Antioxidant Potential, Total Phenolic and Flavonoid Contents from the Stem Bark of Guazuma ulmifolia Lam.

Feltrin, Andriéli Cassel; Boligon, Alexandra Augusti; Janovik, Vanessa; Athayde, Margareth Linde

doi:10.3923/ajbs.2012.268.272

Cited by 10 publications

(8 citation statements)

References 13 publications

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“…The quantity of phenolic compounds can directly affect the biological potential of natural products [ 43 ], including the antioxidant activity of medicinal plants [ 43 – 45 ]. In this study, a high phenolic content was found in both extracts, and GUEsb showed a higher phenolic content than GUEl and one similar to that found by Feltrin et al [ 27 ] in 70% hydroethanolic extract from G. ulmifolia stem bark. GUEsb showed a higher DPPH radical scavenging activity than GUEl.…”

Section: Discussionsupporting

confidence: 89%

“…Pharmacological studies have confirmed the antidiabetic potential of stem bark and leaves [ 22 , 23 ], the hypotensive and vasorelaxant effects of G. ulmifolia stem bark [ 24 ], and the antihypercholesterolemic [ 25 ] and gastroprotective [ 26 ] activity of G. ulmifolia leaves. Phytochemical studies of G. ulmifolia leaves, fruits [ 21 ], and stem bark [ 27 ] identified phenolic compounds that are reported in the literature for their antioxidant activity [ 28 – 30 ] and that may contribute to the pharmacological activities described above.…”

Section: Introductionmentioning

confidence: 99%

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Guazuma ulmifolia Lam. Decreases Oxidative Stress in Blood Cells and Prevents Doxorubicin‐Induced Cardiotoxicity

Santos

Alfredo

Antunes

et al. 2018

Oxidative Medicine and Cellular Longevity

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Doxorubicin (DOX) is an efficient chemotherapeutic agent, but its clinical application is limited by its cardiotoxicity associated with increased oxidative stress. Thus, the combination of DOX and antioxidants has been encouraged. In this study, we evaluated (I) the chemical composition and antioxidant capacity of aqueous extracts from Guazuma ulmifolia stem bark (GUEsb) and leaves (GUEl) in 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging, 2,2′-azobis(2-amidinopropane) dihydrochloride- (AAPH-) or DOX-induced lipid peroxidation inhibition in human blood cells, and intracellular reactive oxygen species (ROS) quantification using the fluorescent probe dichloro-dihydro-fluorescein diacetate (DCFH-DA) in K562 erythroleukemia cells incubated with GUEsb and stimulated with hydrogen peroxide; (II) the viability of K562 cells and human leukocytes treated with GUEsb in the absence or presence of DOX using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay; (III) the acute toxicity of GUEsb; and (IV) the cardioprotective effect of GUEsb in C57Bl/6 mice treated with DOX. The chemical composition indicated the presence of flavan-3-ol derivatives and condensed tannins in GUEsb and glycosylated flavonoids in GUEl. GUEsb and GUEl showed free-radical scavenging antioxidant activity, antihemolytic activity, and AAPH- as well as DOX-induced malondialdehyde content reduction in human erythrocytes. Based on its higher antioxidant potential, GUEsb was selected and subsequently showed intracellular ROS reduction without impairing the chemotherapeutic activity of DOX in K562 cells or inducing leukocyte cell death, but protected them against DOX-induced cell death. Yet, GUEsb did not show in vivo acute toxicity, and it prevented MDA generation in the cardiac tissue of DOX-treated mice, thus demonstrating its cardioprotective effect. Taken together, the results show that GUEsb and GUEl are natural alternatives to treat diseases associated with oxidative stress and that, in particular, GUEsb may play an adjuvant role in DOX chemotherapy.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Guazuma ulmifolia Lam. Decreases Oxidative Stress in Blood Cells and Prevents Doxorubicin‐Induced Cardiotoxicity

Santos

Alfredo

Antunes

et al. 2018

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

show abstract

“…In India, this tree was introduced more than 100 years ago and, today, it thrives along roadsides and in wasteland. Based on many previous studies, G. ulmifolia had been used as antiobesity (Iswantini et al, 2011), antioxidant (Feltrin et al,2012), photocatalyst, antimicrobial and anticancer agents (Karthika et al, 2017), and hepatoprotective drugs (Sharma et al, 2013). Some of which are associated with oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

The ethanol extract of the bastard cedar (Guazuma ulmifolia L.) as antioxidants

Prahastuti¹,

Hidayat²,

Hasiana³

et al. 2020

Pharmaciana

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Guazuma ulmifolia, or commonly known as the bastard cedar, has many pharmaceutical activities. Therefore, it is claimed as a source of various plant-based medicines. This research was purposed to identify the antioxidant activities of the ethanolic extract of G. ulmifolia (EEGU) by phytochemical screening assay, total flavonoid and total phenolic testing, and comparative analysis between the antioxidant activities of EEGU and epicatechin. The qualitative phytochemical screening assay of EEGU detected the availability of phenols, flavonoids, alkaloids, tannins, and terpenoids, but not saponins and triterpenoids. Meanwhile, the total phenolic content was 32.24 µg GAE/mg extract, and the total flavonoid content was 6.48 µg QE/mg extract. The role of antioxidants examined by FRAP, DPPH, H 2 O 2 , and ABTS assays. These assays are proved that the IC 50 values of EEGU are higher than epicatechin. For DPPH scavenging, H 2 O 2 scavenging, and ABTS reduction activities, EEGU resulted IC 50 45.70 μg/mL, 162.93 μg/mL, and 35.96 μg/mL, while epicatechin only yielded IC 50 0.56 μg/mL, 57.91 μg/mL, and 16.74 μg/mL respectively. Otherwise, the highest reduction in FRAP activities were shown at 50 μg/mL concentration of epicatechin and EEGU were 236.33 and 202.71 µM Fe (II)/µg respectively. Based on these results, EEGU is concluded as an active natural product because it exhibited antioxidant activities.

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“…known as "chico-magro" or "mutamba" occurs in all of Latin. It is popularly used for the treatment of dandruff, hypercholesterolemic and to reduce [9]. Antimicrobial properties have been described previously from G. ulmifolia leaves and stem bark [10] species also showed antiulcer activity that is related to the presence of several anthocyanidins isolated from stem bark of G. ulmifolia ethyl acetate fraction [11].…”

Section: Introductionmentioning

confidence: 99%

Essential Oil Composition, Antioxidant and Antimicrobial Activities of Guazuma Ulmifolia from Brazil

2012

Med Aromat Plants

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Antioxidant Potential, Total Phenolic and Flavonoid Contents from the Stem Bark of Guazuma ulmifolia Lam.

Cited by 10 publications

References 13 publications

Guazuma ulmifolia Lam. Decreases Oxidative Stress in Blood Cells and Prevents Doxorubicin‐Induced Cardiotoxicity

Guazuma ulmifolia Lam. Decreases Oxidative Stress in Blood Cells and Prevents Doxorubicin‐Induced Cardiotoxicity

The ethanol extract of the bastard cedar (Guazuma ulmifolia L.) as antioxidants

Essential Oil Composition, Antioxidant and Antimicrobial Activities of Guazuma Ulmifolia from Brazil

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