Antioxidant Properties and Beneficial Cardiovascular Effects of a Natural Extract of Pomegranate in Healthy Volunteers: A Randomized Preliminary Single-Blind Controlled Study

Al-Dujaili, Emad A S; Casey, Ciara S.; Stockton, Angela

doi:10.3390/antiox11112124

Cited by 12 publications

(17 citation statements)

References 63 publications

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“…Moreover, the intervention duration varied from 2 weeks (Kojadinovic et al., 2021; Manthou et al., 2017) to 24 (Wu et al., 2015) weeks, and the sample size differed from 10 (Manthou et al., 2017) to 77 (Park et al., 2014) participants. The design of 26 trials was parallel RCT (Abedini et al., 2021; Akbarpour et al., 2021; Al‐Dujaili et al., 2022; Babaeian et al., 2013; Esmaeilinezhad et al., 2019; Faghihimani et al., 2016; González‐Ortiz et al., 2011; Goodarzi et al., 2021; Grabež et al., 2020; Hosseini et al., 2016; Irani et al., 2020; Kojadinovic et al., 2017, 2021; Lynn et al., 2012; Manthou et al., 2017; Mirmiran et al., 2010; Nemati et al., 2022; Park et al., 2014; Rouzbehan et al., 2021; Sohrab et al., 2014, 2019; Stockton et al., 2017; Sumner et al., 2005; Wu et al., 2015; Yarmohammadi & Mahjoub, 2017; Zarezadeh et al., 2019), and the two (Barati Boldaji et al., 2020; Tsang et al., 2012) were performed in a crossover design. Included studies possessed different subjects including patients with coronary heart disease (Sumner et al., 2005), hyperlipidemic individuals (Mirmiran et al., 2010), Obese participants (González‐Ortiz et al., 2011), individuals who were at high CVD risk (Tsang et al., 2012), healthy young and middle‐aged men and women (Lynn et al., 2012), type 2 diabetic individuals (Babaeian et al., 2013; Faghihimani et al., 2016; Grabež et al., 2020; Nemati et al., 2022; Sohrab et al., 2014, 2019; Yarmohammadi & Mahjoub, 2017), overweight participants (Park et al., 2014), hemodialysis patients (Barati Boldaji et al., 2020; Wu et al., 2015), overweight and obese individuals (Hosseini et al., …”

Section: Resultsmentioning

confidence: 99%

“…Moreover, the intervention duration varied from 2 weeks (Kojadinovic et al, 2021;Manthou et al, 2017) to 24 (Wu et al, 2015) weeks, and the sample size differed from 10 ( Manthou et al, 2017) to 77 (Park et al, 2014) participants. The design of 26 trials was parallel RCT (Abedini et al, 2021;Akbarpour et al, 2021;Al-Dujaili et al, 2022;Babaeian et al, 2013;Esmaeilinezhad et al, 2019;Faghihimani et al, 2016;González-Ortiz et al, 2011;Goodarzi et al, 2021;Grabež et al, 2020;Hosseini et al, 2016;Irani et al, 2020;Kojadinovic et al, 2017Kojadinovic et al, , 2021Lynn et al, 2012;Manthou et al, 2017;Mirmiran et al, 2010;Nemati et al, 2022;Park et al, 2014;Rouzbehan et al, 2021;Sohrab et al, 2014Sohrab et al, , 2019Stockton et al, 2017;Sumner et al, 2005;Wu et (Tsang et al, 2012), healthy young and middle-aged men and women (Lynn et al, 2012), type 2 diabetic individuals (Babaeian et al, 2013;Faghihimani et al, 2016;Grabež et al, 2020;Nemati et al, 2022;Sohrab et al, 2014Sohrab et al, , 2019Yarmohammadi & Mahjoub, 2017), overweight participants (Park et al, 2014), hemodialysis patients …”

