Antioxidant potential study of some synthesized N-heterocycles

Hossain, Mohammad Mamun; Shaha, Sukanta Kumar; Aziz, Foysal

doi:10.3329/bmrcb.v35i2.2564

Cited by 30 publications

(25 citation statements)

References 14 publications

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“…After 6 min, 4.3% of sodium hydroxide solution was added, followed by addition of water, shaken, and left to stand for 15 min before determination. The sample solution without coloration was used as reference solution and the colour was read at 510 nm wavelength [21].…”

Section: Determination Of Total Flavonoid Content (Tfc)mentioning

confidence: 99%

Pharmacological Effects of Ethanol Extract of Artemisia Herba Alba in Streptozotocin-induced Type 1 Diabetes Mellitus in Rats

Abdallah¹,

Abdel-Rahman²

2015

Biochem Pharmacol (Los Angel)

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Background: Diabetes mellitus has been treated orally with herbal remedies based on folk medicine since ancient times. The current study investigates the protective effect of Artemisia herba alba (Ah) against experimentally-induced type 1 diabetes mellitus and its complications. Methods: Diabetes was induced in adult male Wister rats by administration of (Streptozotocin; STZ) at a dose of 52.5 mg/kg, i.p. Animals with diabetes were treated with either Ah ethanolic extract or gliclazide (10mg/kg, p.o.) for 14 days. Biochemical analysis was done such as glucose, insulin, homocysteine, lipid profile (cholesterol, triglyceride), liver function tests (T.bilirubin, AST and ALT), kidney function tests (BUN, sr. creatinine) and oxidative stress biomarkers. In addition, pancreas, liver, kidney, heart and aorta tissues were dissected out for pathological examination. Immuno histochemical study was done on pancreatic tissues for determination of insulin and glucagon immune reactivities. Liver tissues were also separated for genetic analysis. Results: Oral administration of Ah ethanolic extract at a concentration of 400, 200and 100 mg/kg daily for 14 days results in decreased fasting blood glucose and homocysteine levels as well as enhancement of plasma insulin level as compared with STZ-treated rats. The extract improved lipid profile, liver and kidney function tests. It also increased hepatic and renal contents of GSH, diminished lipid peroxidation, and inhibited pathological alterations induced in the different organs. Treatment with Ah extract increased insulin expression while decreased glucagon immunoreactivity and DNA band polymorphism. Conclusion: Thus, our results show that Ah possesses a promising antihyperglycemic effect that is comparable with gliclazide.

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Section: Determination Of Total Flavonoid Content (Tfc)mentioning

confidence: 99%

Pharmacological Effects of Ethanol Extract of Artemisia Herba Alba in Streptozotocin-induced Type 1 Diabetes Mellitus in Rats

Abdallah¹,

Abdel-Rahman²

2015

Biochem Pharmacol (Los Angel)

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“…One of these is to the synthesis of molecules having N and O heterocyclic moieties is determine their antioxidant efficacy. Nitrogen and oxygen-containing heterocyclic organic compounds show interesting chemical property as well as biological activity [18]. Furthermore, each of the compounds contains a high percentage of nitrogen or oxygen gave enhancement to the reactivity.…”

Section: Antioxidant Reactivitymentioning

confidence: 99%

Antioxidant Activity of Some Newly Prepared Symmetrically Azo Dyes Derived From Sulfa Drugs

Muhammad‐Ali

Salman

Jasim

2019

Asian J Pharm Clin Res

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Objective: Sulfa drugs (sulfonamides) were the first type of drugs largely medically used for preventive and chemotherapeutic agents against various types of diseases. To the date, much research has been directed toward the synthesis sulfa drug derivatives such as azo‑sulfa drug compounds. The aim of the present study is to synthesize of azo‑sulfa compounds as antioxidant agents. Methods: First, three of sulfa drugs react with 4‑methoxy‑1,2‑Naphthoquinone in aqueous medium by stirring at room temperature to give symmetrically azo‑sulfa compounds. The colored compounds which formed were examined their structures by infrared and proton nuclear magnetic resonance spectral techniques. Results: Three symmetrically azo‑sulfa compounds were tested as antioxidant agents compared with ascorbic acid (AA) using 2,2‑diphenyl‑1‑picrylhydrazyl method. The results indicated that these compounds had good activities (57.79–73.69%) at 30 μg/ml, which had less activity than AA (81.34%) at the same concentration. These results referred the IC50 which had values (15.23–21.35 μg/ml), whereas AA had 7.59 μg/ml. Conclusion: Attachment of heterocyclic rings containing nitrogen and oxygen (isoxazole) on the azo‑sulfa compounds can enhance the antioxidant activity as compared with the heterocyclic rings containing nitrogen only (pyrimidine) and without heterocyclic rings, which enhanced the lipophilicity which may increase the bioavailability and efficacy of the drug.

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“…The presence of 2-quinolone with EWG in a pyrazoline ring showed increased antioxidant activity . Nitrogen-containing heterocyclic compounds with the electron-withdrawing nature of halogen groups showed greater antioxidant property (Hossain et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Synthesis of some novel 3- (4-ethoxyphenyl) -5- (4-substituted) -4,5-dihydro-1H-pyrazole derivatives as potent antioxidant agents

Lakshminarayanan¹,

Kannappan

Subburaju³

et al. 2020

ijrps

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Pyrazolines are the most useful heterocyclic moiety in Pharmaceutical and Chemical ields and as the most potential molecules for the design of new chemical entities. Nitrogen-containing heterocyclic compounds, pyrazolines and their derivatives showed a variety of pharmacological activities, including antioxidant properties. In the present study, eleven novel ethoxylated pyrazoline derivatives were synthesized by condensing chalcones with electron releasing ethoxy group at one end and different electron-donating, electronwithdrawing groups in another end with hydrazine hydrate and alcohol. The compounds synthesized were structural elucidated by their spectroscopic studies. All the compounds synthesized were evaluated for their in vitro antioxidant potential by 2,2'-diphenyl-1-picrylhydrazyl (DPPH) and hydrogen peroxide free radical scavenging assay methods. Some of these molecules possess moderate to good antioxidant activity when compared to standard ascorbic acid. The compound with methoxy group (EH2) exhibits potent antioxidant activity with IC 50 value of 9.02 and 9.44µg/ml in DPPH and hydrogen peroxide assay methods respectively and the compound with hydroxy group (EH9) also showed potent antioxidant activity with IC 50 value of 12.41 and 14.56µg/ml in DPPH and hydrogen peroxide free radical scavenging assay methods respectively when compared to standard. The compounds containing electron-donating substituents were found to be good antioxidants when compared to standard ascorbic acid.

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Antioxidant potential study of some synthesized N-heterocycles

Cited by 30 publications

References 14 publications

Pharmacological Effects of Ethanol Extract of Artemisia Herba Alba in Streptozotocin-induced Type 1 Diabetes Mellitus in Rats

Pharmacological Effects of Ethanol Extract of Artemisia Herba Alba in Streptozotocin-induced Type 1 Diabetes Mellitus in Rats

Antioxidant Activity of Some Newly Prepared Symmetrically Azo Dyes Derived From Sulfa Drugs

Synthesis of some novel 3- (4-ethoxyphenyl) -5- (4-substituted) -4,5-dihydro-1H-pyrazole derivatives as potent antioxidant agents

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