Antioxidant Potential of Caesalpenia Bonducella Seeds in the Management of Polycystic Ovary Syndrome (PCOS) Using Mifepristone Induced Rats Model

Predicting the potential impacts of climate change on the endangered Caesalpinia bonduc (L.) Roxb in Benin (West Africa)

“…, 2011 ). Recently, the studies on seed extraction showed that C. bonduc contains antioxidant properties that can be used to prevent the lipid peroxidation of the cell membrane and the management of polycystic ovary syndrome ( Suhani et al., 2019 ; Meera et al., 2020 ; Sumithra et al., 2021 ; Kandasamy and Balasundaram, 2021 ).…”

Effects of natural products on polycystic ovary syndrome: From traditional medicine to modern drug discovery

“…Administrating Caesalpenia bonducella (CB) dose-dependently increased enzymatic antioxidants and non-enzymatic antioxidants [ 56 ]. PCOS rats showed decreased superoxide dismutase (SOD), catalase (CAT), and, glutathione-S-transferase (GST) and increased glutathione peroxidase (GPx) and glucocorticoid receptor (GR), which were restored by the treatment of CB.…”

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“…The antioxidant activity on different rhizome extracts followed the order of CL-E ~ CL-C > CL-P. All the three extracts used in this study could inhibit the growth of all the bacterial strains, whereas CL-E and CL-P extracts were effective against selected fungal strains. Phytochemicals like polyphenols, flavonoids, and glycosides are well documented for contributing to the antioxidant activity of extracts 38,42,44,48 . It can be noted that CL-P extract did not contain flavanoids as well as glycosides, and this could be one of the reasons for its lower antioxidant activity as compared to CL-C and CL-E. Further, both CL-C and CL-E were comparable in terms of antioxidant activity, and this is attributed to the presence of phytochemicals like flavonoids and glycosides.…”

“…Notably, in this study, the chloroform extract had shown the highest antioxidant activity in terms of scavenging of DPPH radical, and petroleum ether extract was most effective for anti-bacterial and anti-fungal activities. However, both petroleum ether and chloroform do not belong to generally regarded as safe (GRAS) chemical, and therefore extracts prepared using these solvents may not be considered safe for human consumption or application 38 .…”

“…On the other hand, ethanol is considered as a food grade excipient and is widely used in the preparation of medicinal grade Ayurveda and/or homeopathy formulations 38 . Therefore, the present study was aimed to prepare ethanolic extract from rhizomes of Curcuma leucorrhiza Roxb and to compare its antioxidant, antibacterial, and antifungal properties with those prepared from petroleum ether and chloroform.…”