Section: Study Characteristicmentioning

confidence: 99%

“…The design of 26 trials was parallel RCT (Abedini et al, 2021;Akbarpour et al, 2021;Al-Dujaili et al, 2022;Babaeian et al, 2013;Esmaeilinezhad et al, 2019;Faghihimani et al, 2016;González-Ortiz et al, 2011;Goodarzi et al, 2021;Grabež et al, 2020;Hosseini et al, 2016;Irani et al, 2020;Kojadinovic et al, 2017Kojadinovic et al, , 2021Lynn et al, 2012;Manthou et al, 2017;Mirmiran et al, 2010;Nemati et al, 2022;Park et al, 2014;Rouzbehan et al, 2021;Sohrab et al, 2014Sohrab et al, , 2019Stockton et al, 2017;Sumner et al, 2005;Wu et (Tsang et al, 2012), healthy young and middle-aged men and women (Lynn et al, 2012), type 2 diabetic individuals (Babaeian et al, 2013;Faghihimani et al, 2016;Grabež et al, 2020;Nemati et al, 2022;Sohrab et al, 2014Sohrab et al, , 2019Yarmohammadi & Mahjoub, 2017), overweight participants (Park et al, 2014), hemodialysis patients (Barati Boldaji et al, 2020;Wu et al, 2015), overweight and obese individuals (Hosseini et al, 2016;Zarezadeh et al, 2019), healthy participants (Al-Dujaili et al, 2022;Manthou et al, 2017;…”

Section: Study Characteristicmentioning

confidence: 99%

“…Mirmiran et al, 2010;Nemati et al, 2022;Rouzbehan et al, 2021;Sohrab et al, 2014Sohrab et al, , 2019Yarmohammadi & Mahjoub, 2017;Zarezadeh et al, 2019), Mexico(González-Ortiz et al, 2011), South Korea(Park et al, 2014), Scotland(Stockton et al, 2017), Serbia(Kojadinovic et al, 2017(Kojadinovic et al, , 2021, Greece(Manthou et al, 2017), and Bosnia and Herzegovina(Grabež et al, 2020). Seven studies were performed on females(Abedini et al, 2021;Akbarpour et al, 2021;Esmaeilinezhad et al, 2019;Kojadinovic et al, 2017;Park et al, 2014;Rouzbehan et al, 2021;Yarmohammadi & Mahjoub, 2017), two studies on males(Irani et al, 2020;Nemati et al, 2022), and the others were carried out on both genders(Al-Dujaili et al, 2022;Babaeian et al, 2013;Barati Boldaji et al, 2020;Faghihimani et al, 2016;González-Ortiz et al, 2011;Goodarzi et al, 2021;Grabež et al, 2020;Hosseini et al, 2016;Kojadinovic et al, 2021;Lynn et al, 2012;Manthou et al, 2017;Mirmiran et al, 2010;Sohrab et al, 2014Sohrab et al, , 2019Stockton et al, 2017;Sumner et al, 2005;Tsang et al, 2012;…”

mentioning

confidence: 99%

“…Seven studies were performed on females(Abedini et al, 2021;Akbarpour et al, 2021;Esmaeilinezhad et al, 2019;Kojadinovic et al, 2017;Park et al, 2014;Rouzbehan et al, 2021;Yarmohammadi & Mahjoub, 2017), two studies on males(Irani et al, 2020;Nemati et al, 2022), and the others were carried out on both genders(Al-Dujaili et al, 2022;Babaeian et al, 2013;Barati Boldaji et al, 2020;Faghihimani et al, 2016;González-Ortiz et al, 2011;Goodarzi et al, 2021;Grabež et al, 2020;Hosseini et al, 2016;Kojadinovic et al, 2021;Lynn et al, 2012;Manthou et al, 2017;Mirmiran et al, 2010;Sohrab et al, 2014Sohrab et al, , 2019Stockton et al, 2017;Sumner et al, 2005;Tsang et al, 2012;Wu et al, 2015;Zarezadeh et al, 2019). The characteristics of the included studies are demonstrated in Table1.3.3 | Quality assessmentThe general risk of bias was evaluated and indicated in 23 studies with a good risk of bias(Akbarpour et al, 2021;Al-Dujaili et al, 2022;Barati Boldaji et al, 2020;Esmaeilinezhad et al, 2019;Faghihimani et al, 2016;González-Ortiz et al, 2011;Goodarzi et al, 2021;Grabež et al, 2020;Hosseini et al, 2016;Irani et al, 2020;Kojadinovic et al, 2021;…”

mentioning

confidence: 99%

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The effects of pomegranate consumption on obesity indices in adults: A systematic review and meta‐analysis

