Antioxidant potential of  Himanthalia elongata  for protection against ischemia-reperfusion injury in the small bowel

Belda-Antolí, Mariola; Padrón-Sanz, Carolina; Cejalvo‐Lapeña, Dolores; Prieto‐Moure, Beatriz; Lloris-Cejalvo, José Miguel; Lloris‐Carsí, José Miguel

doi:10.1016/j.surg.2017.04.017

Cited by 10 publications

(10 citation statements)

References 35 publications

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“…In particular, cashew nuts have elevated nutritional importance: they can modulate risk of cardiovascular issues, metabolic syndrome [ 21 ], chronic inflammatory bowel disorders [ 15 ], and painful degenerative joint disease [ 22 ]. The positive effects of natural antioxidant compound such as bergamot juice [ 23 ], glycyrrhizin [ 24 ], green tea [ 25 ], Himanthalia elongata [ 26 ], thymoquinone, and melatonin [ 27 ] have been also described. Accordingly, our study evaluated the effect of the oral treatment of cashew nuts from Coted’Ivoire in an experimental rat model of gut ischemia/reperfusion injury.…”

Section: Introductionmentioning

confidence: 99%

Consumption of Anacardium occidentale L. (Cashew Nuts) Inhibits Oxidative Stress through Modulation of the Nrf2/HO−1 and NF-kB Pathways

et al. 2020

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Ischemia/reperfusion injury is a severe disorder associated with a high mortality. Several antioxidant and pharmacological properties of cashew nuts (Anacardium occidentale L.) and its metabolites from different countries have recently been described. It is a medicinal plant with important therapeutic effects. This study aimed to verify the effect of an oral administration of cashew nuts in a rat model of ischemia/reperfusion (I/R). Adult male rats were subjected to intestinal I/R injury by clamping the superior mesenteric artery for 30 min and then allowing animals to 1 h of reperfusion. Rats subjected to I/R of the gut showed a significant increase in different biochemical markers. In particular, we evaluated lipid peroxidation, tissue myeloperoxidase activity, protein carbonyl content, reactive oxygen species generation and decreased antioxidant enzyme activities. Western blot analysis showed the activation of the NRF2 and NF-kB pathways. Increased immunoreactivity to nitrotyrosine, PARP, P-selectin, and ICAM-1 was observed in the ileum of rats subjected to I/R. Administration of cashew nuts (100 mg/kg) significantly reduced the mortality rate, the fall in arterial blood pressure, and oxidative stress and restored the antioxidant enzyme activities by a mechanism involving both NRF2 and NF-kB pathways. Cashew nuts treatments reduced cytokines plasma levels, nitrotyrosine, and PARP expression as well as adhesion molecules expressions. Additionally, cashew nuts decreased the intestinal barrier dysfunction and mucosal damage, the translocation of toxins and bacteria, which leads to systemic inflammation and associated organs injuries in particular of liver and kidney. Our study demonstrates that cashew nuts administration exerts antioxidant and pharmacological protective effects in superior mesenteric artery occlusion–reperfusion shock.

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Section: Introductionmentioning

confidence: 99%

Consumption of Anacardium occidentale L. (Cashew Nuts) Inhibits Oxidative Stress through Modulation of the Nrf2/HO−1 and NF-kB Pathways

et al. 2020

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“…Catalase is an intracellular antioxidant enzyme effective in protecting cells from hydrogen peroxide [ 41 ]. Catalase is crucial in attenuating graft I/R injuries in the immediate phase after KTx [ 42 , 15 ].…”

Section: Resultsmentioning

confidence: 99%

Genetic susceptibility to delayed graft function following kidney transplantation: a systematic review of the literature

Huart

Krzesinski

Jouret

2018

Clinical Kidney Journal

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Delayed graft function (DGF) is defined as the need for dialysis within 7 days following kidney transplantation (KTx). DGF is associated with increased costs, higher risk for acute rejection and decreased long-term graft function. Renal ischaemia/reperfusion (I/R) injury plays a major role in DGF occurrence. Single nucleotide polymorphisms (SNPs) in certain genes may aggravate kidney susceptibility to I/R injury, thereby worsening post-transplant outcomes. The present article proposes an extensive review of the literature about the putative impact of donor or recipient SNPs on DGF occurrence in kidney transplant recipients (KTRs). Among 30 relevant PubMed reports, 16 articles identified an association between 18 SNPs and DGF. These polymorphisms concern 14 different well-known genes and one not-yet-identified gene located on chromosome 18. They have been categorized into five groups according to the role of the corresponding proteins in I/R cascade: (i) oxidative stress, (ii) telomere shortening, (iii) chemokines, (iv) T-cell homeostasis and (v) metabolism of anti-inflammatory molecules. The remaining 14 studies failed to demonstrate any association between the studied SNPs and the occurrence of DGF. A better understanding of the genetic susceptibility to renal I/R injury may help prevent DGF and improve clinical outcomes in KTRs.

