Antioxidant Properties of a Pharmaceutical Substance Hypocard, a Potential Drug for Ischemic Disease

Neganova, Margarita E.; Клочков, С. Г.; Shevtsova, E. F.; Bogatyrenko, T. N.; Мищенко, Д. В.

doi:10.1007/s10517-018-4286-4

Cited by 7 publications

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“…Several classes of approved drugs have been studied through the years for their antioxidant properties [ 1 , 5 , 6 ]. Proton pump inhibitors [ 7 ], antidiabetics [ 8 ], drugs acting on the cardiovascular system [ 9 ], antiepileptics [ 10 ], and anti-inflammatory agents [ 11 ] represent some of the investigated classes, which are also paired by antioxidant natural and semi-synthetic compounds with biological activity [ 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 ]. Furthermore, besides therapeutic agents, it must be stressed that bioactive components from diet have been recognized among the risk factors or, on the other hand, protective agents possibly influencing oxidative stress and pathogenesis of related diseases [ 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant Potential of Psychotropic Drugs: From Clinical Evidence to In Vitro and In Vivo Assessment and toward a New Challenge for in Silico Molecular Design

et al. 2020

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Due to high oxygen consumption, the brain is particularly vulnerable to oxidative stress, which is considered an important element in the etiopathogenesis of several mental disorders, including schizophrenia, depression and dependencies. Despite the fact that it is not established yet whether oxidative stress is a cause or a consequence of clinic manifestations, the intake of antioxidant supplements in combination with the psychotropic therapy constitutes a valuable solution in patients’ treatment. Anyway, some drugs possess antioxidant capacity themselves and this aspect is discussed in this review, focusing on antipsychotics and antidepressants. In the context of a collection of clinical observations, in vitro and in vivo results are critically reported, often highlighting controversial aspects. Finally, a new challenge is discussed, i.e., the possibility of assessing in silico the antioxidant potential of these drugs, exploiting computational chemistry methodologies and machine learning. Despite the physiological environment being incredibly complex and the detection of meaningful oxidative stress biomarkers being all but an easy task, a rigorous and systematic analysis of the structural and reactivity properties of antioxidant drugs seems to be a promising route to better interpret therapeutic outcomes and provide elements for the rational design of novel drugs.

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Section: Introductionmentioning

confidence: 99%

“…Scheme 3. N-acetyl cysteine (8), rutin(9), melatonin (10), hydroxytyrosol(11), caffeic acid phenethyl ester(12), resveratrol(13), quercetin(14), lycopene(15), apocynin(16) and ebselen(17).…”

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confidence: 99%