Bahari,

Pourreza,

Goudarzi

et al. 2023

Food Science & Nutrition

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Evidence supports the potential application of polyphenols as agents against obesity. Pomegranate is one of the fruits that possess a high content of polyphenols. This systematic review and meta‐analysis of randomized controlled trials (RCTs) sought to evaluate the effects of pomegranate consumption on obesity indices, including body mass index (BMI), body weight, waist circumference (WC), fat mass (FM), body fat percentage (BFP), and fat‐free mass (FFM) in adults. Relevant RCTs were obtained by searching databases, including PubMed, SCOPUS, and Web of Science, up to May 2023. Heterogeneity tests of the included trials were performed using the I2 statistic. Random effects models were assessed based on the heterogeneity tests, and pooled data were determined as the weighted mean difference with a 95% confidence interval. Pooled analysis of 28 trials revealed that pomegranate consumption led to a significant reduction in body weight (WMD: −1.97, 95% CI: −2.91, −1.03, p < .05), and a significant decrease in BMI (WMD: −0.48, 95% CI: −0.76, −0.20, p < .05) in comparison with the control group. However, there were no significant effects on WC, FM, FFM, and BFP in comparison with the control group. Pomegranate consumption may yield a beneficial effect on body weight and BMI in adults. However, there were no significant effects on WC, FM, FFM, and BFP, by pomegranate consumption. Also, pomegranate consumption can reduce body weight, BMI, WC, and BFP in obese adults. Long‐term trials with different doses of pomegranate are needed.

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Section: Resultsmentioning

confidence: 99%

Section: Study Characteristicmentioning

confidence: 99%

Section: Study Characteristicmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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The effects of pomegranate consumption on obesity indices in adults: A systematic review and meta‐analysis

Bahari,

Pourreza,

Goudarzi

et al. 2023

Food Science & Nutrition

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The effects of pomegranate consumption on blood pressure in adults: A systematic review and meta‐analysis

Bahari,

Omidian,

Goudarzi

et al. 2024

Phytotherapy Research

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Considering the main component of cardiovascular disease and due to the high prevalence of hypertension, controlling blood pressure is required in individuals with various health conditions. Randomized clinical trials (RCTs) which studied the effects of pomegranate consumption on blood pressure have shown inconsistent findings. As a result, we intended to assess the effects of pomegranate consumption on systolic (SBP) and diastolic (DBP) blood pressure in adults. Systematic literature searches up to January 2024 were carried out using electronic databases, including PubMed, Web of Science, and Scopus, to identify eligible RCTs assessing the effects of pomegranate on blood pressure as an outcome. All the individuals who took part in our research were adults who consumed pomegranate in different forms as part of the study intervention. Heterogeneity tests of the selected trials were performed using the I2 statistic. Random effects models were assessed based on the heterogeneity tests, and pooled data were determined as the weighted mean difference (WMD) with a 95% confidence interval (CI). Of 2315 records, 22 eligible RCTs were included in the current study. Our meta‐analysis of the pooled findings showed that pomegranate consumption significantly reduced SBP (WMD: −7.87 mmHg; 95% CI: −10.34 to −5.39; p < 0.001) and DBP (WMD: −3.23 mmHg; 95% CI: −5.37 to −1.09; p = 0.003). Individuals with baseline SBP > 130 mmHg had a significantly greater reduction in SBP compared to individuals with baseline SBP < 130 mmHg. Also, there was a high level of heterogeneity among studies (SBP: I2 = 90.0% and DBP: I2 = 91.8%). Overall, the results demonstrated that pomegranate consumption lowered SBP and DBP in adults. Although our results suggest that pomegranate juice may be effective in reducing blood pressure in the pooled data, further high‐quality studies are needed to demonstrate the clinical efficacy of pomegranate consumption.

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Plant Foods with Cardioprotective Properties

Sobajic,

Todorovic

2024

Cardioprotective Plants

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Antioxidant Properties and Beneficial Cardiovascular Effects of a Natural Extract of Pomegranate in Healthy Volunteers: A Randomized Preliminary Single-Blind Controlled Study

Cited by 12 publications

References 63 publications

The effects of pomegranate consumption on obesity indices in adults: A systematic review and meta‐analysis

The effects of pomegranate consumption on obesity indices in adults: A systematic review and meta‐analysis

The effects of pomegranate consumption on blood pressure in adults: A systematic review and meta‐analysis

Plant Foods with Cardioprotective Properties

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