl-1-picrylhydrazyl ( DPPH) scavenging activity [ 48 ]. Phlorizin is a phenylpropanoid ingredient of MDFE that possesses antioxidant potential [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

Methanolic Phoenix dactylifera L. Extract Ameliorates Cisplatin-Induced Hepatic Injury in Male Rats

El-Hak

Mahmoud²,

Ahmed

et al. 2022

Nutrients

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This study investigated the ameliorative potential of methanolic date flesh extract (MDFE) against cisplatin-induced hepatic injury. Twenty male rats (weighing 180–200 g) were allocated into four groups: control; date flesh (DF) group (oral 600 mg/kg MDFE for 21 days); Cis group (7.5 mg/kg i.p. at day 16); and date flesh/cisplatin (DF/Cis) group (oral 600 mg/kg MDFE for 21 days and 7.5 mg/kg i.p. at day 16). Hepatic biochemical parameters in sera, and inflammatory and oxidant/antioxidant hepatic biomarkers were estimated. Hepatic histological changes and the immunohistochemistry of cyclooxygenase-2 (COX-2), nuclear factor kappa B (NF-κB), and alpha smooth muscle actin (α-SMA) were assessed. Pretreatment with MDFE decreased Cis-triggered liver biochemical parameters, oxidative stress, inflammatory biomarkers, and histological damage. Moreover, MDFE treatment reduced Cis-induced hepatic NF-κB, COX-2, and α-SMA protein expression. MDFE exerted a hepatoprotective effect when used concomitantly with Cis. Its effect was mediated via its antioxidant and anti-inflammatory ingredients.

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Section: Discussionmentioning

confidence: 99%

Methanolic Phoenix dactylifera L. Extract Ameliorates Cisplatin-Induced Hepatic Injury in Male Rats

El-Hak

Mahmoud²,

Ahmed

et al. 2022

Nutrients

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“…One would wonder why such unusual basis sets as Ahlrich’s or Dunning’s, or methods such as TPSSh or WB97, were chosen when Pople’s [ 53 , 54 , 55 ], particularly when combined with Minnesota’s functionals [ 26 , 56 , 57 , 58 , 59 ], are leading the way? At the time of writing this paper, we were barely able to find articles that used def2– [ 60 ] or (aug–)cc–pVXZ [ 61 , 62 , 63 ] basis sets in their studies on antioxidative activity. A similar situation occurred in the case of functionals where, with a few exceptions, the bulk of papers used B3LYP and Minnesota functionals.…”

Section: Methodsmentioning

confidence: 99%

A Statistically Supported Antioxidant Activity DFT Benchmark—The Effects of Hartree–Fock Exchange and Basis Set Selection on Accuracy and Resources Uptake

2021

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Polyphenolic compounds are now widely studied using computational chemistry approaches, the most popular of which is Density Functional Theory. To ease this process, it is critical to identify the optimal level of theory in terms of both accuracy and resource usage—a challenge we tackle in this study. Eleven DFT functionals with varied Hartree–Fock exchange values, both global and range-separated hybrids, were combined with 14 differently augmented basis sets to calculate the reactivity indices of caffeic acid, a phenolic acid representative, and compare them to experimental data or a high-level of theory outcome. Aside from the main course, a validation of the widely used Janak’s theorem in the establishment of vertical ionization potential and vertical electron affinity was evaluated. To investigate what influences the values of the properties under consideration, linear regression models were developed and thoroughly discussed. The results were utilized to compute the scores, which let us determine the best and worst combinations and make broad suggestions on the final option. The study demonstrates that M06–2X/6–311G(d,p) is the best fit for such research, and, curiously, it is not necessarily essential to include a diffuse function to produce satisfactory results.

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“…Specially, kaempferol, quercetin and myricetin, both aglycones and glycosides, are potent natural antioxidants due to the presence of catechol moiety in ring B (quercetin), the presence of the 3-hydroxyl and 5-hydroxyl groups and the additional hydroxyl group in ring B (pyrogallol group) which seems to enhance further the antioxidant capacity (myricetin). 15,[20][21][22][23]…”

Section: Evaluation Of Antiradical Activitymentioning

confidence: 99%

Identification and Characterization of Bauhinia Species by Spectroscopic and Spectrometric Fingerprints

Pianoski¹,

Turco²,

Soares³

et al. 2020

Rev. Virtual Quim.

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Resumo: Algumas espécies de plantas do gênero Bauhinia são plantas medicinais com relevantes propriedades diuréticas, digestivas, anti-inflamatórias, analgésicas, sendo popularmente usadas no tratamento da hipertensão e do diabetes. As plantas deste gênero são conhecidas como "pata-de-vaca" devido ao formato de suas folhas; essa similaridade morfológica entre espécies e/ou subespécies torna sua diferenciação taxonômica um desafio. Buscando uma ferramenta auxiliar para discriminar espécies de Bauhinia, as impressões digitais espectroscópicas e espectrométricas dos extratos das folhas foram comparadas usando a análise de componentes principais (PCA). As amostras foram diferenciadas de acordo com o tipo (comercial ou não comercial), região de origem e espécie. A análise indicou que existem diferenças de perfil químico entre as amostras comerciais e não comerciais possivelmente originadas pela mistura de diferentes espécies de Bauhinia nas amostras comerciais. Desta forma, a PCA é uma ferramenta auxiliar na autenticação de amostras comerciais e não comerciais, rastreamento de origem e classificação taxonômica. Além disso, a atividade antirradicalar foi estatisticamente superior para amostras não comerciais (p<0,05), sugerindo que essa atividade diminui durante o armazenamento na prateleira. Some species of plants of the genus Bauhinia are medicinal plants with relevant pharmaceutical properties such as diuretic, digestive, anti-inflammatory, analgesic and are popularly used to treat hypertension and diabetes. They are widely known as "cow's foot" ("pata-de-vaca") due to the shape of their leaves; this morphological similarity among species and/or subspecies makes their taxonomic differentiation a challenge. Seeking for an auxiliary tool to discriminate Bauhinia species, spectroscopic and spectrometric fingerprints of extracts of Bauhinia leaves were compared using principal component analysis (PCA). Samples were distinguished according to their type (commercial or non-commercial), geographic origin, and specie. Multivariate data analysis indicated that there are differences between the chemical profile of commercial and non-commercial samples possibly due to the mixture of different species of Bauhinia in commercial samples. Thus, PCA may help to authenticate commercial and non-commercial samples, to trace their origin and indicate taxonomic classification. Additionally, the antiradical activity was statistically higher for non-commercial samples (p<0.05), suggesting that this activity diminishes during shelf storage.

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Antioxidant potential of flavonoid glycosides from Manniophyton fulvum Müll. (Euphorbiaceae): Identification and molecular modeling

Cited by 15 publications

References 13 publications

Methanolic Phoenix dactylifera L. Extract Ameliorates Cisplatin-Induced Hepatic Injury in Male Rats

Methanolic Phoenix dactylifera L. Extract Ameliorates Cisplatin-Induced Hepatic Injury in Male Rats

A Statistically Supported Antioxidant Activity DFT Benchmark—The Effects of Hartree–Fock Exchange and Basis Set Selection on Accuracy and Resources Uptake

Identification and Characterization of Bauhinia Species by Spectroscopic and Spectrometric Fingerprints

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