Antioxidant potential of mulberry and non-mulberry silk sericin and its implications in biomedicine

Recent Advances in Silk Sericin/Calcium Phosphate Biomaterials

“…In particular calcium-based nanoparticles have shown to have therapeutic benefits when used in cutaneous wound repair (Kawai et al, 2011). On the other hand, sericin has high antioxidant potential (Prasong, 2011;Kumar and Mandal, 2017), antibacterial activity (Ramesan et al, 2016), mitogenic effect on cells (Terada et al, 2005), potential to inhibit inflammation (Aramwit et al, 2012a), and ability to retain hydration (Padamwar et al, 2005). In the study of Aramwit et al, a sericin-based therapeutic cream formulation improved healing by promoting collagen production and rapid re-epithelialization in rat skin wounds (Aramwit et al, 2009(Aramwit et al, , 2013.…”

In vitro assessment of the bioactivities of sericin protein extracted from a bacterial silk-like biopolymer

“…The antioxidant potential of silk sericin is associated with its amino acid composition, especially the -OH groups of threonine and serine and the electron donating groups of the aromatic amino acids (histidine, phenylalanine, tyrosine and tryptophan), 28 in addition to the action of secondary metabolites, such as avonoids and polyphenols, which also contribute. 12 Furthermore, alteration in the pH of the protein during the extraction process, as when using a basic or acidic environment, along with the heating process, changes the amino acids' ionizations, thus producing sericin peptides with different lengths that contain many proportions of b-sheets, a-helices, turns and random coils. 39 The percentages of random coils and b-sheets respectively reect the amorphous nature and crystalline structure of sericin peptides.…”

“…10 The glycoprotein sericin possesses several biological properties, including antioxidation, immunomodulation, and inhibition of tyrosinase and elastase activities. 11,12 Recently, sericin was found to reduce reactive oxygen species (ROS), protect normal cells from UVB radiation oxidative damage and H 2 O 2 , inhibit cancer progression and be an anti-bacterial agent. 13,14 The exploitation of puried proteins or their extracts as antioxidant candidates has attracted particular attention.…”

Extraction and antioxidant activity of sericin, a protein from silk

“…J. Food Technol., Campinas, v. 23, e2019058, 2020 | https://doi.org/10.1590/1981-6723.05819 7/14 2016; Napavichayanun et al, 2017;Deori et al, 2016;Sangwong et al, 2016;Kumar & Mandal (2017); Fan et al, 2010;Kaewkon et al, 2012;Zhaorigetu et al, 2001;Dash et al, 2008), and inhibits tyrosinase activity (Aramwit et al, 2010a;Kato et al, 1998;Thongsook & Tiyaboonchai, 2011;Puangphet et al, 2015;Wu et al, 2008;Manosroi et al, 2010). Table 3 provides an overview of studies supporting the sericin's antioxidant activity.…”