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“…Con el fin de evitar la formación de ROS, o al menos paliar sus efectos a nivel celular, diversos estudios [2,6,7] sugieren que los antioxidantes son capaces de inhibir en gran medida el daño oxidativo causado por la I/R. Los antioxidantes son sustancias capaces de aceptar los electrones desapareados de los ROS, evitando así que estos oxiden otras moléculas en el tejido [8].…”

Section: Introductionunclassified

“…Utilizando el extractante adecuado, estas sustancias pueden ser extraídas de diversos organismos fotosintéticos, tanto de plantas vasculares [12,[17][18][19][20][21] como de algas [6,[22][23][24], y se ha demostrado que el extracto resultante puede tener una actividad antioxidante que puede ser utilizada para paliar el daño por I/R.…”

Section: Introductionunclassified

“…Por una parte, los fucoidanos del alga parda Fucus vesiculosus han mostrado su eficacia frente a la apoptosis y la autofagia de las células hepáticas de ratones cuando se ven sometidas a la lesión por I/R [22]. Del mismo modo, los extractos organoacuosos de Himanthalia elongata han mostrado un gran potencial en el tratamiento de la lesión intestinal por I/R en ratas [6]. Por otra parte, se ha visto que el bromofenol extraído de algas rojas posee una notable capacidad antioxidante frente a los radicales libres generados en la lesión por I/R en cardiomiocitos de embriones de rata [25].…”

Section: Introductionunclassified

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Determinación de la actividad tóxica de extractos optimizados de Palmaria y Porphyra para el tratamiento de la lesión por isquemia/reperfusión

Irisarri

Sanz

2020

Nereis

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La lesión por isquemia-reperfusión (I/R) puede provocar rechazos en los trasplantes de órganos debido al daño a nivel celular que producen los Radicales Libres de Oxígeno (ROS). Se ha comprobado que los antioxidantes naturales pueden reducir este daño. Los extractos de muchas algas poseen una actividad antioxidante notable, pero se necesita comprobar la toxicidad de estos antes de proponerlos como fármacos. En este estudio, se realizaron dos ensayos toxicológicos con queratinocitos humanos inmortalizados (HaCaT) y nauplios de Artemia salina para valorar la toxicidad de dos extractos con actividad antioxidante de Palmaria palmata y Porphyra sp. Se obtuvieron LC50 de 7,843% (v/v) de concentración de extracto en P. palmata en el ensayo con HaCaT y 3,2583% (v/v) en el ensayo con A. salina, mientras que con Porphyra sp. se obtuvo 10,7463% (v/v) en el ensayo con HaCaT y 6,5688% (v/v) en el ensayo con A. salina. Los Niveles Sin Efecto Adverso Observable (NOAEL) obtenidos para cada alga en cada ensayo mostraron significativamente una mayor toxicidad del extracto de P. palmata que del de Porphyra sp. (p < 0,05). Finalmente, se propuso un índice que tiene en cuenta la actividad antioxidante y la toxicidad de cada extracto para predecir su eficiencia in vivo, confirmando los resultados anteriores, y por ello se escogió el extracto de Porphyra sp. como el más idóneo para continuar con los ensayos preclínicos en el desarrollo de un fármaco para el tratamiento de la lesión por I/R.

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Antioxidant potential of Himanthalia elongata for protection against ischemia-reperfusion injury in the small bowel

Cited by 10 publications

References 35 publications

Consumption of Anacardium occidentale L. (Cashew Nuts) Inhibits Oxidative Stress through Modulation of the Nrf2/HO−1 and NF-kB Pathways

Consumption of Anacardium occidentale L. (Cashew Nuts) Inhibits Oxidative Stress through Modulation of the Nrf2/HO−1 and NF-kB Pathways

Genetic susceptibility to delayed graft function following kidney transplantation: a systematic review of the literature

Determinación de la actividad tóxica de extractos optimizados de Palmaria y Porphyra para el tratamiento de la lesión por isquemia/reperfusión

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